IID00587
Uniprot Q9HCJ0
Protein Trinucleotide repeat-containing gene 6C protein
Gene TNRC6C
Organism Homo sapiens
Sequence
LLPS
Network
xml
rdf
Structure
atLeast majority ProS Experiment
:order disorder conflict PDB cluster ProS Pfam Domain SEG
1690
order/disorder by at least rule
disorder by at least rule
order/disorder by majority rule
Region 2dkl A 927-998 order
Region 2dkl A 927-932 high_rmsd
Region 2dkl A 982-998 high_rmsd
Region 1380-1401 disorder
Seq 1380-1401 Hetero dimer : IID00193 Complex
Region 2x04 C 1382-1384 disorder
Region 2x04 C 1385-1399 order
Region 2x04 D 1382-1384 disorder
Region 2x04 D 1385-1399 order
Region 3ktp B 1380-1383 disorder
Region 3ktp B 1384-1399 order
Region 3ktp B 1400-1401 disorder
Seq ProS verified 1384-1399 Hetero dimer : IID00193 Complex
Region 3ktp B 1384-1399 order
Region 2x04 C 1385-1399 order
Region 2x04 D 1385-1399 order
Region 1380-1401 disorder
Prediction
Disorder 29-1384,1420-1771,1779-1785,1803-1936
Order 1-28,1385-1419,1772-1778,1786-1802
ProS 29-33,74-97,146-152,165-186,193-197,307-321,391-399,457-463,480-483,654-661,806-812,863-867,934-939,946-959,1033-1055,1105-1111,1121-1127,1140-1163,1186-1213,1223-1231,1470-1475,1505-1508,1549-1557,1572-1577,1588-1624,1635-1642,1685-1688,1706-1710,1747-1771,1779-1785,1803-1808,1813-1840,1891-1896,1902-1906,1921-1936
Disorder 1-936,978-1118,1129-1143,1174-1181,1210-1511,1595-1690
Order 937-977,1119-1128,1144-1173,1182-1209,1512-1594
PF00627 1146-1185 8.9e-09
SEG 2-26
,45-57
,218-235
,242-259
,298-318
,394-408
,437-453
,469-480
,594-614
,621-632
,720-730
,750-772
,801-814
,964-982
,1041-1052
,1113-1122
,1235-1257
,1298-1314
,1357-1383
,1402-1418
,1422-1436
,1562-1571
,1641-1649
,1654-1681
,1736-1756
,1844-1865
,1917-1933
Function
Function in SwissProt
Plays a role in RNA-mediated gene silencing by micro-RNAs (miRNAs). Required for miRNA-dependent translational repression of complementary mRNAs by argonaute family proteins. As scaffoldng protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes.