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IID00621
UniprotQ9BSM1
ProteinPolycomb group RING finger protein 1
GenePCGF1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
259
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 150-255 Hetero tetramer : IID00623Complex,Q8NHM5
 Evidence X-RAY 5jh5 C Reference
       Region 5jh5 C 150-156 disorder
       Region 5jh5 C 157-177 order
       Region 5jh5 C 178-188 disorder
       Region 5jh5 C 189-255 order
Seq 167-255 Hetero dimer : IID00623Complex
 Evidence X-RAY 4hpm B Reference
       Region 4hpm B 167-177 order
       Region 4hpm B 178-188 disorder
       Region 4hpm B 189-254 order
       Region 4hpm B 255-255 disorder
 Evidence X-RAY 4hpm D Reference
       Region 4hpm D 167-176 order
       Region 4hpm D 177-185 disorder
       Region 4hpm D 186-254 order
       Region 4hpm D 255-255 disorder
Seq 167-255 Hetero dimer : IID00087Complex
 Evidence X-RAY 4hpl B Reference
       Region 4hpl B 167-177 order
       Region 4hpl B 178-184 disorder
       Region 4hpl B 185-254 order
       Region 4hpl B 255-255 disorder
Seqphosphorylation
    3-3 Phosphoserine
Seqacetylation
    2-2 N-acetylalanine
 
Prediction
NeProc
Disorder 1-32,136-179,257-259
Order 33-135,180-256
ProS 12-23,146-179,257-259
AlphaFold
Disorder 1-8,12-12,19-32,133-158,178-185,256-259
Order 9-11,13-18,33-132,159-177,186-255
Pfam Hmmer
PF00097 47-85 2.2e-10
SEG 200-213
Function
Function in SwissProt
Component of the Polycomb group (PcG) multiprotein BCOR complex, a complex required to maintain the transcriptionally repressive state of some genes, such as BCL6 and the cyclin-dependent kinase inhibitor, CDKN1A. Transcriptional repressor that may be targeted to the DNA by BCL6; this transcription repressor activity may be related to PKC signaling pathway. Represses CDKN1A expression by binding to its promoter, and this repression is dependent on the retinoic acid response element (RARE element). Promotes cell cycle progression and enhances cell proliferation as well. May have a positive role in tumor cell growth by down-regulating CDKN1A. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:26151332). Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (PubMed:26151332). Regulates the expression of DPPA4 and NANOG in the NT2 embryonic carcinoma cells (PubMed:26687479).