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IID00597
 UniprotP14598
ProteinNeutrophil cytosol factor 1
GeneNCF1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
390
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-123 Homo trimer :
 Evidence X-RAY 1o7k C Reference
       Region 1o7k C 1-3 disorder
       Region 1o7k C 4-123 order
 Evidence X-RAY 1o7k B Reference
       Region 1o7k B 1-3 disorder
       Region 1o7k B 4-123 order
 Evidence X-RAY 1o7k A Reference
       Region 1o7k A 1-123 order
Seq 1-141 Monomer :
 Evidence NMR 1gd5 A Reference
       Region 1gd5 A 1-128 order
 Evidence X-RAY 1kq6 A Reference
       Region 1kq6 A 1-1 disorder
       Region 1kq6 A 2-141 order
Seq 151-286 Hetero dimer : IID00596Complex
 Evidence NMR 1wlp B Reference
       Region 1wlp B 151-286 order
Seq 151-340 Monomer :
 Evidence X-RAY 1uec A Reference
       Region 1uec A 151-156 disorder
       Region 1uec A 157-169 order
       Region 1uec A 170-172 disorder
       Region 1uec A 173-336 order
       Region 1uec A 337-340 disorder
 Evidence X-RAY 1ng2 A Reference
       Region 1ng2 A 156-156 disorder
       Region 1ng2 A 157-332 order
       Region 1ng2 A 333-340 disorder
Seq 156-285 Hetero tetramer :
 Evidence X-RAY 1ov3 B Reference
       Region 1ov3 B 156-217 order
       Region 1ov3 B 218-222 disorder
       Region 1ov3 B 223-283 order
       Region 1ov3 B 284-285 disorder
 Evidence X-RAY 1ov3 A Reference
       Region 1ov3 A 156-283 order
       Region 1ov3 A 284-285 disorder
Seq 359-390 Hetero dimer : IID00299Complex
 Evidence NMR 1k4u P Reference
       Region 1k4u P 359-390 order
Seq 360-372 Hetero dimer : IID00593Complex
 Evidence X-RAY 1w70 D Reference
       Region 1w70 D 360-369 order
       Region 1w70 D 370-372 disorder
 Evidence X-RAY 1w70 C Reference
       Region 1w70 C 360-372 order
Seqphosphorylation
    303-303 Phosphoserine
    304-304 Phosphoserine
    320-320 Phosphoserine
    345-345 Phosphoserine
    328-328 Phosphoserine
    348-348 Phosphoserine
 
Prediction
NeProc
Disorder 127-156,214-227,287-390
Order 1-122,157-213,228-286
ProS 130-142,303-310,363-390
AlphaFold
Disorder 1-2,80-82,127-134,143-157,339-366,374-374,378-378,381-381,385-390
Order 3-79,83-126,135-142,158-338,367-373,375-377,379-380,382-384
Pfam Hmmer
PF00787 4-121 6.1e-25
PF00018 159-213 5.9e-18
PF00018 229-283 1.3e-16
SEG 333-346
Function
Function in SwissProt
NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production).
Biological Process
See also
Diagram with PDB data
CYBA/NCF1Solution Structure Of The P22Phox-P47Phox Complex