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IID00633
 UniprotP51965
ProteinUbiquitin-conjugating enzyme E2 E1
GeneUBE2E1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
193
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-193 Homo dimer :
 Evidence X-RAY 3bzh A Reference
       Region 3bzh A 1-20 disorder
       Region 3bzh A 21-27 order
       Region 3bzh A 28-39 disorder
       Region 3bzh A 40-193 order
Seq 5-14 Hetero dimer : IID00176Complex
 Evidence X-RAY 4jjq B Reference
       Region 4jjq B 5-7 disorder
       Region 4jjq B 8-11 order
       Region 4jjq B 12-14 disorder
Seq 37-193 Monomer :
 Evidence X-RAY 5lbn A Reference
       Region 5lbn A 37-39 disorder
       Region 5lbn A 40-193 order
Seq 83-91 Hetero trimer : P30464
 Evidence X-RAY 1xr9 C Reference
       Region 1xr9 C 83-91 order
SeqProS verified 8-11 Hetero dimer : IID00176Complex
       Region 4jjq B 8-11 order
       Region 3bzh A 1-20 disorder
Seqacetylation
    2-2 N-acetylserine
 
Prediction
NeProc
Disorder 1-49
Order 50-193
AlphaFold
Disorder 1-43
Order 44-193
Pfam Hmmer
PF00179 51-188 4.7e-76
SEG 2-18 ,22-35
Function
Function in SwissProt
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes the covalent attachment of ISG15 to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. In vitro also catalyzes 'Lys-48'-linked polyubiquitination.