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IID00601
 UniprotO75792
ProteinRibonuclease H2 subunit A
GeneRNASEH2A
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
299
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-299 Hetero trimer : IID00600Complex,IID00602Complex
 Evidence X-RAY 3puf P Reference
       Region 3puf P 1-4 disorder
       Region 3puf P 5-197 order
       Region 3puf P 198-206 disorder
       Region 3puf P 207-257 order
       Region 3puf P 258-284 disorder
       Region 3puf P 285-299 order
 Evidence X-RAY 3puf M Reference
       Region 3puf M 1-1 disorder
       Region 3puf M 2-257 order
       Region 3puf M 258-283 disorder
       Region 3puf M 284-299 order
 Evidence X-RAY 3puf J Reference
       Region 3puf J 1-2 disorder
       Region 3puf J 3-84 order
       Region 3puf J 85-86 disorder
       Region 3puf J 87-199 order
       Region 3puf J 200-200 disorder
       Region 3puf J 201-259 order
       Region 3puf J 260-283 disorder
       Region 3puf J 284-299 order
 Evidence X-RAY 3puf G Reference
       Region 3puf G 1-8 disorder
       Region 3puf G 9-258 order
       Region 3puf G 259-283 disorder
       Region 3puf G 284-299 order
 Evidence X-RAY 3puf D Reference
       Region 3puf D 1-1 disorder
       Region 3puf D 2-259 order
       Region 3puf D 260-283 disorder
       Region 3puf D 284-299 order
 Evidence X-RAY 3puf A Reference
       Region 3puf A 1-200 order
       Region 3puf A 201-203 disorder
       Region 3puf A 204-257 order
       Region 3puf A 258-283 disorder
       Region 3puf A 284-299 order
 Evidence X-RAY 3p56 D Reference
       Region 3p56 D 1-9 disorder
       Region 3p56 D 10-66 order
       Region 3p56 D 67-69 disorder
       Region 3p56 D 70-84 order
       Region 3p56 D 85-86 disorder
       Region 3p56 D 87-142 order
       Region 3p56 D 143-166 disorder
       Region 3p56 D 167-194 order
       Region 3p56 D 195-204 disorder
       Region 3p56 D 205-257 order
       Region 3p56 D 258-283 disorder
       Region 3p56 D 284-299 order
 Evidence X-RAY 3p56 A Reference
       Region 3p56 A 1-9 disorder
       Region 3p56 A 10-66 order
       Region 3p56 A 67-69 disorder
       Region 3p56 A 70-84 order
       Region 3p56 A 85-86 disorder
       Region 3p56 A 87-194 order
       Region 3p56 A 195-204 disorder
       Region 3p56 A 205-257 order
       Region 3p56 A 258-283 disorder
       Region 3p56 A 284-299 order
Seqphosphorylation
    277-277 Phosphoserine
    257-257 Phosphoserine
    216-216 Phosphothreonine
    204-204 Phosphothreonine
Seqacetylation
    1-1 N-acetylmethionine
 
Prediction
NeProc
Disorder 1-5,259-283,296-299
Order 6-258,284-295
ProS 1-5,267-273,296-299
AlphaFold
Disorder 66-69,198-202,258-284
Order 1-65,70-197,203-257,285-299
Pfam Hmmer
PF01351 31-241 4.1e-55
Function
Function in SwissProt
Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.