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IID00625
 UniprotP25025
ProteinC-X-C chemokine receptor type 2
GeneCXCR2
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
360
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 356-360 Monomer : IID00134Complex
 Evidence X-RAY 4q3h A Reference
       Region 4q3h A 356-360 order
Seq 356-360 Homo dimer : O15085
 Evidence X-RAY 5tyt C Reference
       Region 5tyt C 356-360 order
 Evidence X-RAY 5tyt D Reference
       Region 5tyt D 356-360 order
Seq 356-360 Homo dimer : O15085
 Evidence X-RAY 5tyt A Reference
       Region 5tyt A 356-360 order
 Evidence X-RAY 5tyt B Reference
       Region 5tyt B 356-360 order
Seq 356-360 Monomer : IID00134Complex
 Evidence X-RAY 4q3h B Reference
       Region 4q3h B 356-360 order
Seqphosphorylation
    347-347 Phosphoserine
    352-352 Phosphoserine
    351-351 Phosphoserine
    353-353 Phosphoserine
 
Prediction
NeProc
Disorder 1-7,156-160,331-360
Order 8-155,161-330
ProS 1-7,156-160,331-360
AlphaFold
Disorder 1-38,40-46,154-157,200-205,208-209,242-247,339-360
Order 39-39,47-153,158-199,206-207,210-241,248-338
Pfam Hmmer
PF00001 65-314 1.4e-89
SEG 57-72 ,87-101 ,167-182
Function
Function in SwissProt
Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2.