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IID00612
 UniprotP20585
ProteinDNA mismatch repair protein Msh3
GeneMSH3
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1137
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 219-1134 Hetero dimer : IID00048Complex
 Evidence X-RAY 3thz B Reference
       Region 3thz B 219-224 disorder
       Region 3thz B 225-346 order
       Region 3thz B 347-360 disorder
       Region 3thz B 361-375 order
       Region 3thz B 376-380 disorder
       Region 3thz B 381-478 order
       Region 3thz B 479-490 disorder
       Region 3thz B 491-942 order
       Region 3thz B 943-947 disorder
       Region 3thz B 948-1034 order
       Region 3thz B 1035-1051 disorder
       Region 3thz B 1052-1123 order
       Region 3thz B 1124-1134 disorder
 Evidence X-RAY 3thy B Reference
       Region 3thy B 219-225 disorder
       Region 3thy B 226-350 order
       Region 3thy B 351-352 disorder
       Region 3thy B 353-375 order
       Region 3thy B 376-384 disorder
       Region 3thy B 385-478 order
       Region 3thy B 479-490 disorder
       Region 3thy B 491-941 order
       Region 3thy B 942-949 disorder
       Region 3thy B 950-1035 order
       Region 3thy B 1036-1051 disorder
       Region 3thy B 1052-1129 order
       Region 3thy B 1130-1134 disorder
 Evidence X-RAY 3thx B Reference
       Region 3thx B 219-225 disorder
       Region 3thx B 226-350 order
       Region 3thx B 351-352 disorder
       Region 3thx B 353-375 order
       Region 3thx B 376-384 disorder
       Region 3thx B 385-477 order
       Region 3thx B 478-491 disorder
       Region 3thx B 492-939 order
       Region 3thx B 940-949 disorder
       Region 3thx B 950-1035 order
       Region 3thx B 1036-1052 disorder
       Region 3thx B 1053-1129 order
       Region 3thx B 1130-1134 disorder
 Evidence X-RAY 3thw B Reference
       Region 3thw B 219-224 disorder
       Region 3thw B 225-350 order
       Region 3thw B 351-352 disorder
       Region 3thw B 353-377 order
       Region 3thw B 378-380 disorder
       Region 3thw B 381-478 order
       Region 3thw B 479-490 disorder
       Region 3thw B 491-942 order
       Region 3thw B 943-947 disorder
       Region 3thw B 948-1034 order
       Region 3thw B 1035-1051 disorder
       Region 3thw B 1052-1123 order
       Region 3thw B 1124-1134 disorder
Seqphosphorylation
    1099-1099 Phosphothreonine
    33-33 Phosphoserine
 
Prediction
NeProc
Disorder 1-226,1105-1106,1113-1137
Order 227-343,351-356,363-1039,1043-1104,1107-1112
ProS 21-30,165-179,191-202,1105-1106,1113-1137
AlphaFold
Disorder 1-226,350-353,376-382,449-449,478-489,875-875,899-900,941-950,1033-1054,1066-1067,1130-1137
Order 227-349,354-375,383-448,450-477,490-874,876-898,901-940,951-1032,1055-1065,1068-1129
Pfam Hmmer
PF01624 230-343 5.8e-47
PF05188 366-523 1.8e-44
PF05192 532-843 6.7e-27
PF00488 846-1096 7.4e-120
SEG 6-19 ,30-42 ,51-73 ,97-107
Function
Function in SwissProt
Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta which binds to DNA mismatches thereby initiating DNA repair. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. MutS beta recognizes large insertion-deletion loops (IDL) up to 13 nucleotides long. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis.
Biological Process
See also
Diagram with PDB data
MSH2/MSH3/DNAHuman MutSbeta complexed with an IDL of 4 bases (Loop4) and ADP