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IID00590
 UniprotQ9UPN6
ProteinProtein SCAF8
GeneSCAF8
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1271
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-136 Hetero trimer : IID00126Complex
 Evidence X-RAY 3d9o A Reference
       Region 3d9o A 1-1 disorder
       Region 3d9o A 2-136 order
 Evidence X-RAY 3d9o B Reference
       Region 3d9o B 1-136 order
Seq 1-136 Hetero dimer : IID00126Complex
 Evidence X-RAY 3d9k A Reference
       Region 3d9k A 1-1 disorder
       Region 3d9k A 2-136 order
 Evidence X-RAY 3d9k B Reference
       Region 3d9k B 1-136 order
 Evidence X-RAY 3d9l A Reference
       Region 3d9l A 1-1 disorder
       Region 3d9l A 2-136 order
 Evidence X-RAY 3d9l B Reference
       Region 3d9l B 1-136 order
 Evidence X-RAY 3d9m A Reference
       Region 3d9m A 1-1 disorder
       Region 3d9m A 2-136 order
 Evidence X-RAY 3d9m B Reference
       Region 3d9m B 1-136 order
 Evidence X-RAY 3d9n A Reference
       Region 3d9n A 1-1 disorder
       Region 3d9n A 2-136 order
 Evidence X-RAY 3d9n B Reference
       Region 3d9n B 1-1 disorder
       Region 3d9n B 2-136 order
 Evidence X-RAY 3d9p A Reference
       Region 3d9p A 1-1 disorder
       Region 3d9p A 2-136 order
 Evidence X-RAY 3d9p B Reference
       Region 3d9p B 1-136 order
Seq 1-137 Monomer :
 Evidence NMR 2diw A Reference
       Region 2diw A 1-137 order
 Evidence X-RAY 3d9i A Reference
       Region 3d9i A 1-1 disorder
       Region 3d9i A 2-136 order
 Evidence X-RAY 3d9i B Reference
       Region 3d9i B 1-136 order
 Evidence X-RAY 3d9j A Reference
       Region 3d9j A 1-1 disorder
       Region 3d9j A 2-136 order
 Evidence X-RAY 3d9j B Reference
       Region 3d9j B 1-1 disorder
       Region 3d9j B 2-136 order
Seqphosphorylation
    779-779 Phosphoserine
    617-617 Phosphoserine
    615-615 Phosphothreonine
    273-273 Phosphoserine
    6-6 Phosphothreonine
 
Prediction
NeProc
Disorder 141-461,600-1271
Order 1-136,462-599
ProS 259-271,368-378,436-445,827-832,937-940,970-986,1012-1198,1206-1217,1233-1238,1257-1271
AlphaFold
Disorder 138-197,199-199,210-230,234-234,237-302,304-304,307-307,310-316,318-448,600-694,696-697,699-1149,1151-1151,1156-1156,1167-1167,1169-1271
Order 1-137,198-198,200-209,231-233,235-236,303-303,305-306,308-309,317-317,449-599,695-695,698-698,1150-1150,1152-1155,1157-1166,1168-1168
Pfam Hmmer
PF04818 56-124 0.0006
PF00076 479-546 7.4e-10
SEG 157-171 ,193-223 ,232-251 ,305-326 ,363-380 ,397-462 ,618-629 ,655-678 ,685-712 ,859-874 ,940-955 ,964-973 ,1029-1046 ,1149-1171 ,1258-1269
Function
Function in SwissProt
Anti-terminator protein required to prevent early mRNA termination during transcription (PubMed:31104839). Together with SCAF4, acts by suppressing the use of early, alternative poly(A) sites, thereby preventing the accumulation of non-functional truncated proteins (PubMed:31104839). Mechanistically, associates with the phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit (POLR2A), and subsequently binds nascent RNA upstream of early polyadenylation sites to prevent premature mRNA transcript cleavage and polyadenylation (PubMed:31104839). Independently of SCAF4, also acts as a positive regulator of transcript elongation (PubMed:31104839).