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IID00595
 UniprotQ9HCG8
ProteinPre-mRNA-splicing factor CWC22 homolog
GeneCWC22
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
908
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 116-406 Hetero dimer : IID00370Complex
 Evidence X-RAY 4c9b B Reference
       Region 4c9b B 116-122 disorder
       Region 4c9b B 123-141 order
       Region 4c9b B 142-148 disorder
       Region 4c9b B 149-406 order
Seqphosphorylation
    39-39 Phosphoserine
    61-61 Phosphoserine
    107-107 Phosphoserine
    786-786 Phosphoserine
    829-829 Phosphoserine
 
Prediction
NeProc
Disorder 1-134,142-151,406-442,654-908
Order 135-141,152-405,443-653
ProS 4-18,27-50,71-77,83-86,119-134,142-151,406-410,670-673,774-780,839-843,875-882,896-908
AlphaFold
Disorder 1-132,134-134,142-143,145-147,326-326,407-446,650-908
Order 133-133,135-141,144-144,148-325,327-406,447-649
Pfam Hmmer
PF02854 163-346 1.2e-38
PF02847 455-561 1.8e-25
SEG 38-53 ,69-99 ,170-191 ,271-283 ,423-439 ,666-714 ,755-765
Function
Function in SwissProt
Required for pre-mRNA splicing as component of the spliceosome (PubMed:12226669, PubMed:11991638, PubMed:22961380, PubMed:28502770, PubMed:28076346, PubMed:29360106, PubMed:29301961). Promotes exon-junction complex (EJC) assembly (PubMed:22959432, PubMed:22961380). Hinders EIF4A3 from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs. Through its role in EJC assembly, required for nonsense-mediated mRNA decay.