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IID00636
 UniprotQ9NR09
ProteinBaculoviral IAP repeat-containing protein 6
GeneBIRC6
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 xml
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
4857
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 4498-4820 Monomer :
 Evidence X-RAY 3ceg A Reference
       Region 3ceg A 4498-4520 disorder
       Region 3ceg A 4521-4780 order
       Region 3ceg A 4781-4786 disorder
       Region 3ceg A 4787-4818 order
       Region 3ceg A 4819-4820 disorder
 Evidence X-RAY 3ceg B Reference
       Region 3ceg B 4498-4522 disorder
       Region 3ceg B 4523-4566 order
       Region 3ceg B 4567-4567 disorder
       Region 3ceg B 4568-4780 order
       Region 3ceg B 4781-4782 disorder
       Region 3ceg B 4783-4783 order
       Region 3ceg B 4784-4784 disorder
       Region 3ceg B 4785-4818 order
       Region 3ceg B 4819-4820 disorder
Seqphosphorylation
    473-473 Phosphoserine
    480-480 Phosphoserine
    482-482 Phosphoserine
    581-581 Phosphoserine
    590-590 Phosphoserine
    1710-1710 Phosphothreonine
    2222-2222 Phosphoserine
    2955-2955 Phosphoserine
    3931-3931 Phosphothreonine
    4023-4023 Phosphoserine
 
Prediction
NeProc
Disorder 1-52,465-711,756-812,871-896,971-1005,1135-1164,1235-1285,1514-1524,1588-1609,1669-1767,2151-2197,2209-2227,2263-2319,2423-2537,2545-2555,2601-2633,2673-2680,2735-2742,2936-2976,3011-3012,3118-3154,3159-3163,3170-3177,3234-3253,3471-3479,3570-3598,3649-3678,3722-3753,3794-3801,3882-3956,4015-4077,4096-4150,4259-4302,4345-4350,4418-4433,4441-4522,4565-4567,4782-4793,4804-4857
Order 53-153,158-316,323-440,444-464,712-755,813-870,897-970,1006-1051,1057-1134,1165-1229,1286-1339,1348-1513,1530-1586,1610-1668,1768-1902,1907-2002,2011-2150,2198-2208,2228-2262,2320-2422,2538-2544,2556-2600,2634-2672,2681-2734,2743-2935,2977-3003,3013-3117,3155-3158,3164-3169,3178-3233,3254-3306,3312-3423,3430-3470,3480-3569,3599-3648,3679-3721,3754-3793,3802-3837,3843-3881,3957-4010,4078-4095,4155-4196,4207-4258,4303-4340,4351-4417,4434-4440,4523-4564,4572-4781,4794-4803
ProS 1-5,10-25,465-469,474-489,501-534,544-555,560-577,594-613,622-638,644-667,676-702,767-801,809-812,871-871,971-979,1135-1164,1235-1243,1253-1268,1520-1524,1588-1592,1599-1602,1670-1675,1683-1690,1697-1728,1750-1757,2151-2151,2158-2197,2209-2216,2223-2227,2285-2289,2461-2469,2481-2495,2518-2537,2545-2555,2953-2968,3011-3012,3125-3141,3159-3163,3170-3177,3234-3253,3471-3475,3581-3598,3660-3664,3894-3930,3941-3945,4028-4035,4059-4077,4116-4137,4259-4263,4285-4302,4433-4433,4441-4462,4470-4498,4517-4522,4782-4788,4804-4822,4849-4857
Pfam Hmmer
PF00653 289-359 4.4e-34
PF00179 4577-4735 1.9e-43
SEG 2-14 ,24-53 ,469-490 ,621-632 ,671-682 ,766-778 ,1050-1067 ,1605-1621 ,1627-1655 ,1660-1668 ,1695-1712 ,1979-1984 ,2030-2038 ,2128-2154 ,2212-2228 ,2239-2252 ,2383-2387 ,2444-2457 ,2477-2491 ,2657-2673 ,2944-2956 ,3580-3597 ,3638-3662 ,3733-3755 ,3886-3905 ,3926-3944 ,4131-4142 ,4292-4303 ,4418-4428 ,4565-4579 ,4584-4596 ,4686-4701
Function
Function in SwissProt
Anti-apoptotic protein which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase. Has an unusual ubiquitin conjugation system in that it could combine in a single polypeptide, ubiquitin conjugating (E2) with ubiquitin ligase (E3) activity, forming a chimeric E2/E3 ubiquitin ligase. Its tragets include CASP9 and DIABLO/SMAC. Acts as an inhibitor of CASP3, CASP7 and CASP9. Important regulator for the final stages of cytokinesis. Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification.