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IID00611
 UniprotQ6PJG6
ProteinBRCA1-associated ATM activator 1
GeneBRAT1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
821
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 268-273 Hetero dimer : IID00042Complex
 Evidence X-RAY 4ifi B Reference
       Region 4ifi B 268-273 order
Seqphosphorylation
    742-742 Phosphoserine
 
Prediction
NeProc
Disorder 181-186,334-366,759-762
Order 1-175,187-333,367-405,411-758,763-821
ProS 338-366,759-762
AlphaFold
Disorder 22-24,178-189,273-276,333-347,440-441,481-491,579-590,668-686,733-752,757-768,792-792,795-796,810-821
Order 1-21,25-177,190-272,277-332,348-439,442-480,492-578,591-667,687-732,753-756,769-791,793-794,797-809
Pfam Hmmer
PF02985 495-531 2.7e-06
SEG 93-110 ,339-356 ,700-712
Function
Function in SwissProt
Involved in DNA damage response; activates kinases ATM, SMC1A and PRKDC by modulating their phosphorylation status following ionizing radiation (IR) stress (PubMed:16452482, PubMed:22977523). Plays a role in regulating mitochondrial function and cell proliferation (PubMed:25070371). Required for protein stability of MTOR and MTOR-related proteins, and cell cycle progress by growth factors (PubMed:25657994).