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IID00600
 UniprotQ5TBB1
ProteinRibonuclease H2 subunit B
GeneRNASEH2B
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
312
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 2-233 Hetero trimer : IID00601Complex,IID00602Complex
 Evidence X-RAY 3puf Q Reference
       Region 3puf Q 14-22 order
       Region 3puf Q 23-34 disorder
       Region 3puf Q 35-107 order
       Region 3puf Q 108-108 disorder
       Region 3puf Q 109-145 order
       Region 3puf Q 146-153 disorder
       Region 3puf Q 154-185 order
       Region 3puf Q 186-208 disorder
       Region 3puf Q 209-232 order
       Region 3puf Q 233-233 disorder
 Evidence X-RAY 3puf N Reference
       Region 3puf N 14-25 order
       Region 3puf N 26-34 disorder
       Region 3puf N 35-145 order
       Region 3puf N 146-150 disorder
       Region 3puf N 151-187 order
       Region 3puf N 188-205 disorder
       Region 3puf N 206-230 order
       Region 3puf N 231-233 disorder
 Evidence X-RAY 3puf K Reference
       Region 3puf K 14-24 order
       Region 3puf K 25-34 disorder
       Region 3puf K 35-145 order
       Region 3puf K 146-152 disorder
       Region 3puf K 153-184 order
       Region 3puf K 185-206 disorder
       Region 3puf K 207-232 order
       Region 3puf K 233-233 disorder
 Evidence X-RAY 3puf H Reference
       Region 3puf H 14-146 order
       Region 3puf H 147-151 disorder
       Region 3puf H 152-189 order
       Region 3puf H 190-203 disorder
       Region 3puf H 204-232 order
       Region 3puf H 233-233 disorder
 Evidence X-RAY 3puf E Reference
       Region 3puf E 14-26 order
       Region 3puf E 27-30 disorder
       Region 3puf E 31-142 order
       Region 3puf E 143-153 disorder
       Region 3puf E 154-183 order
       Region 3puf E 184-203 disorder
       Region 3puf E 204-228 order
       Region 3puf E 229-233 disorder
 Evidence X-RAY 3puf B Reference
       Region 3puf B 14-24 order
       Region 3puf B 25-34 disorder
       Region 3puf B 35-148 order
       Region 3puf B 149-152 disorder
       Region 3puf B 153-184 order
       Region 3puf B 185-204 disorder
       Region 3puf B 205-231 order
       Region 3puf B 232-233 disorder
 Evidence X-RAY 3p56 E Reference
       Region 3p56 E 2-11 disorder
       Region 3p56 E 12-28 order
       Region 3p56 E 29-33 disorder
       Region 3p56 E 34-44 order
       Region 3p56 E 45-48 disorder
       Region 3p56 E 49-106 order
       Region 3p56 E 107-122 disorder
       Region 3p56 E 123-142 order
       Region 3p56 E 143-153 disorder
       Region 3p56 E 154-184 order
       Region 3p56 E 185-205 disorder
       Region 3p56 E 206-226 order
 Evidence X-RAY 3p56 B Reference
       Region 3p56 B 2-11 disorder
       Region 3p56 B 12-28 order
       Region 3p56 B 29-34 disorder
       Region 3p56 B 35-44 order
       Region 3p56 B 45-49 disorder
       Region 3p56 B 50-106 order
       Region 3p56 B 107-122 disorder
       Region 3p56 B 123-142 order
       Region 3p56 B 143-153 disorder
       Region 3p56 B 154-184 order
       Region 3p56 B 185-205 disorder
       Region 3p56 B 206-226 order
Seq 290-312 Hetero hexamer : IID00022Complex
 Evidence X-RAY 3p87 L Reference
       Region 3p87 L 290-290 disorder
       Region 3p87 L 291-301 order
       Region 3p87 L 302-312 disorder
 Evidence X-RAY 3p87 J Reference
       Region 3p87 J 290-290 disorder
       Region 3p87 J 291-301 order
       Region 3p87 J 302-312 disorder
 Evidence X-RAY 3p87 H Reference
       Region 3p87 H 290-301 order
       Region 3p87 H 302-312 disorder
 Evidence X-RAY 3p87 K Reference
       Region 3p87 K 290-301 order
       Region 3p87 K 302-312 disorder
 Evidence X-RAY 3p87 I Reference
       Region 3p87 I 290-301 order
       Region 3p87 I 302-312 disorder
 Evidence X-RAY 3p87 G Reference
       Region 3p87 G 290-290 disorder
       Region 3p87 G 291-301 order
       Region 3p87 G 302-312 disorder
SeqProS possible 290-301 PIP box motif Hetero hexamer : IID00022Complex
       Region 3p87 G 291-301 order
       Region 3p87 H 290-301 order
       Region 3p87 I 290-301 order
       Region 3p87 J 291-301 order
       Region 3p87 K 290-301 order
       Region 3p87 L 291-301 order
Seqphosphorylation
    296-296 Phosphoserine
Seqacetylation
    2-2 N-acetylalanine
    295-295 N6-acetyllysine
 
Prediction
NeProc
Disorder 1-11,193-199,243-312
Order 12-25,33-192,200-241
ProS 6-11,193-199,243-252,285-304,309-312
AlphaFold
Disorder 1-12,27-32,147-151,187-203,234-279,304-312
Order 13-26,33-146,152-186,204-233,280-303
SEG 2-13 ,127-138
Function
Function in SwissProt
Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.