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IID00566
 UniprotQ14451
ProteinGrowth factor receptor-bound protein 7
GeneGRB7
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
532
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 100-186 Monomer :
 Evidence NMR 1wgr A Reference
       Region 1wgr A 100-186 order
       Region 1wgr A 134-139 high_rmsd
Seq 415-532 Monomer :
 Evidence X-RAY 5eel F Reference
       Region 5eel F 415-426 disorder
       Region 5eel F 427-530 order
       Region 5eel F 531-532 disorder
 Evidence X-RAY 5eel E Reference
       Region 5eel E 415-428 disorder
       Region 5eel E 429-530 order
       Region 5eel E 531-532 disorder
 Evidence X-RAY 5eel D Reference
       Region 5eel D 415-427 disorder
       Region 5eel D 428-529 order
       Region 5eel D 530-532 disorder
 Evidence X-RAY 5eel C Reference
       Region 5eel C 415-426 disorder
       Region 5eel C 427-532 order
 Evidence X-RAY 5eel B Reference
       Region 5eel B 415-420 disorder
       Region 5eel B 421-529 order
       Region 5eel B 530-532 disorder
 Evidence X-RAY 5eel A Reference
       Region 5eel A 415-425 disorder
       Region 5eel A 426-529 order
       Region 5eel A 530-532 disorder
Seq 415-532 Hetero dimer : IID00293Complex
 Evidence NMR 1mw4 A Reference
       Region 1mw4 A 415-532 order
       Region 1mw4 A 415-418 high_rmsd
 Evidence NMR 2l4k A Reference
       Region 2l4k A 415-532 order
       Region 2l4k A 415-429 high_rmsd
       Region 2l4k A 532-532 high_rmsd
Seq 415-532 Hetero trimer :
 Evidence X-RAY 5d0j C Reference
       Region 5d0j C 415-428 disorder
       Region 5d0j C 429-530 order
       Region 5d0j C 531-532 disorder
 Evidence X-RAY 5d0j D Reference
       Region 5d0j D 415-423 disorder
       Region 5d0j D 424-488 order
       Region 5d0j D 489-489 disorder
       Region 5d0j D 490-528 order
       Region 5d0j D 529-532 disorder
Seq 415-532 Hetero trimer :
 Evidence X-RAY 5d0j A Reference
       Region 5d0j A 415-425 disorder
       Region 5d0j A 426-531 order
       Region 5d0j A 532-532 disorder
 Evidence X-RAY 5d0j B Reference
       Region 5d0j B 415-421 disorder
       Region 5d0j B 422-486 order
       Region 5d0j B 487-487 disorder
       Region 5d0j B 488-529 order
       Region 5d0j B 530-532 disorder
Seq 415-532 Homo dimer :
 Evidence X-RAY 4wwq B Reference
       Region 4wwq B 415-532 order
 Evidence X-RAY 4wwq A Reference
       Region 4wwq A 415-420 disorder
       Region 4wwq A 421-532 order
 Evidence X-RAY 5u06 D Reference
       Region 5u06 D 415-424 disorder
       Region 5u06 D 425-487 order
       Region 5u06 D 488-489 disorder
       Region 5u06 D 490-529 order
       Region 5u06 D 530-532 disorder
 Evidence X-RAY 5u06 C Reference
       Region 5u06 C 415-422 disorder
       Region 5u06 C 423-530 order
       Region 5u06 C 531-532 disorder
 Evidence X-RAY 5u06 B Reference
       Region 5u06 B 415-426 disorder
       Region 5u06 B 427-528 order
       Region 5u06 B 529-532 disorder
 Evidence X-RAY 5u06 A Reference
       Region 5u06 A 415-425 disorder
       Region 5u06 A 426-532 order
 Evidence X-RAY 5tyi D Reference
       Region 5tyi D 415-424 disorder
       Region 5tyi D 425-487 order
       Region 5tyi D 488-488 disorder
       Region 5tyi D 489-527 order
       Region 5tyi D 528-532 disorder
 Evidence X-RAY 5tyi C Reference
       Region 5tyi C 415-425 disorder
       Region 5tyi C 426-485 order
       Region 5tyi C 486-486 disorder
       Region 5tyi C 487-530 order
       Region 5tyi C 531-532 disorder
 Evidence X-RAY 5tyi B Reference
       Region 5tyi B 415-422 disorder
       Region 5tyi B 423-487 order
       Region 5tyi B 488-489 disorder
       Region 5tyi B 490-529 order
       Region 5tyi B 530-532 disorder
 Evidence X-RAY 5tyi A Reference
       Region 5tyi A 415-424 disorder
       Region 5tyi A 425-486 order
