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IID00632
 UniprotQ9Y5L0
ProteinTransportin-3
GeneTNPO3
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
923
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-923 Hetero dimer : IID00162Complex
 Evidence X-RAY 4c0q A Reference
       Region 4c0q A 1-4 disorder
       Region 4c0q A 5-189 order
       Region 4c0q A 190-194 disorder
       Region 4c0q A 195-353 order
       Region 4c0q A 354-362 disorder
       Region 4c0q A 363-595 order
       Region 4c0q A 596-606 disorder
       Region 4c0q A 607-624 order
       Region 4c0q A 625-633 disorder
       Region 4c0q A 634-671 order
       Region 4c0q A 672-676 disorder
       Region 4c0q A 677-880 order
       Region 4c0q A 881-888 disorder
       Region 4c0q A 889-922 order
       Region 4c0q A 923-923 disorder
 Evidence X-RAY 4c0q B Reference
       Region 4c0q B 1-4 disorder
       Region 4c0q B 5-54 order
       Region 4c0q B 55-56 disorder
       Region 4c0q B 57-158 order
       Region 4c0q B 159-165 disorder
       Region 4c0q B 166-187 order
       Region 4c0q B 188-195 disorder
       Region 4c0q B 196-355 order
       Region 4c0q B 356-358 disorder
       Region 4c0q B 359-447 order
       Region 4c0q B 448-457 disorder
       Region 4c0q B 458-488 order
       Region 4c0q B 489-494 disorder
       Region 4c0q B 495-526 order
       Region 4c0q B 527-551 disorder
       Region 4c0q B 552-560 order
       Region 4c0q B 561-580 disorder
       Region 4c0q B 581-594 order
       Region 4c0q B 595-606 disorder
       Region 4c0q B 607-621 order
       Region 4c0q B 622-641 disorder
       Region 4c0q B 642-671 order
       Region 4c0q B 672-682 disorder
       Region 4c0q B 683-705 order
       Region 4c0q B 706-721 disorder
       Region 4c0q B 722-765 order
       Region 4c0q B 766-771 disorder
       Region 4c0q B 772-810 order
       Region 4c0q B 811-818 disorder
       Region 4c0q B 819-877 order
       Region 4c0q B 878-892 disorder
       Region 4c0q B 893-922 order
       Region 4c0q B 923-923 disorder
 Evidence X-RAY 4ol0 B Reference
       Region 4ol0 B 3-3 disorder
       Region 4ol0 B 4-215 order
       Region 4ol0 B 216-220 disorder
       Region 4ol0 B 221-597 order
       Region 4ol0 B 598-605 disorder
       Region 4ol0 B 606-883 order
       Region 4ol0 B 884-888 disorder
       Region 4ol0 B 889-923 order
Seq 1-923 Hetero dimer : Q07955
 Evidence X-RAY 4c0o A Reference
       Region 4c0o A 1-2 disorder
       Region 4c0o A 3-598 order
       Region 4c0o A 599-604 disorder
       Region 4c0o A 605-626 order
       Region 4c0o A 627-631 disorder
       Region 4c0o A 632-880 order
       Region 4c0o A 881-888 disorder
       Region 4c0o A 889-922 order
       Region 4c0o A 923-923 disorder
 Evidence X-RAY 4c0o B Reference
       Region 4c0o B 1-2 disorder
       Region 4c0o B 3-189 order
       Region 4c0o B 190-192 disorder
       Region 4c0o B 193-598 order
       Region 4c0o B 599-604 disorder
       Region 4c0o B 605-626 order
       Region 4c0o B 627-631 disorder
       Region 4c0o B 632-880 order
       Region 4c0o B 881-888 disorder
       Region 4c0o B 889-922 order
       Region 4c0o B 923-923 disorder
Seq 1-923 Monomer :
 Evidence X-RAY 4c0p A Reference
       Region 4c0p A 1-2 disorder
       Region 4c0p A 3-189 order
       Region 4c0p A 190-194 disorder
       Region 4c0p A 195-429 order
