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IID00602
 UniprotQ8TDP1
ProteinRibonuclease H2 subunit C
GeneRNASEH2C
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
164
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-164 Hetero trimer : IID00600Complex,IID00601Complex
 Evidence X-RAY 3puf R Reference
       Region 3puf R 1-9 disorder
       Region 3puf R 10-17 order
       Region 3puf R 18-24 disorder
       Region 3puf R 25-86 order
       Region 3puf R 87-116 disorder
       Region 3puf R 117-161 order
       Region 3puf R 162-164 disorder
 Evidence X-RAY 3puf O Reference
       Region 3puf O 1-8 disorder
       Region 3puf O 9-16 order
       Region 3puf O 17-24 disorder
       Region 3puf O 25-86 order
       Region 3puf O 87-117 disorder
       Region 3puf O 118-163 order
       Region 3puf O 164-164 disorder
 Evidence X-RAY 3puf L Reference
       Region 3puf L 1-9 disorder
       Region 3puf L 10-17 order
       Region 3puf L 18-21 disorder
       Region 3puf L 22-87 order
       Region 3puf L 88-119 disorder
       Region 3puf L 120-161 order
       Region 3puf L 162-164 disorder
 Evidence X-RAY 3puf I Reference
       Region 3puf I 1-6 disorder
       Region 3puf I 7-22 order
       Region 3puf I 23-23 disorder
       Region 3puf I 24-92 order
       Region 3puf I 93-107 disorder
       Region 3puf I 108-162 order
       Region 3puf I 163-164 disorder
 Evidence X-RAY 3puf F Reference
       Region 3puf F 1-7 disorder
       Region 3puf F 8-88 order
       Region 3puf F 89-115 disorder
       Region 3puf F 116-162 order
       Region 3puf F 163-164 disorder
 Evidence X-RAY 3puf C Reference
       Region 3puf C 1-7 disorder
       Region 3puf C 8-88 order
       Region 3puf C 89-116 disorder
       Region 3puf C 117-162 order
       Region 3puf C 163-164 disorder
 Evidence X-RAY 3p56 F Reference
       Region 3p56 F 1-13 disorder
       Region 3p56 F 14-86 order
       Region 3p56 F 87-117 disorder
       Region 3p56 F 118-160 order
       Region 3p56 F 161-164 disorder
 Evidence X-RAY 3p56 C Reference
       Region 3p56 C 1-13 disorder
       Region 3p56 C 14-86 order
       Region 3p56 C 87-117 disorder
       Region 3p56 C 118-160 order
       Region 3p56 C 161-164 disorder
Seqphosphorylation
    3-3 Phosphoserine
Seqacetylation
    1-1 N-acetylmethionine
 
Prediction
NeProc
Disorder 1-24,90-116,160-164
Order 25-89,117-159
ProS 1-5,11-20,160-164
AlphaFold
Disorder 1-10,90-112
Order 11-89,113-164
Pfam Hmmer
PF08615 27-155 2.1e-55
Function
Function in SwissProt
Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.