Search Keyword:


Search option:


IID00622
 UniprotP15884
ProteinTranscription factor 4
GeneTCF4
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
667
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 11-27 Hetero dimer : IID00092Complex
 Evidence NMR 2kwf B Reference
       Region 2kwf B 11-27 order
       Region 2kwf B 11-11 high_rmsd
Seqphosphorylation
    66-66 Phosphoserine
    92-92 Phosphoserine
    87-87 Phosphoserine
    515-515 Phosphoserine
    372-372 Phosphoserine
 
Prediction
NeProc
Disorder 1-555,635-667
Order 556-634
ProS 8-37,58-61,68-78,102-133,177-197,212-219,224-228,323-333,355-360,375-403,415-422,488-500,519-548,553-555,660-667
AlphaFold
Disorder 1-15,17-17,23-24,27-320,332-381,405-552,627-667
Order 16-16,18-22,25-26,321-331,382-404,553-626
Pfam Hmmer
PF00010 565-618 2e-14
SEG 223-231 ,337-348 ,428-442 ,467-480 ,503-521 ,525-546
Function
Function in SwissProt
Transcription factor that binds to the immunoglobulin enhancer Mu-E5/KE5-motif. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Binds to the E-box present in the somatostatin receptor 2 initiator element (SSTR2-INR) to activate transcription (By similarity). Preferentially binds to either 5'-ACANNTGT-3' or 5'-CCANNTGG-3'.