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IID00642
 UniprotO60216
ProteinDouble-strand-break repair protein rad21 homolog
GeneRAD21
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
631
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 281-420 Hetero dimer : IID00674Complex
 Evidence X-RAY 4pju B Reference
       Region 4pju B 281-320 disorder
       Region 4pju B 321-394 order
       Region 4pju B 395-420 disorder
 Evidence X-RAY 4pjw B Reference
       Region 4pjw B 281-320 disorder
       Region 4pjw B 321-395 order
       Region 4pjw B 396-420 disorder
 Evidence X-RAY 4pk7 B Reference
       Region 4pk7 B 281-320 disorder
       Region 4pk7 B 321-396 order
       Region 4pk7 B 397-420 disorder
Seqphosphorylation
    46-46 Phosphoserine
    153-153 Phosphoserine
    175-175 Phosphoserine
    623-623 Phosphothreonine
    545-545 Phosphoserine
    454-454 Phosphoserine
    394-394 Phosphothreonine
    249-249 Phosphoserine
 
Prediction
NeProc
Disorder 143-323,404-559
Order 1-142,324-403,560-631
ProS 143-178,208-224,242-246,262-267,289-308,404-430,440-452,460-466,474-492,511-525,550-559
AlphaFold
Disorder 1-11,90-105,107-138,140-321,396-553,555-556,631-631
Order 12-89,106-106,139-139,322-395,554-554,557-630
Pfam Hmmer
PF04825 1-111 1.1e-68
PF04824 574-628 2.6e-28
SEG 271-288 ,430-436 ,485-510 ,517-543
Function
Function in SwissProt
Double-strand-break repair protein rad21 homolog:As a member of the cohesin complex, involved in sister chromatid cohesion from the time of DNA replication in S phase to their segregation in mitosis, a function that is essential for proper chromosome segregation, post-replicative DNA repair, and the prevention of inappropriate recombination between repetitive regions (PubMed:11509732). The cohesin complex may also play a role in spindle pole assembly during mitosis (PubMed:11590136). In interphase, cohesins may function in the control of gene expression by binding to numerous sites within the genome (By similarity). May control RUNX1 gene expression (Probable). Binds to and represses APOB gene promoter (PubMed:25575569). May play a role in embryonic gut development, possibly through the regulation of enteric neuron development (By similarity).
64-kDa C-terminal product:May promote apoptosis.