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IID00585
 UniprotQ9C004
ProteinProtein sprouty homolog 4
GeneSPRY4
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
299
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 46-58 Hetero dimer : IID00300Complex
 Evidence X-RAY 3bun A Reference
       Region 3bun A 46-49 disorder
       Region 3bun A 50-56 order
       Region 3bun A 57-58 disorder
Seqphosphorylation
    125-125 Phosphoserine
Seqacetylation
    1-1 N-acetylmethionine
 
Prediction
NeProc
Disorder 1-154,219-224,283-299
Order 155-218,225-282
ProS 20-58,125-132,219-224,283-286,296-299
AlphaFold
Disorder 1-37,39-39,41-42,44-153,212-217,228-228,286-299
Order 38-38,40-40,43-43,154-211,218-227,229-285
Pfam Hmmer
PF05210 33-276 4.4e-158
SEG 91-107 ,159-171
Function
Function in SwissProt
Suppresses the insulin receptor and EGFR-transduced MAPK signaling pathway, but does not inhibit MAPK activation by a constitutively active mutant Ras (PubMed:12027893). Probably impairs the formation of GTP-Ras (PubMed:12027893). Inhibits Ras-independent, but not Ras-dependent, activation of RAF1 (PubMed:12717443). Represses integrin-mediated cell spreading via inhibition of TESK1-mediated phosphorylation of cofilin (PubMed:15584898).