       Region 4c0p A 430-431 disorder
       Region 4c0p A 432-595 order
       Region 4c0p A 596-606 disorder
       Region 4c0p A 607-626 order
       Region 4c0p A 627-631 disorder
       Region 4c0p A 632-880 order
       Region 4c0p A 881-888 disorder
       Region 4c0p A 889-922 order
       Region 4c0p A 923-923 disorder
 Evidence X-RAY 4c0p B Reference
       Region 4c0p B 1-2 disorder
       Region 4c0p B 3-189 order
       Region 4c0p B 190-194 disorder
       Region 4c0p B 195-429 order
       Region 4c0p B 430-431 disorder
       Region 4c0p B 432-595 order
       Region 4c0p B 596-606 disorder
       Region 4c0p B 607-626 order
       Region 4c0p B 627-631 disorder
       Region 4c0p B 632-880 order
       Region 4c0p B 881-888 disorder
       Region 4c0p B 889-922 order
       Region 4c0p B 923-923 disorder
 Evidence X-RAY 4c0p C Reference
       Region 4c0p C 1-2 disorder
       Region 4c0p C 3-189 order
       Region 4c0p C 190-194 disorder
       Region 4c0p C 195-429 order
       Region 4c0p C 430-431 disorder
       Region 4c0p C 432-595 order
       Region 4c0p C 596-606 disorder
       Region 4c0p C 607-626 order
       Region 4c0p C 627-631 disorder
       Region 4c0p C 632-880 order
       Region 4c0p C 881-888 disorder
       Region 4c0p C 889-922 order
       Region 4c0p C 923-923 disorder
 Evidence X-RAY 4c0p D Reference
       Region 4c0p D 1-2 disorder
       Region 4c0p D 3-189 order
       Region 4c0p D 190-194 disorder
       Region 4c0p D 195-429 order
       Region 4c0p D 430-431 disorder
       Region 4c0p D 432-595 order
       Region 4c0p D 596-606 disorder
       Region 4c0p D 607-626 order
       Region 4c0p D 627-631 disorder
       Region 4c0p D 632-881 order
       Region 4c0p D 882-888 disorder
       Region 4c0p D 889-922 order
       Region 4c0p D 923-923 disorder
Seqphosphorylation
    74-74 Phosphoserine
    896-896 Phosphothreonine
Seqacetylation
    1-1 N-acetylmethionine
 
Prediction
NeProc
Disorder 1-6
Order 7-599,605-923
AlphaFold
Disorder 1-3,600-605
Order 4-599,606-923
Pfam Hmmer
PF08389 101-249 4.5e-43
SEG 108-117 ,318-328
Function
Function in SwissProt
Importin, which transports target proteins into the nucleus (PubMed:10366588, PubMed:10713112, PubMed:11517331, PubMed:12628928, PubMed:24449914). Specifically mediates the nuclear import of splicing factor serine/arginine (SR) proteins, such as RBM4, SFRS1 and SFRS2, by recognizing phosphorylated SR domains (PubMed:10366588, PubMed:10713112, PubMed:11517331, PubMed:12628928, PubMed:24449914). Also mediates the nuclear import of serine/arginine (SR) protein CPSF6, independently of CPSF6 phosphorylation (PubMed:30916345, PubMed:31465518). The nuclear import process is regulated by the small GTPase Ran that partitions between cytoplasm and nucleus in the predominantly GDP- and GTP-bound form, respectively (PubMed:23878195, PubMed:24449914). Importin associates with target cargo proteins in the cytoplasm, and the competitive binding of GTP-bound Ran induces the release of cargos in the nucleus (PubMed:23878195, PubMed:24449914).
(Microbial infection) Involved in immunodeficiency virus (HIV-1) infection by importing the pre-integration complex (PIC) into the nucleus (PubMed:18722123, PubMed:21901095, PubMed:22398280, PubMed:29329553). Required for a nuclear maturation step of HIV-1 prior to integration (PubMed:21901095, PubMed:22398280).