       Region 5tyi A 487-487 disorder
       Region 5tyi A 488-529 order
       Region 5tyi A 530-532 disorder
 Evidence X-RAY 2qms D Reference
       Region 2qms D 415-419 disorder
       Region 2qms D 420-532 order
 Evidence X-RAY 2qms C Reference
       Region 2qms C 415-419 disorder
       Region 2qms C 420-532 order
 Evidence X-RAY 2qms B Reference
       Region 2qms B 415-419 disorder
       Region 2qms B 420-532 order
 Evidence X-RAY 2qms A Reference
       Region 2qms A 415-419 disorder
       Region 2qms A 420-532 order
Seq 415-532 Hetero tetramer :
 Evidence X-RAY 5u1q C Reference
       Region 5u1q C 415-422 disorder
       Region 5u1q C 423-487 order
       Region 5u1q C 488-488 disorder
       Region 5u1q C 489-528 order
       Region 5u1q C 529-532 disorder
 Evidence X-RAY 5u1q D Reference
       Region 5u1q D 415-428 disorder
       Region 5u1q D 429-529 order
       Region 5u1q D 530-532 disorder
Seq 415-532 Hetero dimer :
 Evidence X-RAY 5eeq B Reference
       Region 5eeq B 415-423 disorder
       Region 5eeq B 424-527 order
       Region 5eeq B 528-532 disorder
Seq 415-532 Hetero tetramer :
 Evidence X-RAY 5u1q A Reference
       Region 5u1q A 415-428 disorder
       Region 5u1q A 429-528 order
       Region 5u1q A 529-532 disorder
 Evidence X-RAY 5u1q B Reference
       Region 5u1q B 415-421 disorder
       Region 5u1q B 422-528 order
       Region 5u1q B 529-532 disorder
Seq 415-532 Hetero dimer :
 Evidence X-RAY 5eeq A Reference
       Region 5eeq A 415-425 disorder
       Region 5eeq A 426-528 order
       Region 5eeq A 529-532 disorder
Seq 416-532 Hetero trimer :
 Evidence X-RAY 3pqz A Reference
       Region 3pqz A 416-423 disorder
       Region 3pqz A 424-462 order
       Region 3pqz A 463-463 disorder
       Region 3pqz A 464-528 order
       Region 3pqz A 529-532 disorder
 Evidence X-RAY 3pqz D Reference
       Region 3pqz D 416-428 disorder
       Region 3pqz D 429-487 order
       Region 3pqz D 488-489 disorder
       Region 3pqz D 490-527 order
       Region 3pqz D 528-532 disorder
Seq 416-532 Hetero trimer :
 Evidence X-RAY 3pqz B Reference
       Region 3pqz B 416-422 disorder
       Region 3pqz B 423-463 order
       Region 3pqz B 464-464 disorder
       Region 3pqz B 465-487 order
       Region 3pqz B 488-488 disorder
       Region 3pqz B 489-529 order
       Region 3pqz B 530-532 disorder
 Evidence X-RAY 3pqz C Reference
       Region 3pqz C 416-429 disorder
       Region 3pqz C 430-488 order
       Region 3pqz C 489-489 disorder
       Region 3pqz C 490-527 order
       Region 3pqz C 528-532 disorder
Seq 423-529 Hetero dimer :
 Evidence X-RAY 4x6s B Reference
       Region 4x6s B 423-529 order
Seq 423-529 Hetero dimer :
 Evidence X-RAY 4x6s A Reference
       Region 4x6s A 423-423 disorder
       Region 4x6s A 424-529 order
Seqphosphorylation
    188-188 Phosphotyrosine; by FAK1
    338-338 Phosphotyrosine; by FAK1
    361-361 Phosphoserine
 
Prediction
NeProc
Disorder 1-95,203-218,359-436
Order 96-202,219-358,437-532
ProS 1-6,43-50,64-76,91-95,203-218,359-371,382-410,426-436
AlphaFold
Disorder 1-39,44-99,193-195,206-213,242-243,352-371,399-423
Order 40-43,100-192,196-205,214-241,244-351,372-398,424-532
Pfam Hmmer
PF00788 100-186 4.8e-21
PF00169 230-338 4.2e-15
PF00017 431-512 1.5e-22
SEG 2-17 ,19-36
Function
Function in SwissProt
Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration. Plays a role in the assembly and stability of RNA stress granules. Binds to the 5'UTR of target mRNA molecules and represses translation of target mRNA species, when not phosphorylated. Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery after cellular stress (By similarity).
Biological Process
See also
Diagram with PDB data
ERBB2/GRB7Water refined solution structure of the human Grb7-SH2 domain in complex with the 10 amino acid peptide pY1139