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IID00567
 UniprotQ14498
ProteinRNA-binding protein 39
GeneRBM39
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
530
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 73-99 Hetero dimer : IID00094Complex
 Evidence X-RAY 4oo6 B Reference
       Region 4oo6 B 73-91 disorder
       Region 4oo6 B 92-99 order
Seq 144-234 Monomer :
 Evidence X-RAY 4yud A Reference
       Region 4yud A 144-229 order
       Region 4yud A 230-234 disorder
 Evidence NMR 2mhn A Reference
       Region 2mhn A 144-234 order
       Region 2mhn A 144-144 high_rmsd
       Region 2mhn A 189-191 high_rmsd
       Region 2mhn A 231-234 high_rmsd
Seq 235-331 Monomer :
 Evidence NMR 2jrs A Reference
       Region 2jrs A 235-331 order
       Region 2jrs A 235-247 high_rmsd
       Region 2jrs A 328-331 high_rmsd
Seq 417-530 Homo dimer :
 Evidence X-RAY 4oz0 B Reference
       Region 4oz0 B 417-420 disorder
       Region 4oz0 B 421-528 order
       Region 4oz0 B 529-530 disorder
 Evidence X-RAY 4oz0 A Reference
       Region 4oz0 A 417-417 disorder
       Region 4oz0 A 418-530 order
Seq 417-530 Hetero trimer : IID00190Complex
 Evidence X-RAY 4oz1 B Reference
       Region 4oz1 B 417-419 disorder
       Region 4oz1 B 420-529 order
       Region 4oz1 B 530-530 disorder
 Evidence X-RAY 4oz1 A Reference
       Region 4oz1 A 417-417 disorder
       Region 4oz1 A 418-528 order
       Region 4oz1 A 529-530 disorder
Seqphosphorylation
    341-341 Phosphoserine
    95-95 Phosphotyrosine
    97-97 Phosphoserine
    100-100 Phosphoserine
    117-117 Phosphoserine
    121-121 Phosphoserine
    136-136 Phosphoserine
    146-146 Phosphothreonine
    334-334 Phosphoserine
    337-337 Phosphoserine
Seqacetylation
    2-2 N-acetylalanine
 
Prediction
NeProc
Disorder 1-148,231-247,332-422,523-530
Order 149-230,248-331,423-522
ProS 1-18,36-44,70-76,86-99,106-113,231-236,337-370,523-526
AlphaFold
Disorder 1-145,235-248,327-354,356-356,360-360,364-421,435-435,438-439,528-530
Order 146-234,249-326,355-355,357-359,361-363,422-434,436-437,440-527
Pfam Hmmer
PF00076 155-225 9.8e-13
PF00076 252-323 8.2e-32
SEG 28-90 ,117-136 ,332-345 ,369-380 ,403-422 ,481-487
Function
Function in SwissProt
RNA-binding protein that acts as a pre-mRNA splicing factor (PubMed:15694343, PubMed:31271494, PubMed:28437394, PubMed:28302793, PubMed:24795046). Acts by promoting exon inclusion via regulation of exon cassette splicing (PubMed:31271494). Also acts as a transcriptional coactivator for steroid nuclear receptors ESR1/ER-alpha and ESR2/ER-beta, and JUN/AP-1, independently of the pre-mRNA splicing factor activity (By similarity).