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IID00622
 UniprotP15884
ProteinTranscription factor 4
GeneTCF4
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
667
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 11-27 Hetero dimer : IID00092Complex
 Evidence NMR 2kwf B 2kwf shows the HEB-PCET/KIX complex structure (PMID: 22972988). The residues 11-27 of TCF4 are identical to the residues 12-28 of TCF12 (HEB). Reference
       Region 2kwf B 11-27 order
       Region 2kwf B 11-11 high_rmsd
Seqdisorder 11-27
 Evidence NMR The residues 11-27 of TCF4 are identical to the residues 12-28 of TCF12(HEB). Reference
       Region 11-27 disorder
Seq 565-624 Homo octamer :
 Evidence X-RAY 6od3 J Reference
       Region 6od3 J 565-572 disorder
       Region 6od3 J 573-624 order
 Evidence X-RAY 6od3 I Reference
       Region 6od3 I 565-565 disorder
       Region 6od3 I 566-624 order
 Evidence X-RAY 6od3 H Reference
       Region 6od3 H 565-624 order
 Evidence X-RAY 6od3 G Reference
       Region 6od3 G 565-569 disorder
       Region 6od3 G 570-624 order
 Evidence X-RAY 6od3 F Reference
       Region 6od3 F 565-623 order
       Region 6od3 F 624-624 disorder
 Evidence X-RAY 6od3 E Reference
       Region 6od3 E 565-624 order
 Evidence X-RAY 6od3 B Reference
       Region 6od3 B 565-623 order
       Region 6od3 B 624-624 disorder
 Evidence X-RAY 6od3 A Reference
       Region 6od3 A 565-624 order
Seq 565-624 Homo tetramer :
 Evidence X-RAY 6od5 D Reference
       Region 6od5 D 565-624 order
 Evidence X-RAY 6od5 C Reference
       Region 6od5 C 565-623 order
       Region 6od5 C 624-624 disorder
 Evidence X-RAY 6od5 B Reference
       Region 6od5 B 565-623 order
       Region 6od5 B 624-624 disorder
 Evidence X-RAY 6od5 A Reference
       Region 6od5 A 565-624 order
Seq 565-624 Homo tetramer :
 Evidence X-RAY 6od4 H Reference
       Region 6od4 H 565-569 disorder
       Region 6od4 H 570-596 order
       Region 6od4 H 597-598 disorder
       Region 6od4 H 599-624 order
 Evidence X-RAY 6od4 G Reference
       Region 6od4 G 565-568 disorder
       Region 6od4 G 569-595 order
       Region 6od4 G 596-598 disorder
       Region 6od4 G 599-624 order
 Evidence X-RAY 6od4 B Reference
       Region 6od4 B 565-623 order
       Region 6od4 B 624-624 disorder
 Evidence X-RAY 6od4 A Reference
       Region 6od4 A 565-623 order
       Region 6od4 A 624-624 disorder
SeqProS verified 11-27 PCET motif Hetero dimer : IID00092Complex
       Region 2kwf B 11-27 order
       Region 11-27 disorder
Seqphosphorylation
    66-66 Phosphoserine
    92-92 Phosphoserine
    87-87 Phosphoserine
    515-515 Phosphoserine
    372-372 Phosphoserine
 
Prediction
NeProc
Disorder 1-555,635-667
Order 556-634
ProS 8-37,58-61,68-78,102-133,177-197,212-219,224-228,323-333,355-360,375-403,415-422,488-500,519-548,553-555,660-667
AlphaFold
Disorder 1-15,17-17,23-24,27-320,332-381,405-552,627-667
Order 16-16,18-22,25-26,321-331,382-404,553-626
Pfam Hmmer
PF00010 565-618 2e-14
SEG 223-231 ,337-348 ,428-442 ,467-480 ,503-521 ,525-546
Function
Function in SwissProt
Transcription factor that binds to the immunoglobulin enhancer Mu-E5/KE5-motif. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Binds to the E-box present in the somatostatin receptor 2 initiator element (SSTR2-INR) to activate transcription (By similarity). Preferentially binds to either 5'-ACANNTGT-3' or 5'-CCANNTGG-3'.
Biological Process
Diagram with PDB data
TCF4/CREBBPThe structure of E-protein activation domain 1 bound to the KIX domain of CBP/p300 elucidates leukemia induction by E2A-PBX1