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IID00607
 UniprotO15492
ProteinRegulator of G-protein signaling 16
GeneRGS16
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
202
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 53-190 Monomer :
 Evidence X-RAY 2bt2 E Reference
       Region 2bt2 E 53-187 order
       Region 2bt2 E 188-190 disorder
 Evidence X-RAY 2bt2 D Reference
       Region 2bt2 D 53-187 order
       Region 2bt2 D 188-190 disorder
 Evidence X-RAY 2bt2 C Reference
       Region 2bt2 C 53-186 order
       Region 2bt2 C 187-190 disorder
 Evidence X-RAY 2bt2 B Reference
       Region 2bt2 B 53-187 order
       Region 2bt2 B 188-190 disorder
 Evidence X-RAY 2bt2 A Reference
       Region 2bt2 A 53-188 order
       Region 2bt2 A 189-190 disorder
Seq 53-190 Hetero dimer : IID00608Complex
 Evidence X-RAY 2ik8 D Reference
       Region 2ik8 D 53-54 disorder
       Region 2ik8 D 55-184 order
       Region 2ik8 D 185-190 disorder
 Evidence X-RAY 2ik8 B Reference
       Region 2ik8 B 53-64 disorder
       Region 2ik8 B 65-184 order
       Region 2ik8 B 185-190 disorder
Seqphosphorylation
    168-168 Phosphotyrosine; by EGFR
    177-177 Phosphotyrosine
 
Prediction
NeProc
Disorder 33-53,184-202
Order 1-32,54-183
ProS 33-36,193-202
AlphaFold
Disorder 1-47,194-202
Order 48-193
Pfam Hmmer
PF00615 65-181 3.5e-44
SEG 180-196
Function
Function in SwissProt
Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:11602604, PubMed:18434541). Plays an important role in the phototransduction cascade by regulating the lifetime and effective concentration of activated transducin alpha. May regulate extra and intracellular mitogenic signals (By similarity).