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IID00606
 UniprotQ9NR80
ProteinRho guanine nucleotide exchange factor 4
GeneARHGEF4
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
690
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 143-632 Monomer :
 Evidence X-RAY 2dx1 A Reference
       Region 2dx1 A 143-184 disorder
       Region 2dx1 A 185-255 order
       Region 2dx1 A 256-276 disorder
       Region 2dx1 A 277-555 order
       Region 2dx1 A 556-568 disorder
       Region 2dx1 A 569-576 order
       Region 2dx1 A 577-582 disorder
       Region 2dx1 A 583-609 order
       Region 2dx1 A 610-611 disorder
 Evidence X-RAY 2pz1 A Reference
       Region 2pz1 A 170-180 disorder
       Region 2pz1 A 181-254 order
       Region 2pz1 A 255-277 disorder
       Region 2pz1 A 278-611 order
       Region 2pz1 A 612-632 disorder
Seq 170-194 Hetero dimer : IID00035Complex
 Evidence X-RAY 3nmx D Reference
       Region 3nmx D 170-179 disorder
       Region 3nmx D 180-192 order
       Region 3nmx D 193-194 disorder
 Evidence X-RAY 3nmx E Reference
       Region 3nmx E 170-179 disorder
       Region 3nmx E 180-192 order
       Region 3nmx E 193-194 disorder
 Evidence X-RAY 3nmx F Reference
       Region 3nmx F 170-179 disorder
       Region 3nmx F 180-192 order
       Region 3nmx F 193-194 disorder
Seq 170-276 Hetero dimer : IID00035Complex
 Evidence X-RAY 3nmz C Reference
       Region 3nmz C 170-170 disorder
       Region 3nmz C 171-255 order
       Region 3nmz C 256-276 disorder
 Evidence X-RAY 3nmz D Reference
       Region 3nmz D 170-171 disorder
       Region 3nmz D 172-255 order
       Region 3nmz D 256-276 disorder
 
Prediction
NeProc
Disorder 1-190,254-277,617-690
Order 191-253,278-616
ProS 1-5,28-41,64-75,112-136,146-157,179-190,617-631,650-690
AlphaFold
Disorder 1-71,79-79,81-183,185-185,208-208,256-277,512-512,579-579,634-690
Order 72-78,80-80,184-184,186-207,209-255,278-511,513-578,580-633
Pfam Hmmer
PF00018 197-251 2.9e-12
PF00621 288-467 4.5e-39
PF00169 500-606 1.5e-12
SEG 169-182
Function
Function in SwissProt
Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Binding of APC may activate RAC1 GEF activity. The APC-ARHGEF4 complex seems to be involved in cell migration as well as in E-cadherin-mediated cell-cell adhesion. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression.