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IID00650
 UniprotP11362
ProteinFibroblast growth factor receptor 1
GeneFGFR1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
822
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 38-123 Monomer :
 Evidence NMR 2cr3 A Reference
       Region 2cr3 A 38-123 order
Seq 141-365 Hetero tetramer : IID00438Complex
 Evidence X-RAY 1fq9 D Reference
       Region 1fq9 D 141-148 disorder
       Region 1fq9 D 149-292 order
       Region 1fq9 D 293-307 disorder
       Region 1fq9 D 308-359 order
       Region 1fq9 D 360-365 disorder
 Evidence X-RAY 1fq9 C Reference
       Region 1fq9 C 141-148 disorder
       Region 1fq9 C 149-359 order
       Region 1fq9 C 360-365 disorder
 Evidence X-RAY 1cvs D Reference
       Region 1cvs D 141-148 disorder
       Region 1cvs D 149-292 order
       Region 1cvs D 293-307 disorder
       Region 1cvs D 308-359 order
       Region 1cvs D 360-365 disorder
 Evidence X-RAY 1cvs C Reference
       Region 1cvs C 141-148 disorder
       Region 1cvs C 149-359 order
       Region 1cvs C 360-365 disorder
Seq 141-365 Hetero tetramer : P05230
 Evidence X-RAY 1evt D Reference
       Region 1evt D 141-146 disorder
       Region 1evt D 147-293 order
       Region 1evt D 294-305 disorder
       Region 1evt D 306-314 order
       Region 1evt D 315-323 disorder
       Region 1evt D 324-359 order
       Region 1evt D 360-365 disorder
 Evidence X-RAY 1evt C Reference
       Region 1evt C 141-146 disorder
       Region 1evt C 147-293 order
       Region 1evt C 294-303 disorder
       Region 1evt C 304-311 order
       Region 1evt C 312-323 disorder
       Region 1evt C 324-359 order
       Region 1evt C 360-365 disorder
Seq 142-365 Hetero trimer : Q9GZV9,Q9UEF7
 Evidence X-RAY 5w21 C Reference
       Region 5w21 C 142-148 disorder
       Region 5w21 C 149-361 order
       Region 5w21 C 362-365 disorder
Seq 142-365 Hetero dimer : P05230
 Evidence X-RAY 3ojv D Reference
       Region 3ojv D 142-146 disorder
       Region 3ojv D 147-359 order
       Region 3ojv D 360-365 disorder
 Evidence X-RAY 3ojv C Reference
       Region 3ojv C 142-146 disorder
       Region 3ojv C 147-359 order
       Region 3ojv C 360-365 disorder
Seq 142-365 Hetero dimer : P31371
 Evidence X-RAY 5w59 B Reference
       Region 5w59 B 142-146 disorder
       Region 5w59 B 147-298 order
       Region 5w59 B 299-304 disorder
       Region 5w59 B 305-360 order
       Region 5w59 B 361-365 disorder
Seq 409-430 Hetero dimer : IID00675Complex
 Evidence NMR 1xr0 A Reference
       Region 1xr0 A 409-430 order
Seq 437-822 Homo dimer :
 Evidence X-RAY 4v05 B Reference
       Region 4v05 B 458-458 disorder
       Region 4v05 B 459-501 order
       Region 4v05 B 502-504 disorder
       Region 4v05 B 505-579 order
       Region 4v05 B 580-592 disorder
       Region 4v05 B 593-644 order
       Region 4v05 B 645-648 disorder
       Region 4v05 B 649-764 order
       Region 4v05 B 765-765 disorder
 Evidence X-RAY 4v05 A Reference
       Region 4v05 A 458-463 disorder
       Region 4v05 A 464-580 order
       Region 4v05 A 581-591 disorder
       Region 4v05 A 592-646 order
       Region 4v05 A 647-650 disorder
       Region 4v05 A 651-765 order
 Evidence X-RAY 4v04 B Reference
       Region 4v04 B 458-579 order
       Region 4v04 B 580-592 disorder
       Region 4v04 B 593-644 order
       Region 4v04 B 645-650 disorder
       Region 4v04 B 651-765 order
 Evidence X-RAY 4v04 A Reference
       Region 4v04 A 458-462 disorder
       Region 4v04 A 463-486 order
       Region 4v04 A 487-489 disorder
       Region 4v04 A 490-584 order
       Region 4v04 A 585-586 disorder
       Region 4v04 A 587-644 order
       Region 4v04 A 645-650 disorder
       Region 4v04 A 651-765 order
 Evidence X-RAY 4v01 B Reference
       Region 4v01 B 458-460 disorder
       Region 4v01 B 461-487 order
       Region 4v01 B 488-489 disorder
       Region 4v01 B 490-501 order
       Region 4v01 B 502-504 disorder
       Region 4v01 B 505-578 order
       Region 4v01 B 579-593 disorder
       Region 4v01 B 594-642 order
       Region 4v01 B 643-650 disorder
       Region 4v01 B 651-763 order
       Region 4v01 B 764-765 disorder
 Evidence X-RAY 4v01 A Reference
       Region 4v01 A 458-464 disorder
       Region 4v01 A 465-485 order
       Region 4v01 A 486-489 disorder
       Region 4v01 A 490-501 order
       Region 4v01 A 502-503 disorder
       Region 4v01 A 504-579 order
       Region 4v01 A 580-593 disorder
       Region 4v01 A 594-642 order
       Region 4v01 A 643-650 disorder
       Region 4v01 A 651-765 order
 Evidence X-RAY 5a4c B Reference
       Region 5a4c B 461-501 order
       Region 5a4c B 502-504 disorder
       Region 5a4c B 505-579 order
       Region 5a4c B 580-592 disorder
       Region 5a4c B 593-645 order
       Region 5a4c B 646-650 disorder
       Region 5a4c B 651-765 order
 Evidence X-RAY 5a4c A Reference
       Region 5a4c A 461-463 disorder
       Region 5a4c A 464-486 order
       Region 5a4c A 487-488 disorder
       Region 5a4c A 489-644 order
       Region 5a4c A 645-650 disorder
       Region 5a4c A 651-765 order
 Evidence X-RAY 5a46 B Reference
       Region 5a46 B 437-457 disorder
       Region 5a46 B 458-502 order
       Region 5a46 B 503-504 disorder
       Region 5a46 B 505-579 order
       Region 5a46 B 580-588 disorder
       Region 5a46 B 589-765 order
       Region 5a46 B 766-822 disorder
 Evidence X-RAY 5a46 A Reference
       Region 5a46 A 437-463 disorder
       Region 5a46 A 464-581 order
       Region 5a46 A 582-591 disorder
       Region 5a46 A 592-647 order
       Region 5a46 A 648-650 disorder
       Region 5a46 A 651-765 order
       Region 5a46 A 766-822 disorder
 Evidence X-RAY 5vnd B Reference
       Region 5vnd B 458-459 disorder
       Region 5vnd B 460-580 order
       Region 5vnd B 581-591 disorder
       Region 5vnd B 592-765 order
 Evidence X-RAY 5vnd A Reference
       Region 5vnd A 458-462 disorder
       Region 5vnd A 463-647 order
       Region 5vnd A 648-648 disorder
       Region 5vnd A 649-765 order
 Evidence X-RAY 4nka B Reference
       Region 4nka B 458-502 order
       Region 4nka B 503-504 disorder
       Region 4nka B 505-579 order
       Region 4nka B 580-592 disorder
       Region 4nka B 593-642 order
       Region 4nka B 643-648 disorder
       Region 4nka B 649-765 order
 Evidence X-RAY 4nka A Reference
       Region 4nka A 458-463 disorder
       Region 4nka A 464-486 order
       Region 4nka A 487-490 disorder
       Region 4nka A 491-579 order
       Region 4nka A 580-591 disorder
       Region 4nka A 592-643 order
       Region 4nka A 644-650 disorder
       Region 4nka A 651-765 order
 Evidence X-RAY 4nk9 B Reference
       Region 4nk9 B 458-459 disorder
       Region 4nk9 B 460-502 order
       Region 4nk9 B 503-504 disorder
       Region 4nk9 B 505-579 order
       Region 4nk9 B 580-593 disorder
       Region 4nk9 B 594-643 order
       Region 4nk9 B 644-651 disorder
       Region 4nk9 B 652-765 order
 Evidence X-RAY 4nk9 A Reference
       Region 4nk9 A 458-463 disorder
       Region 4nk9 A 464-501 order
       Region 4nk9 A 502-502 disorder
       Region 4nk9 A 503-579 order
       Region 4nk9 A 580-592 disorder
       Region 4nk9 A 593-643 order
       Region 4nk9 A 644-650 disorder
       Region 4nk9 A 651-765 order
 Evidence X-RAY 3js2 B Reference
       Region 3js2 B 458-458 disorder
       Region 3js2 B 459-579 order
       Region 3js2 B 580-592 disorder
       Region 3js2 B 593-762 order
       Region 3js2 B 763-765 disorder
 Evidence X-RAY 3js2 A Reference
       Region 3js2 A 458-463 disorder
       Region 3js2 A 464-581 order
       Region 3js2 A 582-588 disorder
       Region 3js2 A 589-765 order
 Evidence X-RAY 2fgi B Reference
       Region 2fgi B 456-460 disorder
       Region 2fgi B 461-500 order
       Region 2fgi B 501-504 disorder
       Region 2fgi B 505-577 order
       Region 2fgi B 578-593 disorder
       Region 2fgi B 594-645 order
       Region 2fgi B 646-651 disorder
       Region 2fgi B 652-656 order
       Region 2fgi B 657-659 disorder
       Region 2fgi B 660-761 order
       Region 2fgi B 762-765 disorder
 Evidence X-RAY 2fgi A Reference
       Region 2fgi A 456-463 disorder
       Region 2fgi A 464-485 order
       Region 2fgi A 486-490 disorder
       Region 2fgi A 491-500 order
       Region 2fgi A 501-504 disorder
       Region 2fgi A 505-579 order
       Region 2fgi A 580-593 disorder
       Region 2fgi A 594-645 order
       Region 2fgi A 646-646 disorder
       Region 2fgi A 647-657 order
       Region 2fgi A 658-658 disorder
       Region 2fgi A 659-762 order
       Region 2fgi A 763-765 disorder
 Evidence X-RAY 1fgk B Reference
       Region 1fgk B 456-460 disorder
       Region 1fgk B 461-500 order
       Region 1fgk B 501-504 disorder
       Region 1fgk B 505-577 order
       Region 1fgk B 578-593 disorder
       Region 1fgk B 594-645 order
       Region 1fgk B 646-651 disorder
       Region 1fgk B 652-656 order
       Region 1fgk B 657-659 disorder
       Region 1fgk B 660-761 order
       Region 1fgk B 762-765 disorder
 Evidence X-RAY 1fgk A Reference
       Region 1fgk A 456-463 disorder
       Region 1fgk A 464-485 order
       Region 1fgk A 486-490 disorder
       Region 1fgk A 491-500 order
       Region 1fgk A 501-504 disorder
       Region 1fgk A 505-579 order
       Region 1fgk A 580-591 disorder
       Region 1fgk A 592-762 order
       Region 1fgk A 763-765 disorder
 Evidence X-RAY 4f65 B Reference
       Region 4f65 B 458-459 disorder
       Region 4f65 B 460-501 order
       Region 4f65 B 502-504 disorder
       Region 4f65 B 505-578 order
       Region 4f65 B 579-593 disorder
       Region 4f65 B 594-642 order
       Region 4f65 B 643-649 disorder
       Region 4f65 B 650-763 order
       Region 4f65 B 764-765 disorder
 Evidence X-RAY 4f65 A Reference
       Region 4f65 A 458-463 disorder
       Region 4f65 A 464-501 order
       Region 4f65 A 502-503 disorder
       Region 4f65 A 504-579 order
       Region 4f65 A 580-590 disorder
       Region 4f65 A 591-642 order
       Region 4f65 A 643-652 disorder
       Region 4f65 A 653-765 order
 Evidence X-RAY 4f64 B Reference
       Region 4f64 B 458-460 disorder
       Region 4f64 B 461-500 order
       Region 4f64 B 501-504 disorder
       Region 4f64 B 505-577 order
       Region 4f64 B 578-593 disorder
       Region 4f64 B 594-645 order
       Region 4f64 B 646-651 disorder
       Region 4f64 B 652-656 order
       Region 4f64 B 657-659 disorder
       Region 4f64 B 660-761 order
       Region 4f64 B 762-765 disorder
 Evidence X-RAY 4f64 A Reference
       Region 4f64 A 458-463 disorder
       Region 4f64 A 464-485 order
       Region 4f64 A 486-490 disorder
       Region 4f64 A 491-500 order
       Region 4f64 A 501-504 disorder
       Region 4f64 A 505-579 order
       Region 4f64 A 580-591 disorder
       Region 4f64 A 592-762 order
       Region 4f64 A 763-765 disorder
 Evidence X-RAY 4f63 B Reference
       Region 4f63 B 458-460 disorder
       Region 4f63 B 461-488 order
       Region 4f63 B 489-489 disorder
       Region 4f63 B 490-500 order
       Region 4f63 B 501-504 disorder
       Region 4f63 B 505-577 order
       Region 4f63 B 578-593 disorder
       Region 4f63 B 594-645 order
       Region 4f63 B 646-651 disorder
       Region 4f63 B 652-656 order
       Region 4f63 B 657-659 disorder
       Region 4f63 B 660-761 order
       Region 4f63 B 762-765 disorder
 Evidence X-RAY 4f63 A Reference
       Region 4f63 A 458-463 disorder
       Region 4f63 A 464-485 order
       Region 4f63 A 486-490 disorder
       Region 4f63 A 491-500 order
       Region 4f63 A 501-504 disorder
       Region 4f63 A 505-579 order
       Region 4f63 A 580-591 disorder
       Region 4f63 A 592-762 order
       Region 4f63 A 763-765 disorder
Seq 456-774 Monomer :
 Evidence X-RAY 4zsa B Reference
       Region 4zsa B 458-461 disorder
       Region 4zsa B 462-579 order
       Region 4zsa B 580-591 disorder
       Region 4zsa B 592-644 order
       Region 4zsa B 645-650 disorder
       Region 4zsa B 651-761 order
       Region 4zsa B 762-765 disorder
 Evidence X-RAY 4zsa A Reference
       Region 4zsa A 458-464 disorder
       Region 4zsa A 465-579 order
       Region 4zsa A 580-591 disorder
       Region 4zsa A 592-765 order
 Evidence X-RAY 4wun B Reference
       Region 4wun B 459-460 disorder
       Region 4wun B 461-500 order
       Region 4wun B 501-503 disorder
       Region 4wun B 504-579 order
       Region 4wun B 580-593 disorder
       Region 4wun B 594-644 order
       Region 4wun B 645-661 disorder
       Region 4wun B 662-762 order
       Region 4wun B 763-765 disorder
 Evidence X-RAY 4wun A Reference
       Region 4wun A 459-464 disorder
       Region 4wun A 465-579 order
       Region 4wun A 580-580 disorder
       Region 4wun A 581-644 order
       Region 4wun A 645-662 disorder
       Region 4wun A 663-765 order
 Evidence X-RAY 5vnd B Reference
       Region 5vnd B 458-459 disorder
       Region 5vnd B 460-580 order
       Region 5vnd B 581-591 disorder
       Region 5vnd B 592-765 order
 Evidence X-RAY 5vnd A Reference
       Region 5vnd A 458-462 disorder
       Region 5vnd A 463-647 order
       Region 5vnd A 648-648 disorder
       Region 5vnd A 649-765 order
 Evidence X-RAY 4uwy B Reference
       Region 4uwy B 458-458 disorder
       Region 4uwy B 459-486 order
       Region 4uwy B 487-489 disorder
       Region 4uwy B 490-578 order
       Region 4uwy B 579-592 disorder
       Region 4uwy B 593-647 order
       Region 4uwy B 648-661 disorder
       Region 4uwy B 662-762 order
       Region 4uwy B 763-765 disorder
 Evidence X-RAY 4uwy A Reference
       Region 4uwy A 458-461 disorder
       Region 4uwy A 462-485 order
       Region 4uwy A 486-490 disorder
       Region 4uwy A 491-762 order
       Region 4uwy A 763-765 disorder
 Evidence X-RAY 4uwc B Reference
       Region 4uwc B 458-458 disorder
       Region 4uwc B 459-501 order
       Region 4uwc B 502-503 disorder
       Region 4uwc B 504-585 order
       Region 4uwc B 586-588 disorder
       Region 4uwc B 589-764 order
       Region 4uwc B 765-765 disorder
 Evidence X-RAY 4uwc A Reference
       Region 4uwc A 458-464 disorder
       Region 4uwc A 465-585 order
       Region 4uwc A 586-586 disorder
       Region 4uwc A 587-765 order
 Evidence X-RAY 4uwb B Reference
       Region 4uwb B 458-458 disorder
       Region 4uwb B 459-502 order
       Region 4uwb B 503-504 disorder
       Region 4uwb B 505-585 order
       Region 4uwb B 586-588 disorder
       Region 4uwb B 589-646 order
       Region 4uwb B 647-649 disorder
       Region 4uwb B 650-765 order
 Evidence X-RAY 4uwb A Reference
       Region 4uwb A 458-463 disorder
       Region 4uwb A 464-584 order
       Region 4uwb A 585-586 disorder
       Region 4uwb A 587-647 order
       Region 4uwb A 648-648 disorder
       Region 4uwb A 649-765 order
 Evidence X-RAY 5ur1 B Reference
       Region 5ur1 B 459-463 disorder
       Region 5ur1 B 464-501 order
       Region 5ur1 B 502-503 disorder
       Region 5ur1 B 504-578 order
       Region 5ur1 B 579-593 disorder
       Region 5ur1 B 594-644 order
       Region 5ur1 B 645-662 disorder
       Region 5ur1 B 663-763 order
       Region 5ur1 B 764-765 disorder
 Evidence X-RAY 5ur1 A Reference
       Region 5ur1 A 459-463 disorder
       Region 5ur1 A 464-487 order
       Region 5ur1 A 488-488 disorder
       Region 5ur1 A 489-579 order
       Region 5ur1 A 580-584 disorder
       Region 5ur1 A 585-644 order
       Region 5ur1 A 645-662 disorder
       Region 5ur1 A 663-765 order
 Evidence X-RAY 5uq0 B Reference
       Region 5uq0 B 459-462 disorder
       Region 5uq0 B 463-486 order
       Region 5uq0 B 487-489 disorder
       Region 5uq0 B 490-500 order
       Region 5uq0 B 501-506 disorder
       Region 5uq0 B 507-577 order
       Region 5uq0 B 578-593 disorder
       Region 5uq0 B 594-644 order
       Region 5uq0 B 645-661 disorder
       Region 5uq0 B 662-672 order
       Region 5uq0 B 673-674 disorder
       Region 5uq0 B 675-762 order
       Region 5uq0 B 763-765 disorder
 Evidence X-RAY 5uq0 A Reference
       Region 5uq0 A 459-463 disorder
       Region 5uq0 A 464-486 order
       Region 5uq0 A 487-488 disorder
       Region 5uq0 A 489-502 order
       Region 5uq0 A 503-504 disorder
       Region 5uq0 A 505-578 order
       Region 5uq0 A 579-592 disorder
       Region 5uq0 A 593-644 order
       Region 5uq0 A 645-661 disorder
       Region 5uq0 A 662-706 order
       Region 5uq0 A 707-707 disorder
       Region 5uq0 A 708-765 order
 Evidence X-RAY 3tt0 B Reference
       Region 3tt0 B 456-458 disorder
       Region 3tt0 B 459-577 order
       Region 3tt0 B 578-593 disorder
       Region 3tt0 B 594-645 order
       Region 3tt0 B 646-662 disorder
       Region 3tt0 B 663-763 order
       Region 3tt0 B 764-765 disorder
 Evidence X-RAY 3tt0 A Reference
       Region 3tt0 A 456-460 disorder
       Region 3tt0 A 461-765 order
 Evidence X-RAY 4rwl B Reference
       Region 4rwl B 458-501 order
       Region 4rwl B 502-504 disorder
       Region 4rwl B 505-579 order
       Region 4rwl B 580-592 disorder
       Region 4rwl B 593-644 order
       Region 4rwl B 645-650 disorder
       Region 4rwl B 651-764 order
       Region 4rwl B 765-765 disorder
 Evidence X-RAY 4rwl A Reference
       Region 4rwl A 458-464 disorder
       Region 4rwl A 465-486 order
       Region 4rwl A 487-490 disorder
       Region 4rwl A 491-579 order
       Region 4rwl A 580-591 disorder
       Region 4rwl A 592-647 order
       Region 4rwl A 648-650 disorder
       Region 4rwl A 651-765 order
 Evidence X-RAY 4rwk B Reference
       Region 4rwk B 458-458 disorder
       Region 4rwk B 459-577 order
       Region 4rwk B 578-593 disorder
       Region 4rwk B 594-645 order
       Region 4rwk B 646-650 disorder
       Region 4rwk B 651-657 order
       Region 4rwk B 658-659 disorder
       Region 4rwk B 660-763 order
       Region 4rwk B 764-765 disorder
 Evidence X-RAY 4rwk A Reference
       Region 4rwk A 458-764 order
       Region 4rwk A 765-765 disorder
 Evidence X-RAY 4rwj B Reference
       Region 4rwj B 458-458 disorder
       Region 4rwj B 459-580 order
       Region 4rwj B 581-593 disorder
       Region 4rwj B 594-644 order
       Region 4rwj B 645-653 disorder
       Region 4rwj B 654-658 order
       Region 4rwj B 659-659 disorder
       Region 4rwj B 660-763 order
       Region 4rwj B 764-765 disorder
 Evidence X-RAY 4rwj A Reference
       Region 4rwj A 458-657 order
       Region 4rwj A 658-658 disorder
       Region 4rwj A 659-764 order
       Region 4rwj A 765-765 disorder
 Evidence X-RAY 4rwi B Reference
       Region 4rwi B 458-460 disorder
       Region 4rwi B 461-487 order
       Region 4rwi B 488-489 disorder
       Region 4rwi B 490-577 order
       Region 4rwi B 578-593 disorder
       Region 4rwi B 594-645 order
       Region 4rwi B 646-649 disorder
       Region 4rwi B 650-658 order
       Region 4rwi B 659-659 disorder
       Region 4rwi B 660-763 order
       Region 4rwi B 764-765 disorder
 Evidence X-RAY 4rwi A Reference
       Region 4rwi A 458-459 disorder
       Region 4rwi A 460-764 order
       Region 4rwi A 765-765 disorder
 Evidence X-RAY 3rhx A Reference
       Region 3rhx A 461-463 disorder
       Region 3rhx A 464-579 order
       Region 3rhx A 580-591 disorder
       Region 3rhx A 592-764 order
