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IID00649
 UniprotP10451
ProteinOsteopontin
GeneSPP1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 xml
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
314
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 40-51 Hetero trimer :
 Evidence X-RAY 3cxd P Reference
       Region 3cxd P 40-41 disorder
       Region 3cxd P 42-50 order
       Region 3cxd P 51-51 disorder
Seq 40-51 Hetero trimer :
 Evidence X-RAY 3dsf P Reference
       Region 3dsf P 40-43 disorder
       Region 3dsf P 44-50 order
       Region 3dsf P 51-51 disorder
Seqphosphorylation
    225-225 Phosphotyrosine
    195-195 Phosphoserine; by FAM20C
    191-191 Phosphoserine; by FAM20C
    190-190 Phosphothreonine; by FAM20C
    126-126 Phosphoserine
    129-129 Phosphoserine
    185-185 Phosphothreonine
    120-120 Phosphoserine
    123-123 Phosphoserine
    105-105 Phosphoserine
    108-108 Phosphoserine
    117-117 Phosphoserine
    81-81 Phosphoserine
    99-99 Phosphoserine
    102-102 Phosphoserine
    76-76 Phosphoserine
    78-78 Phosphoserine
    63-63 Phosphoserine; by FAM20C
    66-66 Phosphothreonine
    27-27 Phosphoserine; by FAM20C
    62-62 Phosphoserine; by FAM20C
    24-24 Phosphoserine
    26-26 Phosphoserine; by FAM20C
    303-303 Phosphoserine; by FAM20C
    311-311 Phosphoserine; by FAM20C
    310-310 Phosphoserine; by FAM20C
    308-308 Phosphoserine; by FAM20C
    215-215 Phosphoserine; by FAM20C
    291-291 Phosphoserine; by FAM20C
    280-280 Phosphoserine; by FAM20C
    275-275 Phosphoserine; by FAM20C
    270-270 Phosphoserine; by FAM20C
    267-267 Phosphoserine; by FAM20C
    263-263 Phosphoserine; by FAM20C
    258-258 Phosphoserine; by FAM20C
    243-243 Phosphoserine; by FAM20C
    237-237 Phosphothreonine; by FAM20C
    254-254 Phosphoserine; by FAM20C
    239-239 Phosphoserine; by FAM20C
    234-234 Phosphoserine; by FAM20C
    228-228 Phosphoserine; by FAM20C
    224-224 Phosphoserine; by FAM20C
    219-219 Phosphoserine; by FAM20C
 
Prediction
NeProc
Disorder 1-134,147-149,172-314
Order 135-146,150-171
ProS 1-33,54-77,130-134,147-149,172-193,200-240,247-260,269-289,295-314
AlphaFold
Disorder 17-124,126-126,128-314
Order 1-16,125-125,127-127
Pfam Hmmer
PF00865 1-314 7.6e-225
SEG 81-131 ,272-282
Function
Function in SwissProt
Major non-collagenous bone protein that binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction.
Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity.