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IID00646
 UniprotP01130
ProteinLow-density lipoprotein receptor
GeneLDLR
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
860
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 4-788 Hetero trimer : Q8NBP7
 Evidence X-RAY 3m0c C Reference
       Region 3m0c C 4-275 disorder
       Region 3m0c C 276-456 order
       Region 3m0c C 457-464 disorder
       Region 3m0c C 465-713 order
       Region 3m0c C 714-788 disorder
Seq 20-67 Monomer :
 Evidence NMR 1ldl A Reference
       Region 1ldl A 20-21 disorder
       Region 1ldl A 22-67 order
       Region 1ldl A 22-26 high_rmsd
       Region 1ldl A 66-67 high_rmsd
Seq 22-104 Monomer :
 Evidence NMR 1f5y A Reference
       Region 1f5y A 22-104 order
Seq 22-720 Monomer :
 Evidence X-RAY 1n7d A Reference
       Region 1n7d A 22-64 disorder
       Region 1n7d A 65-77 order
       Region 1n7d A 78-79 disorder
       Region 1n7d A 80-95 order
       Region 1n7d A 96-96 disorder
       Region 1n7d A 97-119 order
       Region 1n7d A 120-123 disorder
       Region 1n7d A 124-408 order
       Region 1n7d A 409-409 disorder
       Region 1n7d A 410-461 order
       Region 1n7d A 462-462 disorder
       Region 1n7d A 463-473 order
       Region 1n7d A 474-475 disorder
       Region 1n7d A 476-714 order
       Region 1n7d A 715-720 disorder
Seq 64-104 Monomer :
 Evidence NMR 1ldr A Reference
       Region 1ldr A 64-104 order
       Region 1ldr A 64-67 high_rmsd
Seq 82-104 Monomer : IID00681Complex
 Evidence NMR 2m7p A Reference
       Region 2m7p A 82-104 order
Seq 107-186 Hetero dimer : P30533
 Evidence X-RAY 2fcw B Reference
       Region 2fcw B 107-184 order
       Region 2fcw B 185-186 disorder
Seq 144-235 Monomer :
 Evidence NMR 2lgp A Reference
       Region 2lgp A 144-235 order
Seq 147-186 Hetero dimer : IID00647Complex
 Evidence NMR 2kri B Reference
       Region 2kri B 147-184 order
       Region 2kri B 185-186 disorder
Seq 196-232 Monomer :
 Evidence X-RAY 1ajj A Reference
       Region 1ajj A 196-232 order
Seq 233-272 Monomer :
 Evidence NMR 1f8z A Reference
       Region 1f8z A 234-272 order
 Evidence NMR 1d2j A Reference
       Region 1d2j A 233-272 order
Seq 272-353 Monomer :
 Evidence NMR 1xfe A Reference
       Region 1xfe A 272-353 order
       Region 1xfe A 272-275 high_rmsd
Seq 276-715 Hetero trimer : Q8NBP7
 Evidence X-RAY 3p5c L Reference
       Region 3p5c L 276-715 order
 Evidence X-RAY 3p5b L Reference
       Region 3p5b L 316-456 order
       Region 3p5b L 457-462 disorder
       Region 3p5b L 463-715 order
Seq 314-339 Hetero trimer : Q8NBP7
 Evidence X-RAY 4ne9 D Reference
       Region 4ne9 D 314-339 order
Seq 314-339 Monomer :
 Evidence NMR 2mg9 A Reference
       Region 2mg9 A 314-339 order
Seq 314-393 Hetero trimer : Q8NBP7
 Evidence X-RAY 2w2q E Reference
       Region 2w2q E 314-353 order
       Region 2w2q E 354-393 disorder
 Evidence X-RAY 2w2p E Reference
       Region 2w2p E 314-353 order
       Region 2w2p E 354-393 disorder
 Evidence X-RAY 2w2o E Reference
       Region 2w2o E 314-353 order
       Region 2w2o E 354-393 disorder
 Evidence X-RAY 2w2n E Reference
       Region 2w2n E 314-354 order
       Region 2w2n E 355-393 disorder
 Evidence X-RAY 2w2m E Reference
       Region 2w2m E 314-354 order
       Region 2w2m E 355-393 disorder
Seq 314-393 Hetero trimer : Q8NBP7
 Evidence X-RAY 3gcx E Reference
       Region 3gcx E 314-353 order
       Region 3gcx E 354-393 disorder
 Evidence X-RAY 3gcw E Reference
       Region 3gcw E 314-353 order
       Region 3gcw E 354-393 disorder
 Evidence X-RAY 3bps E Reference
       Region 3bps E 314-353 order
       Region 3bps E 354-393 disorder
Seq 314-395 Monomer :
 Evidence NMR 1i0u A Reference
       Region 1i0u A 314-395 order
 Evidence NMR 1hz8 A Reference
       Region 1hz8 A 314-395 order
       Region 1hz8 A 314-316 high_rmsd
       Region 1hz8 A 381-395 high_rmsd
 Evidence NMR 1hj7 A Reference
       Region 1hj7 A 314-393 order
       Region 1hj7 A 314-314 high_rmsd
Seq 398-713 Monomer :
 Evidence X-RAY 1ijq B Reference
       Region 1ijq B 398-414 order
       Region 1ijq B 415-416 disorder
       Region 1ijq B 417-455 order
       Region 1ijq B 456-464 disorder
       Region 1ijq B 465-713 order
 Evidence X-RAY 1ijq A Reference
       Region 1ijq A 398-456 order
       Region 1ijq A 457-464 disorder
       Region 1ijq A 465-713 order
Seq 819-832 Hetero dimer : IID50263Complex
 Evidence X-RAY 3so6 Q Reference
       Region 3so6 Q 819-819 disorder
       Region 3so6 Q 820-832 order
Seqphosphorylation
    724-724 Phosphothreonine
 
Prediction
NeProc
Disorder 1-2,60-66,858-860
Order 3-59,67-857
ProS 1-2,60-66
AlphaFold
Disorder 1-26,29-30,43-44,46-49,60-60,63-71,77-80,105-108,145-148,185-196,199-200,232-235,237-239,271-279,387-388,461-463,720-791,815-860
Order 27-28,31-42,45-45,50-59,61-62,72-76,81-104,109-144,149-184,197-198,201-231,236-236,240-270,280-386,389-460,464-719,792-814
Pfam Hmmer
PF00057 25-63 1.4e-17
PF00057 66-104 2.8e-16
PF00057 107-143 2.8e-16
PF00057 146-184 6.5e-20
PF00057 195-231 3.4e-18
PF00057 234-270 2.2e-16
PF00057 274-313 5e-15
PF00008 318-352 1.9e-07
PF07645 354-392 1e-09
PF00058 439-484 3.8e-17
PF00058 486-527 2.8e-16
PF00058 529-571 8.2e-16
PF00058 573-616 6.5e-15
PF00058 617-657 2.6e-08
SEG 11-24 ,713-726 ,797-809
Function
Function in SwissProt
Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits.
(Microbial infection) Acts as a receptor for hepatitis C virus in hepatocytes, but not through a direct interaction with viral proteins.
(Microbial infection) Acts as a receptor for Vesicular stomatitis virus.
(Microbial infection) In case of HIV-1 infection, may function as a receptor for extracellular Tat in neurons, mediating its internalization in uninfected cells.