       Region 3rhx A 765-765 disorder
 Evidence X-RAY 3rhx B Reference
       Region 3rhx B 461-500 order
       Region 3rhx B 501-504 disorder
       Region 3rhx B 505-577 order
       Region 3rhx B 578-593 disorder
       Region 3rhx B 594-645 order
       Region 3rhx B 646-651 disorder
       Region 3rhx B 652-761 order
       Region 3rhx B 762-765 disorder
 Evidence X-RAY 5o4a B Reference
       Region 5o4a B 458-459 disorder
       Region 5o4a B 460-502 order
       Region 5o4a B 503-504 disorder
       Region 5o4a B 505-585 order
       Region 5o4a B 586-591 disorder
       Region 5o4a B 592-644 order
       Region 5o4a B 645-649 disorder
       Region 5o4a B 650-763 order
       Region 5o4a B 764-765 disorder
 Evidence X-RAY 5o4a A Reference
       Region 5o4a A 458-463 disorder
       Region 5o4a A 464-580 order
       Region 5o4a A 581-591 disorder
       Region 5o4a A 592-764 order
       Region 5o4a A 765-765 disorder
 Evidence X-RAY 5o49 B Reference
       Region 5o49 B 458-459 disorder
       Region 5o49 B 460-501 order
       Region 5o49 B 502-504 disorder
       Region 5o49 B 505-580 order
       Region 5o49 B 581-592 disorder
       Region 5o49 B 593-644 order
       Region 5o49 B 645-649 disorder
       Region 5o49 B 650-765 order
 Evidence X-RAY 5o49 A Reference
       Region 5o49 A 458-463 disorder
       Region 5o49 A 464-579 order
       Region 5o49 A 580-591 disorder
       Region 5o49 A 592-764 order
       Region 5o49 A 765-765 disorder
 Evidence X-RAY 4nks B Reference
       Region 4nks B 458-460 disorder
       Region 4nks B 461-488 order
       Region 4nks B 489-489 disorder
       Region 4nks B 490-500 order
       Region 4nks B 501-504 disorder
       Region 4nks B 505-577 order
       Region 4nks B 578-593 disorder
       Region 4nks B 594-645 order
       Region 4nks B 646-651 disorder
       Region 4nks B 652-656 order
       Region 4nks B 657-659 disorder
       Region 4nks B 660-761 order
       Region 4nks B 762-765 disorder
 Evidence X-RAY 4nks A Reference
       Region 4nks A 458-464 disorder
       Region 4nks A 465-485 order
       Region 4nks A 486-490 disorder
       Region 4nks A 491-498 order
       Region 4nks A 499-505 disorder
       Region 4nks A 506-517 order
       Region 4nks A 518-518 disorder
       Region 4nks A 519-579 order
       Region 4nks A 580-593 disorder
       Region 4nks A 594-644 order
       Region 4nks A 645-650 disorder
       Region 4nks A 651-762 order
       Region 4nks A 763-765 disorder
 Evidence X-RAY 3ky2 B Reference
       Region 3ky2 B 458-459 disorder
       Region 3ky2 B 460-487 order
       Region 3ky2 B 488-489 disorder
       Region 3ky2 B 490-577 order
       Region 3ky2 B 578-593 disorder
       Region 3ky2 B 594-645 order
       Region 3ky2 B 646-651 disorder
       Region 3ky2 B 652-763 order
       Region 3ky2 B 764-765 disorder
 Evidence X-RAY 3ky2 A Reference
       Region 3ky2 A 458-487 order
       Region 3ky2 A 488-489 disorder
       Region 3ky2 A 490-764 order
       Region 3ky2 A 765-765 disorder
 Evidence X-RAY 3kxx D Reference
       Region 3kxx D 458-575 order
       Region 3kxx D 576-594 disorder
       Region 3kxx D 595-762 order
       Region 3kxx D 763-765 disorder
 Evidence X-RAY 3kxx C Reference
       Region 3kxx C 458-575 order
       Region 3kxx C 576-594 disorder
       Region 3kxx C 595-762 order
       Region 3kxx C 763-765 disorder
 Evidence X-RAY 3kxx B Reference
       Region 3kxx B 458-459 disorder
       Region 3kxx B 460-764 order
       Region 3kxx B 765-765 disorder
 Evidence X-RAY 3kxx A Reference
       Region 3kxx A 458-460 disorder
       Region 3kxx A 461-765 order
 Evidence X-RAY 3gql C Reference
       Region 3gql C 458-462 disorder
       Region 3gql C 463-579 order
       Region 3gql C 580-592 disorder
       Region 3gql C 593-646 order
       Region 3gql C 647-662 disorder
       Region 3gql C 663-766 order
