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IID00644
 UniprotO95163
ProteinElongator complex protein 1
GeneELP1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 xml
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1332
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 715-1332 Homo dimer :
 Evidence X-RAY 5cqr A Reference
       Region 5cqr A 715-719 disorder
       Region 5cqr A 720-800 order
       Region 5cqr A 801-810 disorder
       Region 5cqr A 811-911 order
       Region 5cqr A 912-914 disorder
       Region 5cqr A 915-1131 order
       Region 5cqr A 1132-1224 disorder
       Region 5cqr A 1225-1269 order
       Region 5cqr A 1270-1320 disorder
       Region 5cqr A 1321-1331 order
       Region 5cqr A 1332-1332 disorder
Seqphosphorylation
    471-471 Phosphoserine
    804-804 Phosphoserine
    867-867 Phosphoserine
    1171-1171 Phosphoserine
    1174-1174 Phosphoserine
 
Prediction
NeProc
Disorder 1157-1207,1284-1319
Order 1-803,811-1156,1208-1276,1320-1332
ProS 1157-1162,1172-1182,1187-1191,1202-1207,1284-1300,1308-1319
AlphaFold
Disorder 158-186,309-315,341-341,455-458,469-476,491-497,522-522,535-540,667-667,678-685,799-813,863-869,1148-1201,1276-1291,1293-1293,1295-1314,1322-1324
Order 1-157,187-308,316-340,342-454,459-468,477-490,498-521,523-534,541-666,668-677,686-798,814-862,870-1147,1202-1275,1292-1292,1294-1294,1315-1321,1325-1332
SEG 1077-1095 ,1185-1204 ,1213-1222
Function
Function in SwissProt
Component of the RNA polymerase II elongator complex, a multiprotein complex associated with the RNA polymerase II (Pol II) holoenzyme, and which is involved in transcriptional elongation (PubMed:11714725, PubMed:11818576). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (PubMed:29332244). Involved in neurogenesis (By similarity). Regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha-tubulin acetylation (By similarity). May act as a scaffold protein that may assemble active IKK-MAP3K14 complexes (IKKA, IKKB and MAP3K14/NIK) (PubMed:9751059).