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IID00609
 UniprotQ08116
ProteinRegulator of G-protein signaling 1
GeneRGS1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
209
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 63-205 Hetero dimer : IID00608Complex
 Evidence X-RAY 2gtp C Reference
       Region 2gtp C 63-72 disorder
       Region 2gtp C 73-204 order
       Region 2gtp C 205-205 disorder
 Evidence X-RAY 2gtp D Reference
       Region 2gtp D 63-72 disorder
       Region 2gtp D 73-204 order
       Region 2gtp D 205-205 disorder
Seq 63-205 Monomer :
 Evidence X-RAY 2bv1 B Reference
       Region 2bv1 B 63-71 disorder
       Region 2bv1 B 72-201 order
       Region 2bv1 B 202-205 disorder
 Evidence X-RAY 2bv1 A Reference
       Region 2bv1 A 63-70 disorder
       Region 2bv1 A 71-204 order
       Region 2bv1 A 205-205 disorder
 
Prediction
NeProc
Disorder 1-74,204-209
Order 75-203
ProS 6-21,29-36,43-61
AlphaFold
Disorder 1-6,8-13,15-16,18-48,59-59,61-72,208-209
Order 7-7,14-14,17-17,49-58,60-60,73-207
Pfam Hmmer
PF00615 85-200 3.1e-60
Function
Function in SwissProt
Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the N-formylpeptide chemoattractant receptors and leukotriene receptors (PubMed:10480894). Inhibits B cell chemotaxis toward CXCL12 (By similarity). Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form (PubMed:10480894, PubMed:18434541).