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IID00583
 UniprotQ9BQA1
ProteinMethylosome protein 50
GeneWDR77
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
342
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 2-342 Hetero dimer : IID00405Complex
 Evidence X-RAY 4x60 B Reference
       Region 4x60 B 2-18 disorder
       Region 4x60 B 19-328 order
       Region 4x60 B 329-342 disorder
 Evidence X-RAY 4x61 B Reference
       Region 4x61 B 2-23 disorder
       Region 4x61 B 24-207 order
       Region 4x61 B 208-210 disorder
       Region 4x61 B 211-328 order
       Region 4x61 B 329-342 disorder
 Evidence X-RAY 4x63 B Reference
       Region 4x63 B 2-19 disorder
       Region 4x63 B 20-328 order
       Region 4x63 B 329-342 disorder
 Evidence X-RAY 5c9z B Reference
       Region 5c9z B 2-15 disorder
       Region 5c9z B 16-328 order
       Region 5c9z B 329-342 disorder
Seq 2-342 Hetero dodecamer : IID00405Complex
 Evidence X-RAY 4gqb B Reference
       Region 4gqb B 2-20 disorder
       Region 4gqb B 21-207 order
       Region 4gqb B 208-211 disorder
       Region 4gqb B 212-244 order
       Region 4gqb B 245-246 disorder
       Region 4gqb B 247-329 order
       Region 4gqb B 330-342 disorder
Seq 2-342 Hetero octamer : IID00405Complex
 Evidence X-RAY 5emj B Reference
       Region 5emj B 2-25 disorder
       Region 5emj B 26-328 order
       Region 5emj B 329-342 disorder
 Evidence X-RAY 5emk B Reference
       Region 5emk B 2-15 disorder
       Region 5emk B 16-328 order
       Region 5emk B 329-342 disorder
 Evidence X-RAY 5eml B Reference
       Region 5eml B 2-18 disorder
       Region 5eml B 19-328 order
       Region 5eml B 329-342 disorder
 Evidence X-RAY 5emm B Reference
       Region 5emm B 2-15 disorder
       Region 5emm B 16-328 order
       Region 5emm B 329-342 disorder
Seq 2-342 Hetero trimer : IID00405Complex
 Evidence X-RAY 5fa5 B Reference
       Region 5fa5 B 2-20 disorder
       Region 5fa5 B 21-207 order
       Region 5fa5 B 208-211 disorder
       Region 5fa5 B 212-244 order
       Region 5fa5 B 245-247 disorder
       Region 5fa5 B 248-328 order
       Region 5fa5 B 329-342 disorder
Seqphosphorylation
    5-5 Phosphothreonine
 
Prediction
NeProc
Disorder 1-7,334-342
Order 8-333
ProS 4-7,334-342
AlphaFold
Disorder 1-16,208-211,245-245,330-342
Order 17-207,212-244,246-329
Pfam Hmmer
PF00400 157-196 1.1e-07
SEG 40-51
Function
Function in SwissProt
Non-catalytic component of the methylosome complex, composed of PRMT5, WDR77 and CLNS1A, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins and histones (PubMed:11756452). This modification targets Sm proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein core particles. Might play a role in transcription regulation. The methylosome complex also methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage (PubMed:23071334).