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IID00620
 UniprotQ8N2Z9
ProteinCentromere protein S
GeneCENPS
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
138
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-114 Hetero pentamer : IID00424Complex,IID00484Complex
 Evidence X-RAY 4e45 M Reference
       Region 4e45 M 1-7 disorder
       Region 4e45 M 8-100 order
       Region 4e45 M 101-110 disorder
 Evidence X-RAY 4e45 K Reference
       Region 4e45 K 1-8 disorder
       Region 4e45 K 9-102 order
       Region 4e45 K 103-110 disorder
 Evidence X-RAY 4e45 H Reference
       Region 4e45 H 1-11 disorder
       Region 4e45 H 12-105 order
       Region 4e45 H 106-110 disorder
 Evidence X-RAY 4e45 F Reference
       Region 4e45 F 1-3 disorder
       Region 4e45 F 4-105 order
       Region 4e45 F 106-110 disorder
 Evidence X-RAY 4e45 C Reference
       Region 4e45 C 1-11 disorder
       Region 4e45 C 12-105 order
       Region 4e45 C 106-110 disorder
 Evidence X-RAY 4e45 A Reference
       Region 4e45 A 1-3 disorder
       Region 4e45 A 4-105 order
       Region 4e45 A 106-110 disorder
 Evidence X-RAY 4drb H Reference
       Region 4drb H 1-12 disorder
       Region 4drb H 13-106 order
       Region 4drb H 107-114 disorder
 Evidence X-RAY 4drb G Reference
       Region 4drb G 1-3 disorder
       Region 4drb G 4-108 order
       Region 4drb G 109-114 disorder
 Evidence X-RAY 4drb E Reference
       Region 4drb E 1-8 disorder
       Region 4drb E 9-105 order
       Region 4drb E 106-114 disorder
 Evidence X-RAY 4drb D Reference
       Region 4drb D 1-8 disorder
       Region 4drb D 9-105 order
       Region 4drb D 106-114 disorder
 Evidence X-RAY 4drb B Reference
       Region 4drb B 1-4 disorder
       Region 4drb B 5-107 order
       Region 4drb B 108-114 disorder
 Evidence X-RAY 4drb A Reference
       Region 4drb A 1-11 disorder
       Region 4drb A 12-109 order
       Region 4drb A 110-114 disorder
Seq 1-118 Hetero tetramer : IID00424Complex
 Evidence X-RAY 4ne6 C Reference
       Region 4ne6 C 14-105 order
 Evidence X-RAY 4ne6 A Reference
       Region 4ne6 A 14-105 order
 Evidence X-RAY 4ne5 G Reference
       Region 4ne5 G 14-105 order
 Evidence X-RAY 4ne5 C Reference
       Region 4ne5 C 14-105 order
 Evidence X-RAY 4ne5 E Reference
       Region 4ne5 E 14-105 order
 Evidence X-RAY 4ne5 A Reference
       Region 4ne5 A 14-105 order
 Evidence X-RAY 4ne3 A Reference
       Region 4ne3 A 14-105 order
 Evidence X-RAY 4ne1 J Reference
       Region 4ne1 J 14-106 order
       Region 4ne1 J 107-118 disorder
 Evidence X-RAY 4ne1 I Reference
       Region 4ne1 I 14-118 order
 Evidence X-RAY 4ne1 f Reference
       Region 4ne1 f 14-106 order
       Region 4ne1 f 107-118 disorder
 Evidence X-RAY 4ne1 e Reference
       Region 4ne1 e 14-118 order
 Evidence X-RAY 4ne1 G Reference
       Region 4ne1 G 14-106 order
       Region 4ne1 G 107-118 disorder
 Evidence X-RAY 4ne1 C Reference
       Region 4ne1 C 14-106 order
       Region 4ne1 C 107-118 disorder
 Evidence X-RAY 4ndy J Reference
       Region 4ndy J 14-105 order
 Evidence X-RAY 4ndy I Reference
       Region 4ndy I 14-105 order
 Evidence X-RAY 4e44 C Reference
       Region 4e44 C 1-8 disorder
       Region 4e44 C 9-105 order
       Region 4e44 C 106-110 disorder
 Evidence X-RAY 4e44 A Reference
       Region 4e44 A 1-102 order
       Region 4e44 A 103-110 disorder
 Evidence X-RAY 4dra C Reference
       Region 4dra C 1-6 disorder
       Region 4dra C 7-104 order
       Region 4dra C 105-107 disorder
 Evidence X-RAY 4dra B Reference
