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IID00626
 UniprotP48431
ProteinTranscription factor SOX-2
GeneSOX2
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
317
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 39-118 Monomer :
 Evidence NMR 2le4 A C terminus of the Sox2-HMG domain is described to be disordered in the free state (PubMed=12923055). Reference
       Region 2le4 A 39-104 order
       Region 2le4 A 39-42 high_rmsd
       Region 2le4 A 105-118 disorder
       Region 2le4 A 105-118 high_rmsd
Seq 39-121 Hetero dimer : IID00144Complex
 Evidence NMR 1o4x B Reference
       Region 1o4x B 39-115 order
       Region 1o4x B 116-121 disorder
SeqProS verified 105-115 This region is ordered when it binds upon DNA. Hetero dimer : IID00144Complex
       Region 1o4x B 39-115 order
       Region 2le4 A 105-118 disorder
Seqphosphorylation
    251-251 Phosphoserine
 
Prediction
NeProc
Disorder 1-44,108-317
Order 45-107
ProS 1-10,37-44,108-112,153-166,198-201,267-280,310-317
AlphaFold
Disorder 1-38,119-271,275-317
Order 39-118,272-274
Pfam Hmmer
PF00505 41-109 1.1e-34
SEG 12-33 ,135-154 ,246-261
Function
Function in SwissProt
Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity). Binds to the proximal enhancer region of NANOG (By similarity). Critical for early embryogenesis and for embryonic stem cell pluripotency (PubMed:18035408). Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity). May function as a switch in neuronal development (By similarity).
Biological Process
Diagram with PDB data
SOX2/POU2F1/DNATERNARY COMPLEX OF THE DNA BINDING DOMAINS OF THE OCT1 AND SOX2 TRANSCRIPTION FACTORS WITH A 19MER OLIGONUCLEOTIDE FROM THE HOXB1 REGULATORY ELEMENT
SOX2/KPNA4SOX2 bound to Importin-alpha 3