IDEAL List

IDEAL

IID00586
UniprotQ9H074
ProteinPolyadenylate-binding protein-interacting protein 1
GenePAIP1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
Network xml rdf

Structure

Experiment

:order disorder conflict PDB cluster ProS Pfam Domain SEG

479

order/disorder by at least rule

disorder by at least rule

order by at least rule

order/disorder by majority rule

Seq 123-144 Hetero dimer : IID00193Complex

Evidence NMR 1jh4 B Reference

Region 1jh4 B 123-144 order

Region 1jh4 B 123-124 high_rmsd

Region 1jh4 B 143-144 high_rmsd

Seq 123-144 Hetero dimer : Q62671

Evidence X-RAY 3ntw B Reference

Region 3ntw B 123-126 disorder

Region 3ntw B 127-138 order

Region 3ntw B 139-144 disorder

Evidence X-RAY 3ntw D Reference

Region 3ntw D 123-125 disorder

Region 3ntw D 126-139 order

Region 3ntw D 140-144 disorder

Seq 157-373 Monomer :

Evidence X-RAY 3rk6 A Reference

Region 3rk6 A 157-373 order

Evidence X-RAY 3rk6 B Reference

Region 3rk6 B 157-373 order

Seqacetylation

2-2 N-acetylalanine

Prediction

NeProc

Disorder 1-154,380-402,435-479

Order 155-230,236-379,403-434

ProS 1-10,41-45,127-140,395-402,435-479

AlphaFold

Disorder 1-128,133-133,138-155,381-391,430-457,479-479

Order 129-132,134-137,156-380,392-429,458-478

Pfam Hmmer

PF07145 123-140 0.00023

PF02854 159-376 2.4e-57

SEG 7-38 ,54-68 ,136-148 ,452-464

Function

Function in SwissProt

Acts as a coactivator in the regulation of translation initiation of poly(A)-containing mRNAs. Its stimulatory activity on translation is mediated via its action on PABPC1. Competes with PAIP2 for binding to PABPC1. Its association with EIF4A and PABPC1 may potentiate contacts between mRNA termini. May also be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain.