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IID00571
 UniprotQ71RC2
ProteinLa-related protein 4
GeneLARP4
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
724
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 13-26 Hetero dimer : IID00193Complex
 Evidence X-RAY 3pkn B Reference
       Region 3pkn B 13-14 disorder
       Region 3pkn B 15-25 order
       Region 3pkn B 26-26 disorder
Seq 113-200 Monomer :
 Evidence NMR 2cqk A Reference
       Region 2cqk A 113-200 order
       Region 2cqk A 113-113 high_rmsd
       Region 2cqk A 199-200 high_rmsd
Seqphosphorylation
    392-392 Phosphoserine
    505-505 Phosphoserine
    578-578 Phosphothreonine
    579-579 Phosphothreonine
    583-583 Phosphoserine
    597-597 Phosphoserine
    647-647 Phosphoserine
    649-649 Phosphothreonine
    722-722 Phosphoserine
Seqacetylation
    1-1 N-acetylmethionine
 
Prediction
NeProc
Disorder 1-4,27-115,285-298,311-318,328-724
Order 5-26,116-284,299-310,319-327
ProS 1-4,41-47,55-74,333-353,372-382,439-444,452-462,477-483,504-510,614-617,673-676,691-705,710-724
AlphaFold
Disorder 1-114,276-477,489-616,624-724
Order 115-275,478-488,617-623
Pfam Hmmer
PF05383 123-180 8.7e-29
SEG 381-394 ,442-462
Function
Function in SwissProt
RNA binding protein that binds to the poly-A tract of mRNA molecules (PubMed:21098120). Associates with the 40S ribosomal subunit and with polysomes (PubMed:21098120). Plays a role in the regulation of mRNA translation (PubMed:21098120). Plays a role in the regulation of cell morphology and cytoskeletal organization (PubMed:21834987, PubMed:27615744).