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IID00573
 UniprotQ8IYD1
ProteinEukaryotic peptide chain release factor GTP-binding subunit ERF3B
GeneGSPT2
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
628
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 59-73 Hetero dimer : IID00193Complex
 Evidence X-RAY 3kuj B Reference
       Region 3kuj B 59-73 order
 
Prediction
NeProc
Disorder 1-199,565-570,628-628
Order 200-564,571-627
ProS 7-18,51-71,565-570
AlphaFold
Disorder 1-53,56-61,65-199,626-628
Order 54-55,62-64,200-625
Pfam Hmmer
PF07145 47-64 0.00024
PF00009 201-424 2.5e-94
PF03144 443-510 2.3e-11
PF03143 516-624 3.4e-32
SEG 2-10 ,155-191 ,316-327
Function
Function in SwissProt
Involved in translation termination in response to the termination codons UAA, UAG and UGA. May play a role as a potent stimulator of the release factor activity of ETF1. Exhibits GTPase activity, which is ribosome- and ETF1-dependent. May play a role in cell cycle progression. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons.