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IID00643
 UniprotO60502
ProteinProtein O-GlcNAcase
GeneOGA
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
916
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-916 Homo dimer :
 Evidence X-RAY 5m7s B Reference
       Region 5m7s B 1-58 disorder
       Region 5m7s B 59-340 order
       Region 5m7s B 341-371 disorder
       Region 5m7s B 372-395 order
       Region 5m7s B 396-537 disorder
       Region 5m7s B 538-593 order
       Region 5m7s B 594-600 disorder
       Region 5m7s B 601-664 order
       Region 5m7s B 665-677 disorder
       Region 5m7s B 678-695 order
       Region 5m7s B 696-916 disorder
 Evidence X-RAY 5m7s A Reference
       Region 5m7s A 1-57 disorder
       Region 5m7s A 58-337 order
       Region 5m7s A 338-371 disorder
       Region 5m7s A 372-395 order
       Region 5m7s A 396-536 disorder
       Region 5m7s A 537-593 order
       Region 5m7s A 594-600 disorder
       Region 5m7s A 601-663 order
       Region 5m7s A 664-676 disorder
       Region 5m7s A 677-695 order
       Region 5m7s A 696-916 disorder
 Evidence X-RAY 5m7r B Reference
       Region 5m7r B 1-58 disorder
       Region 5m7r B 59-340 order
       Region 5m7r B 341-370 disorder
       Region 5m7r B 371-395 order
       Region 5m7r B 396-536 disorder
       Region 5m7r B 537-596 order
       Region 5m7r B 597-599 disorder
       Region 5m7r B 600-672 order
       Region 5m7r B 673-674 disorder
       Region 5m7r B 675-695 order
       Region 5m7r B 696-706 disorder
       Region 5m7r B 707-715 order
       Region 5m7r B 716-916 disorder
 Evidence X-RAY 5m7r A Reference
       Region 5m7r A 1-58 disorder
       Region 5m7r A 59-337 order
       Region 5m7r A 338-370 disorder
       Region 5m7r A 371-395 order
       Region 5m7r A 396-536 disorder
       Region 5m7r A 537-595 order
       Region 5m7r A 596-598 disorder
       Region 5m7r A 599-673 order
       Region 5m7r A 674-675 disorder
       Region 5m7r A 676-695 order
       Region 5m7r A 696-707 disorder
       Region 5m7r A 708-715 order
       Region 5m7r A 716-916 disorder
 Evidence X-RAY 5m7u B Reference
       Region 5m7u B 1-58 disorder
       Region 5m7u B 59-339 order
       Region 5m7u B 340-370 disorder
       Region 5m7u B 371-395 order
       Region 5m7u B 396-536 disorder
       Region 5m7u B 537-593 order
       Region 5m7u B 594-600 disorder
       Region 5m7u B 601-664 order
       Region 5m7u B 665-674 disorder
       Region 5m7u B 675-695 order
       Region 5m7u B 696-916 disorder
 Evidence X-RAY 5m7u A Reference
       Region 5m7u A 1-58 disorder
       Region 5m7u A 59-337 order
       Region 5m7u A 338-370 disorder
       Region 5m7u A 371-395 order
       Region 5m7u A 396-536 disorder
       Region 5m7u A 537-593 order
       Region 5m7u A 594-600 disorder
       Region 5m7u A 601-663 order
       Region 5m7u A 664-671 disorder
       Region 5m7u A 672-695 order
       Region 5m7u A 696-916 disorder
 Evidence X-RAY 5m7t B Reference
       Region 5m7t B 1-58 disorder
       Region 5m7t B 59-340 order
       Region 5m7t B 341-370 disorder
       Region 5m7t B 371-395 order
       Region 5m7t B 396-536 disorder
       Region 5m7t B 537-592 order
       Region 5m7t B 593-599 disorder
       Region 5m7t B 600-664 order
       Region 5m7t B 665-676 disorder
       Region 5m7t B 677-695 order
       Region 5m7t B 696-916 disorder
 Evidence X-RAY 5m7t A Reference
       Region 5m7t A 1-58 disorder
       Region 5m7t A 59-337 order
       Region 5m7t A 338-370 disorder
       Region 5m7t A 371-395 order
       Region 5m7t A 396-536 disorder
       Region 5m7t A 537-594 order
       Region 5m7t A 595-598 disorder
       Region 5m7t A 599-667 order
       Region 5m7t A 668-675 disorder
       Region 5m7t A 676-695 order
       Region 5m7t A 696-916 disorder
Seq 14-400,544-705 Hetero tetramer :
 Evidence X-RAY 5uhp G Reference
       Region 5uhp G 554-588 order
       Region 5uhp G 589-598 disorder
       Region 5uhp G 599-660 order
       Region 5uhp G 661-678 disorder
       Region 5uhp G 679-695 order
       Region 5uhp G 696-705 disorder
 Evidence X-RAY 5uhp F Reference
       Region 5uhp F 554-589 order
       Region 5uhp F 590-601 disorder
       Region 5uhp F 602-660 order
       Region 5uhp F 661-681 disorder
       Region 5uhp F 682-695 order
       Region 5uhp F 696-705 disorder
 Evidence X-RAY 5uho D Reference
       Region 5uho D 544-589 order
       Region 5uho D 590-603 disorder
       Region 5uho D 604-663 order
       Region 5uho D 664-681 disorder
       Region 5uho D 682-694 order
       Region 5uho D 695-705 disorder
 Evidence X-RAY 5uho B Reference
       Region 5uho B 544-590 order
       Region 5uho B 591-605 disorder
       Region 5uho B 606-664 order
       Region 5uho B 665-681 disorder
       Region 5uho B 682-694 order
       Region 5uho B 695-705 disorder
 Evidence X-RAY 5uhk D Reference
       Region 5uhk D 544-589 order
       Region 5uhk D 590-603 disorder
       Region 5uhk D 604-663 order
       Region 5uhk D 664-681 disorder
       Region 5uhk D 682-694 order
       Region 5uhk D 695-705 disorder
 Evidence X-RAY 5uhk B Reference
       Region 5uhk B 544-590 order
       Region 5uhk B 591-605 disorder
       Region 5uhk B 606-664 order
       Region 5uhk B 665-681 disorder
       Region 5uhk B 682-694 order
       Region 5uhk B 695-705 disorder
 Evidence X-RAY 5uhp B Reference
       Region 5uhp B 14-58 disorder
       Region 5uhp B 59-176 order
       Region 5uhp B 177-178 disorder
       Region 5uhp B 179-340 order
       Region 5uhp B 341-370 disorder
       Region 5uhp B 371-397 order
       Region 5uhp B 398-400 disorder
 Evidence X-RAY 5uhp A Reference
       Region 5uhp A 14-58 disorder
       Region 5uhp A 59-176 order
       Region 5uhp A 177-178 disorder
       Region 5uhp A 179-340 order
       Region 5uhp A 341-370 disorder
       Region 5uhp A 371-397 order
       Region 5uhp A 398-400 disorder
 Evidence X-RAY 5uho C Reference
       Region 5uho C 56-57 disorder
       Region 5uho C 58-338 order
       Region 5uho C 339-371 disorder
       Region 5uho C 372-392 order
       Region 5uho C 393-400 disorder
 Evidence X-RAY 5uho A Reference
       Region 5uho A 56-57 disorder
       Region 5uho A 58-340 order
       Region 5uho A 341-371 disorder
       Region 5uho A 372-392 order
       Region 5uho A 393-400 disorder
 Evidence X-RAY 5uhk C Reference
       Region 5uhk C 56-57 disorder
       Region 5uhk C 58-338 order
       Region 5uhk C 339-371 disorder
       Region 5uhk C 372-392 order
       Region 5uhk C 393-400 disorder
 Evidence X-RAY 5uhk A Reference
       Region 5uhk A 56-57 disorder
       Region 5uhk A 58-340 order
       Region 5uhk A 341-371 disorder
       Region 5uhk A 372-392 order
       Region 5uhk A 393-400 disorder
Seq 14-400,544-705 Hetero tetramer :
 Evidence X-RAY 5uhp H Reference
       Region 5uhp H 554-587 order
       Region 5uhp H 588-600 disorder
       Region 5uhp H 601-660 order
       Region 5uhp H 661-675 disorder
       Region 5uhp H 676-693 order
       Region 5uhp H 694-705 disorder
 Evidence X-RAY 5uhp E Reference
       Region 5uhp E 554-589 order
       Region 5uhp E 590-600 disorder
       Region 5uhp E 601-659 order
       Region 5uhp E 660-676 disorder
       Region 5uhp E 677-693 order
       Region 5uhp E 694-705 disorder
 Evidence X-RAY 5uhl D Reference
       Region 5uhl D 544-589 order
       Region 5uhl D 590-603 disorder
       Region 5uhl D 604-663 order
       Region 5uhl D 664-681 disorder
       Region 5uhl D 682-694 order
       Region 5uhl D 695-705 disorder
 Evidence X-RAY 5uhl B Reference
       Region 5uhl B 544-590 order
       Region 5uhl B 591-605 disorder
       Region 5uhl B 606-664 order
       Region 5uhl B 665-681 disorder
       Region 5uhl B 682-694 order
       Region 5uhl B 695-705 disorder
 Evidence X-RAY 5uhp D Reference
       Region 5uhp D 14-49 disorder
       Region 5uhp D 50-174 order
       Region 5uhp D 175-178 disorder
       Region 5uhp D 179-340 order
       Region 5uhp D 341-369 disorder
       Region 5uhp D 370-392 order
       Region 5uhp D 393-400 disorder
 Evidence X-RAY 5uhp C Reference
       Region 5uhp C 14-48 disorder
       Region 5uhp C 49-174 order
       Region 5uhp C 175-179 disorder
       Region 5uhp C 180-340 order
       Region 5uhp C 341-369 disorder
       Region 5uhp C 370-392 order
       Region 5uhp C 393-400 disorder
 Evidence X-RAY 5uhl C Reference
       Region 5uhl C 56-57 disorder
       Region 5uhl C 58-338 order
       Region 5uhl C 339-371 disorder
       Region 5uhl C 372-392 order
       Region 5uhl C 393-400 disorder
 Evidence X-RAY 5uhl A Reference
       Region 5uhl A 56-57 disorder
       Region 5uhl A 58-340 order
       Region 5uhl A 341-371 disorder
       Region 5uhl A 372-392 order
       Region 5uhl A 393-400 disorder
Seq 60-400,553-704 Hetero tetramer : P20700
 Evidence X-RAY 5vvx C Reference
       Region 5vvx C 60-336 order
       Region 5vvx C 337-372 disorder
       Region 5vvx C 373-391 order
       Region 5vvx C 392-400 disorder
       Region 5vvx C 553-592 order
       Region 5vvx C 593-601 disorder
       Region 5vvx C 602-694 order
       Region 5vvx C 695-704 disorder
 Evidence X-RAY 5vvx A Reference
       Region 5vvx A 60-333 order
       Region 5vvx A 334-373 disorder
       Region 5vvx A 374-399 order
       Region 5vvx A 400-400 disorder
       Region 5vvx A 553-592 order
       Region 5vvx A 593-602 disorder
       Region 5vvx A 603-662 order
       Region 5vvx A 663-678 disorder
       Region 5vvx A 679-696 order
       Region 5vvx A 697-704 disorder
Seq 60-400,553-704 Hetero tetramer : Q15750
 Evidence X-RAY 5vvu C Reference
       Region 5vvu C 60-336 order
       Region 5vvu C 337-372 disorder
       Region 5vvu C 373-391 order
       Region 5vvu C 392-400 disorder
       Region 5vvu C 553-592 order
       Region 5vvu C 593-603 disorder
       Region 5vvu C 604-694 order
       Region 5vvu C 695-704 disorder
 Evidence X-RAY 5vvu A Reference
       Region 5vvu A 60-333 order
       Region 5vvu A 334-373 disorder
       Region 5vvu A 374-398 order
       Region 5vvu A 399-400 disorder
       Region 5vvu A 553-592 order
       Region 5vvu A 593-603 disorder
       Region 5vvu A 604-665 order
       Region 5vvu A 666-678 disorder
       Region 5vvu A 679-700 order
       Region 5vvu A 701-704 disorder
Seq 60-400,553-704 Hetero tetramer : P02511
 Evidence X-RAY 5vvv C Reference
       Region 5vvv C 60-335 order
       Region 5vvv C 336-372 disorder
       Region 5vvv C 373-391 order
       Region 5vvv C 392-400 disorder
       Region 5vvv C 553-590 order
       Region 5vvv C 591-603 disorder
       Region 5vvv C 604-673 order
       Region 5vvv C 674-676 disorder
       Region 5vvv C 677-694 order
       Region 5vvv C 695-704 disorder
 Evidence X-RAY 5vvv A Reference
       Region 5vvv A 60-333 order
       Region 5vvv A 334-373 disorder
       Region 5vvv A 374-398 order
       Region 5vvv A 399-400 disorder
       Region 5vvv A 553-592 order
       Region 5vvv A 593-603 disorder
       Region 5vvv A 604-661 order
       Region 5vvv A 662-678 disorder
       Region 5vvv A 679-696 order
       Region 5vvv A 697-704 disorder
Seq 60-400,553-704 Homo dimer :
 Evidence X-RAY 5vvo A Reference
       Region 5vvo A 60-334 order
       Region 5vvo A 335-372 disorder
       Region 5vvo A 373-400 order
       Region 5vvo A 553-662 order
       Region 5vvo A 663-679 disorder
       Region 5vvo A 680-701 order
       Region 5vvo A 702-704 disorder
 Evidence X-RAY 5vvo B Reference
       Region 5vvo B 60-333 order
       Region 5vvo B 334-373 disorder
       Region 5vvo B 374-392 order
       Region 5vvo B 393-400 disorder
       Region 5vvo B 553-592 order
       Region 5vvo B 593-601 disorder
       Region 5vvo B 602-695 order
       Region 5vvo B 696-704 disorder
Seq 60-400,553-704 Homo dimer :
 Evidence X-RAY 5un9 A Reference
       Region 5un9 A 60-333 order
       Region 5un9 A 334-373 disorder
       Region 5un9 A 374-398 order
       Region 5un9 A 399-400 disorder
       Region 5un9 A 553-591 order
       Region 5un9 A 592-603 disorder
       Region 5un9 A 604-662 order
       Region 5un9 A 663-681 disorder
       Region 5un9 A 682-700 order
       Region 5un9 A 701-704 disorder
 Evidence X-RAY 5un9 B Reference
       Region 5un9 B 60-333 order
       Region 5un9 B 334-373 disorder
       Region 5un9 B 374-392 order
       Region 5un9 B 393-400 disorder
       Region 5un9 B 553-592 order
       Region 5un9 B 593-602 disorder
       Region 5un9 B 603-693 order
       Region 5un9 B 694-704 disorder
Seq 60-400,553-704 Hetero tetramer : IID00146Complex
 Evidence X-RAY 5vvt C Reference
       Region 5vvt C 60-336 order
       Region 5vvt C 337-372 disorder
       Region 5vvt C 373-391 order
       Region 5vvt C 392-400 disorder
       Region 5vvt C 553-591 order
       Region 5vvt C 592-604 disorder
       Region 5vvt C 605-671 order
       Region 5vvt C 672-675 disorder
       Region 5vvt C 676-694 order
       Region 5vvt C 695-704 disorder
 Evidence X-RAY 5vvt A Reference
       Region 5vvt A 60-333 order
       Region 5vvt A 334-373 disorder
       Region 5vvt A 374-398 order
       Region 5vvt A 399-400 disorder
       Region 5vvt A 553-589 order
       Region 5vvt A 590-603 disorder
       Region 5vvt A 604-663 order
       Region 5vvt A 664-678 disorder
       Region 5vvt A 679-700 order
       Region 5vvt A 701-704 disorder
Seq 60-400,553-704 Hetero tetramer : IID00015Complex
 Evidence X-RAY 5un8 B Reference
       Region 5un8 B 60-333 order
       Region 5un8 B 334-373 disorder
       Region 5un8 B 374-398 order
       Region 5un8 B 399-400 disorder
       Region 5un8 B 553-592 order
       Region 5un8 B 593-602 disorder
       Region 5un8 B 603-665 order
       Region 5un8 B 666-678 disorder
       Region 5un8 B 679-700 order
       Region 5un8 B 701-704 disorder
 Evidence X-RAY 5un8 D Reference
       Region 5un8 D 60-336 order
       Region 5un8 D 337-372 disorder
       Region 5un8 D 373-391 order
       Region 5un8 D 392-400 disorder
       Region 5un8 D 553-592 order
       Region 5un8 D 593-603 disorder
       Region 5un8 D 604-694 order
       Region 5un8 D 695-704 disorder
Seq 60-400,553-704 Homo dimer :
 Evidence X-RAY 5tke A Reference
       Region 5tke A 60-176 order
       Region 5tke A 177-179 disorder
       Region 5tke A 180-334 order
       Region 5tke A 335-372 disorder
       Region 5tke A 373-398 order
       Region 5tke A 399-400 disorder
       Region 5tke A 553-589 order
       Region 5tke A 590-601 disorder
       Region 5tke A 602-663 order
       Region 5tke A 664-680 disorder
       Region 5tke A 681-701 order
       Region 5tke A 702-704 disorder
 Evidence X-RAY 5tke B Reference
       Region 5tke B 60-175 order
       Region 5tke B 176-181 disorder
       Region 5tke B 182-334 order
       Region 5tke B 335-373 disorder
       Region 5tke B 374-392 order
       Region 5tke B 393-400 disorder
       Region 5tke B 553-592 order
       Region 5tke B 593-602 disorder
       Region 5tke B 603-694 order
       Region 5tke B 695-704 disorder
Seq 60-400,553-704 Hetero tetramer : IID00015Complex
 Evidence X-RAY 5un8 A Reference
       Region 5un8 A 60-333 order
       Region 5un8 A 334-373 disorder
       Region 5un8 A 374-398 order
       Region 5un8 A 399-400 disorder
       Region 5un8 A 553-592 order
       Region 5un8 A 593-603 disorder
       Region 5un8 A 604-665 order
       Region 5un8 A 666-678 disorder
       Region 5un8 A 679-700 order
       Region 5un8 A 701-704 disorder
 Evidence X-RAY 5un8 C Reference
       Region 5un8 C 60-336 order
       Region 5un8 C 337-372 disorder
       Region 5un8 C 373-391 order
       Region 5un8 C 392-400 disorder
       Region 5un8 C 553-592 order
       Region 5un8 C 593-603 disorder
       Region 5un8 C 604-694 order
       Region 5un8 C 695-704 disorder
Seq 402-408 Hetero dimer : Q0TR53
 Evidence X-RAY 2ydq T Reference
       Region 2ydq T 402-407 order
       Region 2ydq T 408-408 disorder
Seqphosphorylation
    364-364 Phosphoserine
 
Prediction
NeProc
Disorder 1-48,402-548,668-672
Order 49-401,549-595,600-667,673-809,816-916
ProS 1-4,40-48,414-418,526-530,668-672
AlphaFold
Disorder 1-58,340-372,396-549,594-599,665-670,672-682,697-697,738-745,810-811
Order 59-339,373-395,550-593,600-664,671-671,683-696,698-737,746-809,812-916
Pfam Hmmer
PF07555 62-379 7.4e-177
SEG 43-57 ,449-458
Function
Function in SwissProt
Isoform 1
Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc and 4-methylumbelliferone-GlcNAc as substrates but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro) (PubMed:11148210). Does not bind acetyl-CoA and does not have histone acetyltransferase activity (PubMed:24088714).
Isoform 3
Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc as substrate but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro), but has about six times lower specific activity than isoform 1.