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IID00613
 UniprotQ15831
ProteinSerine/threonine-protein kinase STK11
GeneSTK11
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
433
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 43-347 Hetero trimer : IID00217Complex,Q9Y376
 Evidence X-RAY 2wtk C Reference
       Region 2wtk C 43-46 disorder
       Region 2wtk C 47-120 order
       Region 2wtk C 121-123 disorder
       Region 2wtk C 124-315 order
       Region 2wtk C 316-316 disorder
       Region 2wtk C 317-325 order
       Region 2wtk C 326-329 disorder
       Region 2wtk C 330-332 order
       Region 2wtk C 333-335 disorder
       Region 2wtk C 336-342 order
       Region 2wtk C 343-347 disorder
 Evidence X-RAY 2wtk F Reference
       Region 2wtk F 43-44 disorder
       Region 2wtk F 45-119 order
       Region 2wtk F 120-124 disorder
       Region 2wtk F 125-257 order
       Region 2wtk F 258-261 disorder
       Region 2wtk F 262-270 order
       Region 2wtk F 271-272 disorder
       Region 2wtk F 273-276 order
       Region 2wtk F 277-281 disorder
       Region 2wtk F 282-315 order
       Region 2wtk F 316-316 disorder
       Region 2wtk F 317-324 order
       Region 2wtk F 325-335 disorder
       Region 2wtk F 336-340 order
       Region 2wtk F 341-347 disorder
Seq 331-343 Hetero tetramer : IID00061Complex
 Evidence X-RAY 5wxn D Reference
       Region 5wxn D 331-331 disorder
       Region 5wxn D 332-341 order
       Region 5wxn D 342-343 disorder
 Evidence X-RAY 5wxn C Reference
       Region 5wxn C 331-331 disorder
       Region 5wxn C 332-341 order
       Region 5wxn C 342-343 disorder
Seq 333-340 Hetero tetramer : IID00061Complex
 Evidence X-RAY 4zdr B Reference
       Region 4zdr B 333-336 order
       Region 4zdr B 337-340 disorder
 Evidence X-RAY 4zdr A Reference
       Region 4zdr A 333-340 order
Seqphosphorylation
    31-31 Phosphoserine
    189-189 Phosphothreonine; by autocatalysis
    325-325 Phosphoserine
    336-336 Phosphothreonine; by autocatalysis
    363-363 Phosphothreonine; by ATM and autocatalysis
    401-401 Phosphoserine
    428-428 Phosphoserine; by autocatalysis
    399-399 Phosphoserine
Seqacetylation
    44-44 N6-acetyllysine
    48-48 N6-acetyllysine
    96-96 N6-acetyllysine
    97-97 N6-acetyllysine
    296-296 N6-acetyllysine
    311-311 N6-acetyllysine
    416-416 N6-acetyllysine
    423-423 N6-acetyllysine
    431-431 N6-acetyllysine
 
Prediction
NeProc
Disorder 1-2,31-37,323-433
Order 3-30,41-322
ProS 1-2,31-37,323-345,351-399,415-433
AlphaFold
Disorder 1-28,34-39,347-433
Order 29-33,40-346
Pfam Hmmer
PF00069 49-309 7.3e-67
SEG 78-88 ,180-190 ,314-326 ,348-361
Function
Function in SwissProt
Has a role in spermiogenesis.
Biological Process
Diagram with PDB data
STK11/CAB39/STRADAStructure of the heterotrimeric LKB1-STRADalpha-MO25alpha complex
STK11/YWHAZStructure of the LKB1 and 14-3-3 complex
See also
Diagram with PDB data
PRKAA2/PRKAB1/PRKAG1Structure of full length human AMPK in complex with a small molecule activator, a benzimidazole derivative (991)