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IID00592
 UniprotP68036
ProteinUbiquitin-conjugating enzyme E2 L3
GeneUBE2L3
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
154
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-154 Hetero dimer : Q9Y4X5
 Evidence X-RAY 5udh D Reference
       Region 5udh D 1-153 order
       Region 5udh D 154-154 disorder
Seq 1-154 Hetero trimer : P0CG63,Q3YTH2
 Evidence X-RAY 4q5h C Reference
       Region 4q5h C 1-154 order
 Evidence X-RAY 4q5e C Reference
       Region 4q5e C 1-154 order
Seq 1-154 Hetero trimer : Q9Y4X5
 Evidence X-RAY 5udh C Reference
       Region 5udh C 1-151 order
       Region 5udh C 152-154 disorder
Seq 1-154 Hetero trimer : P69326,Q9Y4X5
 Evidence X-RAY 5tte E Reference
       Region 5tte E 1-3 disorder
       Region 5tte E 4-154 order
Seq 1-154 Hetero tetramer : IID00209Complex
 Evidence X-RAY 1c4z D Reference
       Region 1c4z D 1-3 disorder
       Region 1c4z D 4-147 order
       Region 1c4z D 148-154 disorder
Seq 1-154 Hetero dimer : Q8ZNR3
 Evidence X-RAY 3sy2 C Reference
       Region 3sy2 C 1-154 order
 Evidence X-RAY 3sy2 D Reference
       Region 3sy2 D 1-154 order
Seq 1-154 Hetero dimer : A0A0H3JDV8
 Evidence X-RAY 3sqv D Reference
       Region 3sqv D 1-150 order
       Region 3sqv D 151-154 disorder
 Evidence X-RAY 3sqv C Reference
       Region 3sqv C 1-48 order
       Region 3sqv C 49-50 disorder
       Region 3sqv C 51-147 order
       Region 3sqv C 148-154 disorder
Seq 1-154 Hetero trimer : IID00300Complex
 Evidence X-RAY 1fbv C Reference
       Region 1fbv C 1-3 disorder
       Region 1fbv C 4-147 order
       Region 1fbv C 148-154 disorder
Seq 2-154 Hetero octamer : Q9H0M0
 Evidence X-RAY 5hpt F Reference
       Region 5hpt F 2-151 order
       Region 5hpt F 152-154 disorder
 Evidence X-RAY 5hpt C Reference
       Region 5hpt C 2-152 order
       Region 5hpt C 153-154 disorder
Seqacetylation
    131-131 N6-acetyllysine
 
Prediction
NeProc
Disorder 1-3,150-154
Order 4-149
ProS 150-154
AlphaFold
Disorder 1-1
Order 2-154
Pfam Hmmer
PF00179 6-144 2.1e-65
SEG 61-75
Function
Function in SwissProt
Ubiquitin-conjugating enzyme E2 that specifically acts with HECT-type and RBR family E3 ubiquitin-protein ligases. Does not function with most RING-containing E3 ubiquitin-protein ligases because it lacks intrinsic E3-independent reactivity with lysine: in contrast, it has activity with the RBR family E3 enzymes, such as PRKN and ARIH1, that function like RING-HECT hybrids. Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-linked polyubiquitination. Involved in the selective degradation of short-lived and abnormal proteins. Down-regulated during the S-phase it is involved in progression through the cell cycle. Regulates nuclear hormone receptors transcriptional activity. May play a role in myelopoiesis.