       Region 3gql C 767-774 disorder
 Evidence X-RAY 3gql B Reference
       Region 3gql B 458-462 disorder
       Region 3gql B 463-579 order
       Region 3gql B 580-590 disorder
       Region 3gql B 591-646 order
       Region 3gql B 647-662 disorder
       Region 3gql B 663-765 order
       Region 3gql B 766-774 disorder
 Evidence X-RAY 3gql A Reference
       Region 3gql A 458-462 disorder
       Region 3gql A 463-579 order
       Region 3gql A 580-592 disorder
       Region 3gql A 593-646 order
       Region 3gql A 647-658 disorder
       Region 3gql A 659-774 order
 Evidence X-RAY 5flf E Reference
       Region 5flf E 458-465 disorder
       Region 5flf E 466-484 order
       Region 5flf E 485-489 disorder
       Region 5flf E 490-517 order
       Region 5flf E 518-519 disorder
       Region 5flf E 520-577 order
       Region 5flf E 578-592 disorder
       Region 5flf E 593-645 order
       Region 5flf E 646-659 disorder
       Region 5flf E 660-705 order
       Region 5flf E 706-707 disorder
       Region 5flf E 708-761 order
       Region 5flf E 762-765 disorder
 Evidence X-RAY 5flf D Reference
       Region 5flf D 458-464 disorder
       Region 5flf D 465-582 order
       Region 5flf D 583-591 disorder
       Region 5flf D 592-763 order
       Region 5flf D 764-765 disorder
 Evidence X-RAY 5flf C Reference
       Region 5flf C 458-463 disorder
       Region 5flf C 464-500 order
       Region 5flf C 501-504 disorder
       Region 5flf C 505-578 order
       Region 5flf C 579-591 disorder
       Region 5flf C 592-763 order
       Region 5flf C 764-765 disorder
 Evidence X-RAY 5flf B Reference
       Region 5flf B 458-459 disorder
       Region 5flf B 460-579 order
       Region 5flf B 580-592 disorder
       Region 5flf B 593-764 order
       Region 5flf B 765-765 disorder
 Evidence X-RAY 5flf A Reference
       Region 5flf A 458-459 disorder
       Region 5flf A 460-584 order
       Region 5flf A 585-591 disorder
       Region 5flf A 592-762 order
       Region 5flf A 763-765 disorder
 Evidence X-RAY 1fgi B Reference
       Region 1fgi B 456-460 disorder
       Region 1fgi B 461-500 order
       Region 1fgi B 501-504 disorder
       Region 1fgi B 505-577 order
       Region 1fgi B 578-593 disorder
       Region 1fgi B 594-645 order
       Region 1fgi B 646-651 disorder
       Region 1fgi B 652-656 order
       Region 1fgi B 657-659 disorder
       Region 1fgi B 660-761 order
       Region 1fgi B 762-765 disorder
 Evidence X-RAY 1fgi A Reference
       Region 1fgi A 456-463 disorder
       Region 1fgi A 464-500 order
       Region 1fgi A 501-504 disorder
       Region 1fgi A 505-579 order
       Region 1fgi A 580-591 disorder
       Region 1fgi A 592-762 order
       Region 1fgi A 763-765 disorder
 Evidence X-RAY 5ew8 B Reference
       Region 5ew8 B 458-460 disorder
       Region 5ew8 B 461-579 order
       Region 5ew8 B 580-592 disorder
       Region 5ew8 B 593-646 order
       Region 5ew8 B 647-648 disorder
       Region 5ew8 B 649-765 order
 Evidence X-RAY 5ew8 A Reference
       Region 5ew8 A 458-463 disorder
       Region 5ew8 A 464-580 order
       Region 5ew8 A 581-591 disorder
       Region 5ew8 A 592-765 order
 Evidence X-RAY 3c4f B Reference
       Region 3c4f B 464-579 order
       Region 3c4f B 580-591 disorder
       Region 3c4f B 592-765 order
 Evidence X-RAY 3c4f A Reference
       Region 3c4f A 464-579 order
       Region 3c4f A 580-591 disorder
       Region 3c4f A 592-765 order
 Evidence X-RAY 5b7v B Reference
       Region 5b7v B 456-461 disorder
       Region 5b7v B 462-486 order
       Region 5b7v B 487-489 disorder
       Region 5b7v B 490-501 order
       Region 5b7v B 502-503 disorder
       Region 5b7v B 504-578 order
       Region 5b7v B 579-591 disorder
       Region 5b7v B 592-646 order
       Region 5b7v B 647-651 disorder
       Region 5b7v B 652-658 order