       Region 4dra B 1-12 disorder
       Region 4dra B 13-107 order
 Evidence X-RAY 4dra D Reference
       Region 4dra D 1-10 disorder
       Region 4dra D 11-103 order
       Region 4dra D 104-107 disorder
 Evidence X-RAY 4dra A Reference
       Region 4dra A 1-12 disorder
       Region 4dra A 13-105 order
       Region 4dra A 106-107 disorder
Seq 14-118 Hetero tetramer : IID00424Complex
 Evidence X-RAY 4ne1 l Reference
       Region 4ne1 l 14-106 order
       Region 4ne1 l 107-118 disorder
 Evidence X-RAY 4ne1 R Reference
       Region 4ne1 R 14-106 order
       Region 4ne1 R 107-118 disorder
 Evidence X-RAY 4ne1 Q Reference
       Region 4ne1 Q 14-118 order
 Evidence X-RAY 4ne1 T Reference
       Region 4ne1 T 14-118 order
 Evidence X-RAY 4ne1 K Reference
       Region 4ne1 K 14-118 order
 Evidence X-RAY 4ne1 T Reference
       Region 4ne1 T 14-118 order
 Evidence X-RAY 4ne1 K Reference
       Region 4ne1 K 14-118 order
 Evidence X-RAY 4ndy R Reference
       Region 4ndy R 14-105 order
 Evidence X-RAY 4ndy Q Reference
       Region 4ndy Q 14-105 order
Seq 14-118 Hetero tetramer : IID00424Complex
 Evidence X-RAY 4ne1 S Reference
       Region 4ne1 S 14-106 order
       Region 4ne1 S 107-118 disorder
 Evidence X-RAY 4ne1 A Reference
       Region 4ne1 A 14-106 order
       Region 4ne1 A 107-118 disorder
 Evidence X-RAY 4ndy S Reference
       Region 4ndy S 14-105 order
 Evidence X-RAY 4ndy A Reference
       Region 4ndy A 14-105 order
Seq 14-118 Hetero tetramer : IID00424Complex
 Evidence X-RAY 4ne1 n Reference
       Region 4ne1 n 14-118 order
 Evidence X-RAY 4ne1 g Reference
       Region 4ne1 g 14-118 order
 Evidence X-RAY 4ndy T Reference
       Region 4ndy T 14-105 order
 Evidence X-RAY 4ndy K Reference
       Region 4ndy K 14-105 order
Seq 14-118 Hetero tetramer : IID00424Complex
 Evidence X-RAY 4ne1 m Reference
       Region 4ne1 m 14-106 order
       Region 4ne1 m 107-118 disorder
 Evidence X-RAY 4ne1 Y Reference
       Region 4ne1 Y 14-106 order
       Region 4ne1 Y 107-118 disorder
 Evidence X-RAY 4ndy G Reference
       Region 4ndy G 14-105 order
 Evidence X-RAY 4ndy C Reference
       Region 4ndy C 14-105 order
Seqacetylation
    1-1 N-acetylmethionine
 
Prediction
NeProc
Disorder 1-12,103-138
Order 13-102
AlphaFold
Disorder 119-138
Order 1-118
SEG 2-9
Function
Function in SwissProt
DNA-binding component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage (PubMed:20347428, PubMed:20347429). In complex with CENPX (MHF heterodimer), crucial cofactor for FANCM in both binding and ATP-dependent remodeling of DNA. Stabilizes FANCM (PubMed:20347428, PubMed:20347429). In complex with CENPX and FANCM (but not other FANC proteins), rapidly recruited to blocked forks and promotes gene conversion at blocked replication forks (PubMed:20347428). In complex with CENPT, CENPW and CENPX (CENP-T-W-S-X heterotetramer), involved in the formation of a functional kinetochore outer plate, which is essential for kinetochore-microtubule attachment and faithful mitotic progression (PubMed:19620631). As a component of MHF and CENP-T-W-S-X complexes, binds DNA and bends it to form a nucleosome-like structure (PubMed:20347428, PubMed:22304917). DNA-binding function is fulfilled in the presence of CENPX, with the following preference for DNA substates: Holliday junction > double-stranded > splay arm > single-stranded. Does not bind DNA on its own (PubMed:20347428, PubMed:20347429).
Biological Process
See also
Diagram with PDB data
FANCM/CENPS/CENPXThe crystal structure of FANCM bound MHF complex