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IID00587
UniprotQ9HCJ0
ProteinTrinucleotide repeat-containing gene 6C protein
GeneTNRC6C
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1690
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 927-998 Monomer :
 Evidence NMR 2dkl A Reference
       Region 2dkl A 927-998 order
       Region 2dkl A 927-932 high_rmsd
       Region 2dkl A 982-998 high_rmsd
Seqdisorder 1380-1401
 Evidence NMR Reference
       Region 1380-1401 disorder
Seq 1380-1401 Hetero dimer : IID00193Complex
 Evidence X-RAY 2x04 C Reference
       Region 2x04 C 1382-1384 disorder
       Region 2x04 C 1385-1399 order
 Evidence X-RAY 2x04 D Reference
       Region 2x04 D 1382-1384 disorder
       Region 2x04 D 1385-1399 order
 Evidence X-RAY 3ktp B Reference
       Region 3ktp B 1380-1383 disorder
       Region 3ktp B 1384-1399 order
       Region 3ktp B 1400-1401 disorder
SeqProS verified 1384-1399 Hetero dimer : IID00193Complex
       Region 3ktp B 1384-1399 order
       Region 2x04 C 1385-1399 order
       Region 2x04 D 1385-1399 order
       Region 1380-1401 disorder
Seqphosphorylation
    675-675 Phosphoserine
    924-924 Phosphoserine
    987-987 Phosphothreonine
    1218-1218 Phosphoserine
 
Prediction
NeProc
Disorder 29-1384,1420-1771,1779-1785,1803-1936
Order 1-28,1385-1419,1772-1778,1786-1802
ProS 29-33,74-97,146-152,165-186,193-197,307-321,391-399,457-463,480-483,654-661,806-812,863-867,934-939,946-959,1033-1055,1105-1111,1121-1127,1140-1163,1186-1213,1223-1231,1470-1475,1505-1508,1549-1557,1572-1577,1588-1624,1635-1642,1685-1688,1706-1710,1747-1771,1779-1785,1803-1808,1813-1840,1891-1896,1902-1906,1921-1936
AlphaFold
Disorder 1-936,978-1118,1129-1143,1174-1181,1210-1511,1595-1690
Order 937-977,1119-1128,1144-1173,1182-1209,1512-1594
Pfam Hmmer
PF00627 1146-1185 8.9e-09
SEG 2-26 ,45-57 ,218-235 ,242-259 ,298-318 ,394-408 ,437-453 ,469-480 ,594-614 ,621-632 ,720-730 ,750-772 ,801-814 ,964-982 ,1041-1052 ,1113-1122 ,1235-1257 ,1298-1314 ,1357-1383 ,1402-1418 ,1422-1436 ,1562-1571 ,1641-1649 ,1654-1681 ,1736-1756 ,1844-1865 ,1917-1933
Function
Function in SwissProt
Plays a role in RNA-mediated gene silencing by micro-RNAs (miRNAs). Required for miRNA-dependent translational repression of complementary mRNAs by argonaute family proteins. As scaffoldng protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes.