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IID00637
 UniprotP62256
ProteinUbiquitin-conjugating enzyme E2 H
GeneUBE2H
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 xml
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
183
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-160 Homo dimer :
 Evidence X-RAY 2z5d B Reference
       Region 2z5d B 1-5 disorder
       Region 2z5d B 6-156 order
       Region 2z5d B 157-160 disorder
 Evidence X-RAY 2z5d A Reference
       Region 2z5d A 1-3 disorder
       Region 2z5d A 4-155 order
       Region 2z5d A 156-160 disorder
Seqacetylation
    60-60 N6-acetyllysine
 
Prediction
NeProc
Disorder 1-11,152-183
Order 12-151
ProS 8-11,152-155,177-183
AlphaFold
Disorder 1-1,160-183
Order 2-159
Pfam Hmmer
PF00179 10-145 5.8e-56
SEG 135-148 ,163-177
Function
Function in SwissProt
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins (PubMed:8132613, PubMed:17588522, PubMed:20061386). E2 ubiquitin conjugating enzyme that transfers ubiquitin to MAEA, a core component of the CTLH E3 ubiquitin-protein ligase complex (PubMed:29911972). In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination (PubMed:20061386). Capable, in vitro, to ubiquitinate histone H2A (PubMed:8132613).