       Region 5b7v B 659-659 disorder
       Region 5b7v B 660-762 order
       Region 5b7v B 763-765 disorder
 Evidence X-RAY 5b7v A Reference
       Region 5b7v A 456-463 disorder
       Region 5b7v A 464-486 order
       Region 5b7v A 487-490 disorder
       Region 5b7v A 491-579 order
       Region 5b7v A 580-590 disorder
       Region 5b7v A 591-646 order
       Region 5b7v A 647-649 disorder
       Region 5b7v A 650-763 order
       Region 5b7v A 764-765 disorder
 Evidence X-RAY 5am7 B Reference
       Region 5am7 B 458-486 order
       Region 5am7 B 487-489 disorder
       Region 5am7 B 490-580 order
       Region 5am7 B 581-590 disorder
       Region 5am7 B 591-647 order
       Region 5am7 B 648-652 disorder
       Region 5am7 B 653-762 order
       Region 5am7 B 763-765 disorder
 Evidence X-RAY 5am7 A Reference
       Region 5am7 A 458-486 order
       Region 5am7 A 487-489 disorder
       Region 5am7 A 490-580 order
       Region 5am7 A 581-590 disorder
       Region 5am7 A 591-764 order
       Region 5am7 A 765-765 disorder
 Evidence X-RAY 5am6 B Reference
       Region 5am6 B 458-578 order
       Region 5am6 B 579-590 disorder
       Region 5am6 B 591-646 order
       Region 5am6 B 647-659 disorder
       Region 5am6 B 660-762 order
       Region 5am6 B 763-765 disorder
 Evidence X-RAY 5am6 A Reference
       Region 5am6 A 458-486 order
       Region 5am6 A 487-489 disorder
       Region 5am6 A 490-580 order
       Region 5am6 A 581-591 disorder
       Region 5am6 A 592-765 order
 Evidence X-RAY 1agw B Reference
       Region 1agw B 456-460 disorder
       Region 1agw B 461-500 order
       Region 1agw B 501-504 disorder
       Region 1agw B 505-577 order
       Region 1agw B 578-593 disorder
       Region 1agw B 594-645 order
       Region 1agw B 646-651 disorder
       Region 1agw B 652-656 order
       Region 1agw B 657-659 disorder
       Region 1agw B 660-761 order
       Region 1agw B 762-765 disorder
 Evidence X-RAY 1agw A Reference
       Region 1agw A 456-463 disorder
       Region 1agw A 464-485 order
       Region 1agw A 486-490 disorder
       Region 1agw A 491-500 order
       Region 1agw A 501-504 disorder
       Region 1agw A 505-579 order
       Region 1agw A 580-591 disorder
       Region 1agw A 592-762 order
       Region 1agw A 763-765 disorder
Seq 458-774 Hetero dimer : P10686
 Evidence X-RAY 3gqi A Reference
       Region 3gqi A 458-463 disorder
       Region 3gqi A 464-770 order
       Region 3gqi A 771-774 disorder
Seq 577-597 Monomer : P07333
 Evidence X-RAY 3krl A Reference
       Region 3krl A 577-577 order
       Region 3krl A 578-593 disorder
       Region 3krl A 594-597 order
Seq 577-597 Monomer : P07333
 Evidence X-RAY 3krj A Reference
       Region 3krj A 577-580 order
       Region 3krj A 581-593 disorder
       Region 3krj A 594-597 order
Seq 577-615 Monomer : P07333
 Evidence X-RAY 3dpk A Reference
       Region 3dpk A 577-593 disorder
       Region 3dpk A 594-615 order
Seqphosphorylation
    766-766 Phosphotyrosine; by autocatalysis
    730-730 Phosphotyrosine; by autocatalysis
    653-653 Phosphotyrosine; by autocatalysis
    654-654 Phosphotyrosine; by autocatalysis
    585-585 Phosphotyrosine; by autocatalysis
    583-583 Phosphotyrosine; by autocatalysis
    463-463 Phosphotyrosine; by autocatalysis
 
Prediction
NeProc
Disorder 1-32,126-145,398-458,581-589,774-822
Order 33-37,42-121,148-397,459-580,590-773
ProS 1-20,140-145,398-432,440-458,581-589,792-822
AlphaFold
Disorder 1-39,120-148,203-203,249-252,282-283,315-318,361-373,397-463,487-489,580-592,649-661,763-822
Order 40-119,149-202,204-248,253-281,284-314,319-360,374-396,464-486,490-579,593-648,662-762
Pfam Hmmer
PF00047 48-103 3.2e-05
PF07679 159-247 3.9e-11
PF00047 270-343 1e-07
PF07714 478-754 1.1e-160
SEG 49-60 ,124-138 ,439-453
Function
Function in SwissProt
Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation.