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IID00593
 UniprotQ15080
ProteinNeutrophil cytosol factor 4
GeneNCF4
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
339
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-339 Monomer :
 Evidence X-RAY 2dyb B Reference
       Region 2dyb B 1-8 disorder
       Region 2dyb B 9-74 order
       Region 2dyb B 75-77 disorder
       Region 2dyb B 78-90 order
       Region 2dyb B 91-95 disorder
       Region 2dyb B 96-149 order
       Region 2dyb B 150-172 disorder
       Region 2dyb B 173-231 order
       Region 2dyb B 232-234 disorder
       Region 2dyb B 235-289 order
       Region 2dyb B 290-292 disorder
       Region 2dyb B 293-309 order
       Region 2dyb B 310-319 disorder
       Region 2dyb B 320-328 order
       Region 2dyb B 329-339 disorder
 Evidence X-RAY 2dyb A Reference
       Region 2dyb A 1-8 disorder
       Region 2dyb A 9-74 order
       Region 2dyb A 75-83 disorder
       Region 2dyb A 84-153 order
       Region 2dyb A 154-168 disorder
       Region 2dyb A 169-330 order
       Region 2dyb A 331-339 disorder
Seq 2-144 Monomer :
 Evidence X-RAY 1h6h A Reference
       Region 1h6h A 2-144 order
Seq 168-233 Monomer :
 Evidence NMR 1z9q A Reference
       Region 1z9q A 168-233 order
 Evidence X-RAY 1w6x B Reference
       Region 1w6x B 174-228 order
 Evidence X-RAY 1w6x A Reference
       Region 1w6x A 174-228 order
Seq 174-228 Hetero dimer : IID00597Complex
 Evidence X-RAY 1w70 B Reference
       Region 1w70 B 174-228 order
 Evidence X-RAY 1w70 A Reference
       Region 1w70 A 174-228 order
Seq 237-339 Hetero dimer : IID00299Complex
 Evidence X-RAY 1oey M Reference
       Region 1oey M 237-311 order
       Region 1oey M 312-316 disorder
       Region 1oey M 317-339 order
 Evidence X-RAY 1oey L Reference
       Region 1oey L 237-312 order
       Region 1oey L 313-317 disorder
       Region 1oey L 318-339 order
 Evidence X-RAY 1oey K Reference
       Region 1oey K 237-339 order
 Evidence X-RAY 1oey J Reference
       Region 1oey J 237-339 order
SeqProS verified 329-339 Hetero dimer : IID00299Complex
       Region 1oey J 237-339 order
       Region 1oey K 237-339 order
       Region 1oey L 318-339 order
       Region 1oey M 317-339 order
       Region 2dyb B 329-339 disorder
Seqphosphorylation
    154-154 Phosphothreonine
    315-315 Phosphoserine
 
Prediction
NeProc
Disorder 1-13,136-166,232-237
Order 14-135,167-231,238-339
ProS 1-13,136-166
AlphaFold
Disorder 1-1,3-9,78-81,93-96,146-170,201-201,203-205,231-236,338-339
Order 2-2,10-77,82-92,97-145,171-200,202-202,206-230,237-337
Pfam Hmmer
PF00787 18-136 3.1e-30
PF00018 173-227 1.1e-14
PF00564 237-329 2.6e-15
Function
Function in SwissProt
Component of the NADPH-oxidase, a multicomponent enzyme system responsible for the oxidative burst in which electrons are transported from NADPH to molecular oxygen, generating reactive oxidant intermediates. It may be important for the assembly and/or activation of the NADPH-oxidase complex.