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IID00610
 UniprotQ13085
ProteinAcetyl-CoA carboxylase 1
GeneACACA
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
2346
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 78-617 Monomer :
 Evidence X-RAY 2yl2 B Reference
       Region 2yl2 B 78-101 disorder
       Region 2yl2 B 102-269 order
       Region 2yl2 B 270-274 disorder
       Region 2yl2 B 275-511 order
       Region 2yl2 B 512-523 disorder
       Region 2yl2 B 524-543 order
       Region 2yl2 B 544-555 disorder
       Region 2yl2 B 556-616 order
       Region 2yl2 B 617-617 disorder
 Evidence X-RAY 2yl2 A Reference
       Region 2yl2 A 78-101 disorder
       Region 2yl2 A 102-267 order
       Region 2yl2 A 268-277 disorder
       Region 2yl2 A 278-511 order
       Region 2yl2 A 512-523 disorder
       Region 2yl2 A 524-543 order
       Region 2yl2 A 544-555 disorder
       Region 2yl2 A 556-617 order
Seq 1258-1270 Hetero dimer : IID00042Complex
 Evidence X-RAY 3coj O Reference
       Region 3coj O 1258-1260 disorder
       Region 3coj O 1261-1267 order
       Region 3coj O 1268-1270 disorder
 Evidence X-RAY 3coj N Reference
       Region 3coj N 1258-1261 disorder
       Region 3coj N 1262-1266 order
       Region 3coj N 1267-1270 disorder
 Evidence X-RAY 3coj M Reference
       Region 3coj M 1258-1260 disorder
       Region 3coj M 1261-1267 order
       Region 3coj M 1268-1270 disorder
 Evidence X-RAY 3coj L Reference
       Region 3coj L 1258-1260 disorder
       Region 3coj L 1261-1270 order
 Evidence X-RAY 3coj K Reference
       Region 3coj K 1258-1270 order
 Evidence X-RAY 3coj J Reference
       Region 3coj J 1258-1260 disorder
       Region 3coj J 1261-1270 order
 Evidence X-RAY 3coj I Reference
       Region 3coj I 1258-1260 disorder
       Region 3coj I 1261-1270 order
 Evidence X-RAY 3coj H Reference
       Region 3coj H 1258-1260 disorder
       Region 3coj H 1261-1270 order
Seq 1571-2338 Homo dimer :
 Evidence X-RAY 4asi F Reference
       Region 4asi F 1571-1582 disorder
       Region 4asi F 1583-2278 order
       Region 4asi F 2279-2287 disorder
       Region 4asi F 2288-2309 order
       Region 4asi F 2310-2338 disorder
 Evidence X-RAY 4asi E Reference
       Region 4asi E 1571-1582 disorder
       Region 4asi E 1583-2278 order
       Region 4asi E 2279-2285 disorder
       Region 4asi E 2286-2310 order
       Region 4asi E 2311-2338 disorder
 Evidence X-RAY 4asi D Reference
       Region 4asi D 1571-1580 disorder
       Region 4asi D 1581-2279 order
       Region 4asi D 2280-2286 disorder
       Region 4asi D 2287-2325 order
       Region 4asi D 2326-2330 disorder
       Region 4asi D 2331-2337 order
       Region 4asi D 2338-2338 disorder
 Evidence X-RAY 4asi B Reference
       Region 4asi B 1571-1580 disorder
       Region 4asi B 1581-2279 order
       Region 4asi B 2280-2285 disorder
       Region 4asi B 2286-2324 order
       Region 4asi B 2325-2338 disorder
 Evidence X-RAY 4asi C Reference
       Region 4asi C 1571-1580 disorder
       Region 4asi C 1581-2279 order
       Region 4asi C 2280-2282 disorder
       Region 4asi C 2283-2338 order
 Evidence X-RAY 4asi A Reference
       Region 4asi A 1571-1580 disorder
       Region 4asi A 1581-2279 order
       Region 4asi A 2280-2286 disorder
       Region 4asi A 2287-2338 order
Seqphosphorylation
    5-5 Phosphoserine
    23-23 Phosphoserine
    25-25 Phosphoserine
    29-29 Phosphoserine
    34-34 Phosphoserine
    48-48 Phosphoserine
    50-50 Phosphoserine
    53-53 Phosphoserine
    58-58 Phosphothreonine
    78-78 Phosphoserine
    80-80 Phosphoserine
    488-488 Phosphoserine
    610-610 Phosphothreonine
    835-835 Phosphoserine
    1201-1201 Phosphoserine
    1216-1216 Phosphoserine
    1218-1218 Phosphoserine
    1227-1227 Phosphothreonine
    1259-1259 Phosphoserine
    1263-1263 Phosphoserine
    1273-1273 Phosphoserine
    2153-2153 Phosphothreonine
Seqacetylation
    1-1 N-acetylmethionine
    1334-1334 N6-acetyllysine
 
Prediction
NeProc
Disorder 1-92,1191-1226,1261-1283,2153-2157,2343-2346
Order 93-1188,1227-1260,1284-2152,2158-2342
ProS 18-26,72-92,1208-1221,1269-1274
AlphaFold
Disorder 1-100,271-278,315-319,731-731,784-787,811-811,826-828,840-846,932-933,1050-1055,1086-1092,1094-1094,1109-1118,1125-1129,1186-1187,1189-1189,1191-1230,1258-1283,1297-1298,1334-1351,1397-1397,1429-1437,1624-1626,1858-1859,2280-2285,2337-2346
Order 101-270,279-314,320-730,732-783,788-810,812-825,829-839,847-931,934-1049,1056-1085,1093-1093,1095-1108,1119-1124,1130-1185,1188-1188,1190-1190,1231-1257,1284-1296,1299-1333,1352-1396,1398-1428,1438-1623,1627-1857,1860-2279,2286-2336
Pfam Hmmer
PF00289 117-240 2.1e-59
PF02786 268-477 5.6e-58
PF02785 507-614 2.4e-53
PF00364 752-818 2.2e-23
PF01039 1664-2223 6.1e-294
SEG 175-190 ,709-726 ,2160-2173
Function
Function in SwissProt
Cytosolic enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis (PubMed:20952656, PubMed:20457939, PubMed:29899443). This is a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA (PubMed:20952656, PubMed:20457939, PubMed:29899443).