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IID00591
 UniprotQ9Y657
ProteinSpindlin-1
GeneSPIN1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
262
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 26-262 Homo dimer :
 Evidence X-RAY 2ns2 B Reference
       Region 2ns2 B 26-51 disorder
       Region 2ns2 B 52-116 order
       Region 2ns2 B 117-128 disorder
       Region 2ns2 B 129-140 order
       Region 2ns2 B 141-149 disorder
       Region 2ns2 B 150-193 order
       Region 2ns2 B 194-208 disorder
       Region 2ns2 B 209-259 order
       Region 2ns2 B 260-262 disorder
 Evidence X-RAY 2ns2 A Reference
       Region 2ns2 A 26-49 disorder
       Region 2ns2 A 50-195 order
       Region 2ns2 A 196-205 disorder
       Region 2ns2 A 206-260 order
       Region 2ns2 A 261-262 disorder
Seq 27-262 Hetero dimer : Q5TEC6
 Evidence X-RAY 4h75 A Reference
       Region 4h75 A 27-44 disorder
       Region 4h75 A 45-194 order
       Region 4h75 A 195-210 disorder
       Region 4h75 A 211-259 order
       Region 4h75 A 260-262 disorder
Seq 50-262 Hetero dimer : IID00088Complex
 Evidence X-RAY 4mzf B Reference
       Region 4mzf B 50-193 order
       Region 4mzf B 194-211 disorder
       Region 4mzf B 212-259 order
       Region 4mzf B 260-262 disorder
 Evidence X-RAY 4mzg B Reference
       Region 4mzg B 50-195 order
       Region 4mzg B 196-211 disorder
       Region 4mzg B 212-259 order
       Region 4mzg B 260-262 disorder
 Evidence X-RAY 4mzg D Reference
       Region 4mzg D 50-195 order
       Region 4mzg D 196-209 disorder
       Region 4mzg D 210-220 order
       Region 4mzg D 221-227 disorder
       Region 4mzg D 228-259 order
       Region 4mzg D 260-262 disorder
 Evidence X-RAY 4mzh A Reference
       Region 4mzh A 50-193 order
       Region 4mzh A 194-211 disorder
       Region 4mzh A 212-222 order
       Region 4mzh A 223-224 disorder
       Region 4mzh A 225-259 order
       Region 4mzh A 260-262 disorder
Seq 50-262 Monomer :
 Evidence X-RAY 5jsg A Reference
       Region 5jsg A 50-194 order
       Region 5jsg A 195-210 disorder
       Region 5jsg A 211-222 order
       Region 5jsg A 223-227 disorder
       Region 5jsg A 228-259 order
       Region 5jsg A 260-262 disorder
 Evidence X-RAY 5jsg B Reference
       Region 5jsg B 50-194 order
       Region 5jsg B 195-211 disorder
       Region 5jsg B 212-259 order
       Region 5jsg B 260-262 disorder
 Evidence X-RAY 5jsj A Reference
       Region 5jsj A 50-195 order
       Region 5jsj A 196-211 disorder
       Region 5jsj A 212-259 order
       Region 5jsj A 260-262 disorder
 Evidence X-RAY 5jsj B Reference
       Region 5jsj B 50-194 order
       Region 5jsj B 195-210 disorder
       Region 5jsj B 211-259 order
       Region 5jsj B 260-262 disorder
Seq 51-262 Hetero heptamer :
 Evidence X-RAY 5y5w A Reference
       Region 5y5w A 51-194 order
       Region 5y5w A 195-210 disorder
       Region 5y5w A 211-259 order
       Region 5y5w A 260-262 disorder
 Evidence X-RAY 5y5w B Reference
       Region 5y5w B 51-114 order
       Region 5y5w B 115-125 disorder
       Region 5y5w B 126-194 order
       Region 5y5w B 195-211 disorder
       Region 5y5w B 212-259 order
       Region 5y5w B 260-262 disorder
 Evidence X-RAY 5y5w C Reference
       Region 5y5w C 51-194 order
       Region 5y5w C 195-211 disorder
       Region 5y5w C 212-259 order
       Region 5y5w C 260-262 disorder
 Evidence X-RAY 5y5w D Reference
       Region 5y5w D 51-194 order
       Region 5y5w D 195-210 disorder
       Region 5y5w D 211-259 order
       Region 5y5w D 260-262 disorder
Seqphosphorylation
    109-109 Phosphoserine; by AURKA
    124-124 Phosphoserine; by AURKA
    199-199 Phosphoserine
Seqacetylation
    44-44 N6-acetyllysine; alternate
 
Prediction
NeProc
Disorder 1-53,58-68
Order 54-57,69-117,122-262
ProS 1-8,16-25,49-53,58-68
AlphaFold
Disorder 1-50,196-210,260-262
Order 51-195,211-259
Pfam Hmmer
PF02513 54-103 4.7e-31
PF02513 133-182 4e-27
PF02513 214-259 9.1e-24
SEG 28-39
Function
Function in SwissProt
Chromatin reader that specifically recognizes and binds histone H3 both trimethylated at 'Lys-4' and asymmetrically dimethylated at 'Arg-8' (H3K4me3 and H3R8me2a) and acts as an activator of Wnt signaling pathway downstream of PRMT2. In case of cancer, promotes cell cancer proliferation via activation of the Wnt signaling pathway (PubMed:24589551). Overexpression induces metaphase arrest and chromosomal instability. Localizes to active rDNA loci and promotes the expression of rRNA genes (PubMed:21960006). May play a role in cell-cycle regulation during the transition from gamete to embryo. Involved in oocyte meiotic resumption, a process that takes place before ovulation to resume meiosis of oocytes blocked in prophase I: may act by regulating maternal transcripts to control meiotic resumption.