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IID00630
 UniprotQ9UKT5
ProteinF-box only protein 4
GeneFBXO4
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
387
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 55-149,171-387 Hetero dimer : P63208
 Evidence X-RAY 3l2o B Reference
       Region 3l2o B 55-131 order
       Region 3l2o B 132-135 disorder
       Region 3l2o B 136-149 order
       Region 3l2o B 171-241 order
       Region 3l2o B 242-271 disorder
       Region 3l2o B 272-383 order
       Region 3l2o B 384-387 disorder
Seq 162-387 Hetero dimer : IID00155Complex
 Evidence X-RAY 3l82 B Reference
       Region 3l82 B 162-163 disorder
       Region 3l82 B 164-239 order
       Region 3l82 B 240-276 disorder
       Region 3l82 B 277-384 order
       Region 3l82 B 385-387 disorder
Seqphosphorylation
    12-12 Phosphoserine
    48-48 Phosphoserine
 
Prediction
NeProc
Disorder 1-54,248-252,264-267,384-387
Order 55-247,253-263,268-383
ProS 19-41,264-267
AlphaFold
Disorder 1-56,124-136,151-174,251-255,262-271,385-387
Order 57-123,137-150,175-250,256-261,272-384
Pfam Hmmer
PF00646 57-104 7.2e-11
SEG 192-203 ,348-355
Function
Function in SwissProt
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes ubiquitination of CCND1 and its subsequent proteasomal degradation. Recognizes TERF1 and promotes its ubiquitination together with UBE2D1.