Search Keyword:


Search option:


IID00570
 UniprotQ6PL18
ProteinATPase family AAA domain-containing protein 2
GeneATAD2
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1390
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 981-1108 Hetero dimer :
 Evidence X-RAY 4tt2 A Reference
       Region 4tt2 A 981-1108 order
Seq 981-1108 Homo dimer :
 Evidence X-RAY 5a5r A Reference
       Region 5a5r A 981-1108 order
Seq 981-1108 Hetero dimer : IID00058Complex
 Evidence X-RAY 4quu A Reference
       Region 4quu A 981-1108 order
Seq 981-1108 Monomer :
 Evidence X-RAY 5lj0 A Reference
       Region 5lj0 A 981-1108 order
 Evidence X-RAY 5a83 A Reference
       Region 5a83 A 981-1108 order
 Evidence X-RAY 5a82 A Reference
       Region 5a82 A 981-1108 order
 Evidence X-RAY 5a81 A Reference
       Region 5a81 A 981-1108 order
 Evidence X-RAY 5a5p A Reference
       Region 5a5p A 981-1108 order
 Evidence X-RAY 4tz8 A Reference
       Region 4tz8 A 981-1108 order
 Evidence X-RAY 4tz2 A Reference
       Region 4tz2 A 981-1108 order
 Evidence X-RAY 4tyl A Reference
       Region 4tyl A 981-1108 order
 Evidence X-RAY 4tu6 D Reference
       Region 4tu6 D 981-1108 order
 Evidence X-RAY 4tu6 C Reference
       Region 4tu6 C 981-1107 order
       Region 4tu6 C 1108-1108 disorder
 Evidence X-RAY 4tu6 B Reference
       Region 4tu6 B 981-1108 order
 Evidence X-RAY 4tu6 A Reference
       Region 4tu6 A 981-1108 order
 Evidence X-RAY 4tu4 A Reference
       Region 4tu4 A 981-1108 order
 Evidence X-RAY 4tte A Reference
       Region 4tte A 981-1108 order
 Evidence X-RAY 4tt6 A Reference
       Region 4tt6 A 981-1108 order
 Evidence X-RAY 4qsx A Reference
       Region 4qsx A 981-1108 order
 Evidence X-RAY 4qsw A Reference
       Region 4qsw A 981-1108 order
 Evidence X-RAY 4qsv A Reference
       Region 4qsv A 981-1108 order
 Evidence X-RAY 4qsu A Reference
       Region 4qsu A 981-1108 order
 Evidence X-RAY 4qst A Reference
       Region 4qst A 981-1108 order
 Evidence X-RAY 4qss A Reference
       Region 4qss A 981-1108 order
 Evidence X-RAY 4qsr A Reference
       Region 4qsr A 981-1108 order
 Evidence X-RAY 4qsq A Reference
       Region 4qsq A 981-1108 order
 Evidence X-RAY 4qsp A Reference
       Region 4qsp A 981-1108 order
 Evidence X-RAY 5f3a A Reference
       Region 5f3a A 981-1108 order
 Evidence X-RAY 5f36 A Reference
       Region 5f36 A 981-1108 order
 Evidence X-RAY 5epb A Reference
       Region 5epb A 981-1108 order
 Evidence X-RAY 3dai A Reference
       Region 3dai A 981-1108 order
 Evidence X-RAY 5a5q A Reference
       Region 5a5q A 981-1108 order
 Evidence X-RAY 5a5o A Reference
       Region 5a5o A 981-1108 order
 Evidence X-RAY 5a5n A Reference
       Region 5a5n A 981-1108 order
Seq 981-1108 Hetero dimer : IID00058Complex
 Evidence X-RAY 4qut A Reference
       Region 4qut A 981-1108 order
Seq 981-1108 Hetero trimer :
 Evidence X-RAY 4tt4 A Reference
       Region 4tt4 A 981-1108 order
 Evidence X-RAY 4tt4 B Reference
       Region 4tt4 B 981-1108 order
Seqphosphorylation
    1139-1139 Phosphoserine
    60-60 Phosphoserine
    61-61 Phosphoserine
    165-165 Phosphoserine
    170-170 Phosphoserine
    327-327 Phosphoserine
    337-337 Phosphoserine
    342-342 Phosphoserine
    410-410 Phosphoserine
    746-746 Phosphoserine
    751-751 Phosphoserine
    1149-1149 Phosphothreonine
    1323-1323 Phosphothreonine
    1302-1302 Phosphoserine
    1243-1243 Phosphoserine
    1235-1235 Phosphoserine
    1233-1233 Phosphoserine
    1200-1200 Phosphoserine
    1176-1176 Phosphothreonine
    1152-1152 Phosphothreonine
 
Prediction
NeProc
Disorder 1-413,743-789,958-971,1116-1324
Order 414-742,790-941,947-957,972-1111,1325-1390
ProS 1-9,21-31,75-81,97-106,119-124,149-184,217-220,292-325,340-363,369-378,384-413,743-762,774-789,1116-1124,1173-1179,1236-1251,1269-1273
AlphaFold
Disorder 1-175,199-421,488-489,564-565,726-788,949-956,958-958,967-968,1113-1315,1319-1323,1388-1390
Order 176-198,422-487,490-563,566-725,789-948,957-957,959-966,969-1112,1316-1318,1324-1387
Pfam Hmmer
PF00004 462-652 3.7e-83
PF00439 989-1080 2.7e-15
SEG 21-31 ,42-57 ,186-200 ,246-289 ,357-369 ,374-386 ,643-654 ,951-967
Function
Function in SwissProt
May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells.