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IID00582
 UniprotQ9BPZ3
ProteinPolyadenylate-binding protein-interacting protein 2
GenePAIP2
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
127
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seqdisorder 106-127
 Evidence NMR Reference
       Region 106-127 disorder
Seq 106-127 Hetero dimer : IID00193Complex
 Evidence NMR 1jgn B Reference
       Region 1jgn B 106-127 order
       Region 1jgn B 106-106 high_rmsd
 Evidence X-RAY 3kus C Reference
       Region 3kus C 109-110 disorder
       Region 3kus C 111-121 order
       Region 3kus C 122-123 disorder
 Evidence X-RAY 3kus D Reference
       Region 3kus D 109-109 disorder
       Region 3kus D 110-123 order
 Evidence X-RAY 3kut C Reference
       Region 3kut C 109-109 disorder
       Region 3kut C 110-125 order
 Evidence X-RAY 3kut D Reference
       Region 3kut D 109-123 order
       Region 3kut D 124-125 disorder
SeqProS verified 111-121 Hetero dimer : IID00193Complex
       Region 1jgn B 106-127 order
       Region 3kus C 111-121 order
       Region 3kus D 110-123 order
       Region 3kut C 110-125 order
       Region 3kut D 109-123 order
       Region 106-127 disorder
 
Prediction
NeProc
Disorder 1-29,80-99
Order 30-79,100-127
ProS 1-23,80-99
AlphaFold
Disorder 1-27,71-106,126-127
Order 28-70,107-125
Pfam Hmmer
PF07145 106-123 1.2e-06
SEG 38-72
Function
Function in SwissProt
Acts as a repressor in the regulation of translation initiation of poly(A)-containing mRNAs. Its inhibitory activity on translation is mediated via its action on PABPC1. Displaces the interaction of PABPC1 with poly(A) RNA and competes with PAIP1 for binding to PABPC1. Its association with PABPC1 results in disruption of the cytoplasmic poly(A) RNP structure organization.