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IID00579
 UniprotQ99075
ProteinProheparin-binding EGF-like growth factor
GeneHBEGF
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
208
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 73-147 Hetero tetramer : P00588
 Evidence X-RAY 1xdt R Reference
       Region 1xdt R 73-106 disorder
       Region 1xdt R 107-147 order
Seq 185-208 Hetero dimer : IID50180Complex
 Evidence NMR 2m8s B Reference
       Region 2m8s B 185-208 order
Seqdisorder 186-208
 Evidence NMR Reference
       Region 186-208 disorder
SeqProS verified 186-208 Hetero dimer : IID50180Complex
       Region 2m8s B 185-208 order
       Region 186-208 disorder
 
Prediction
NeProc
Disorder 1-100,157-161,185-208
Order 101-156,162-184
ProS 1-43,52-100,157-161,185-208
AlphaFold
Disorder 1-3,22-104,149-157,190-196,207-208
Order 4-21,105-148,158-189,197-206
Pfam Hmmer
PF00008 108-143 1.8e-06
SEG 92-105 ,162-182
Function
Function in SwissProt
Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor.