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IID00603
 UniprotP24864
ProteinG1/S-specific cyclin-E1
GeneCCNE1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
410
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 96-378 Hetero dimer : IID00034Complex
 Evidence X-RAY 1w98 B Reference
       Region 1w98 B 96-102 disorder
       Region 1w98 B 103-372 order
       Region 1w98 B 373-378 disorder
 Evidence X-RAY 5l2w B Reference
       Region 5l2w B 96-102 disorder
       Region 5l2w B 103-372 order
       Region 5l2w B 373-378 disorder
Seqphosphorylation
    399-399 Phosphoserine; by CDK2
    387-387 Phosphoserine
    395-395 Phosphothreonine; by GSK3
    103-103 Phosphoserine
    77-77 Phosphothreonine
 
Prediction
NeProc
Disorder 1-101,380-410
Order 102-379
ProS 24-27,33-48,54-63,69-76,88-101,387-401
AlphaFold
Disorder 1-100,386-410
Order 101-385
Pfam Hmmer
PF00134 115-242 4.6e-59
PF02984 244-370 1.4e-21
SEG 3-14 ,281-292
Function
Function in SwissProt
Essential for the control of the cell cycle at the G1/S (start) transition.
Biological Process
See also
Diagram with PDB data
RB1/E2F1/TFDP1Structure of the Rb C-terminal domain bound to an E2F1-DP1 heterodimer
RBL1/E2F5/TFDP1Crystal structure of the E2F5-DP1-p107 ternary complex