Search Keyword:


Search option:


IID00580
 UniprotQ99700
ProteinAtaxin-2
GeneATXN2
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1313
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 912-928 Hetero dimer : IID00193Complex
 Evidence X-RAY 3ktr B Reference
       Region 3ktr B 912-912 disorder
       Region 3ktr B 913-928 order
Seqphosphorylation
    889-889 Phosphoserine
    888-888 Phosphoserine
    867-867 Phosphoserine
    642-642 Phosphoserine
    248-248 Phosphoserine
    393-393 Phosphoserine
    466-466 Phosphoserine
    478-478 Phosphoserine
    508-508 Phosphoserine
    554-554 Phosphoserine
    624-624 Phosphoserine
    865-865 Phosphoserine
    684-684 Phosphoserine
    728-728 Phosphoserine
    741-741 Phosphothreonine
    772-772 Phosphoserine
    784-784 Phosphoserine
    856-856 Phosphoserine
    857-857 Phosphoserine
    861-861 Phosphoserine
 
Prediction
NeProc
Disorder 1-259,318-321,377-393,457-1313
Order 260-313,322-376,394-456
ProS 19-41,74-110,126-129,136-140,146-160,457-495,913-925
AlphaFold
Disorder 1-165,185-256,313-318,344-369,371-371,375-395,468-468,474-785,805-1313
Order 166-184,257-312,319-343,370-370,372-374,396-467,469-473,786-804
Pfam Hmmer
PF06741 354-476 1.8e-66
PF07145 909-926 2.9e-06
SEG 2-12 ,33-74 ,87-127 ,141-154 ,166-188 ,199-246 ,378-390 ,551-571 ,575-607 ,666-681 ,721-736 ,847-871 ,893-908 ,925-947 ,1019-1033 ,1155-1192 ,1272-1288
Function
Function in SwissProt
Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane.