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IID00652
 UniprotP15498
ProteinProto-oncogene vav
GeneVAV1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
845
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 2-584 Monomer :
 Evidence X-RAY 3ky9 B Reference
       Region 3ky9 B 2-129 order
       Region 3ky9 B 130-137 disorder
       Region 3ky9 B 138-150 order
       Region 3ky9 B 151-155 disorder
       Region 3ky9 B 156-180 order
       Region 3ky9 B 181-188 disorder
       Region 3ky9 B 189-416 order
       Region 3ky9 B 417-419 disorder
       Region 3ky9 B 420-565 order
       Region 3ky9 B 566-584 disorder
 Evidence X-RAY 3ky9 A Reference
       Region 3ky9 A 2-129 order
       Region 3ky9 A 130-141 disorder
       Region 3ky9 A 142-150 order
       Region 3ky9 A 151-155 disorder
       Region 3ky9 A 156-180 order
       Region 3ky9 A 181-188 disorder
       Region 3ky9 A 189-457 order
       Region 3ky9 A 458-462 disorder
       Region 3ky9 A 463-478 order
       Region 3ky9 A 479-481 disorder
       Region 3ky9 A 482-564 order
       Region 3ky9 A 565-584 disorder
Seq 189-565 Hetero dimer : IID00312Complex
 Evidence X-RAY 3bji B Reference
       Region 3bji B 189-457 order
       Region 3bji B 458-463 disorder
       Region 3bji B 464-475 order
       Region 3bji B 476-479 disorder
       Region 3bji B 480-565 order
 Evidence X-RAY 3bji A Reference
       Region 3bji A 189-457 order
       Region 3bji A 458-462 disorder
       Region 3bji A 463-565 order
Seq 629-640,661-775 Monomer :
 Evidence NMR 2crh A Reference
       Region 2crh A 629-640 high_rmsd
       Region 2crh A 629-638 order
       Region 2crh A 661-775 order
       Region 2crh A 750-753 high_rmsd
Seq 629-641,661-775 Hetero dimer : IID00318Complex
 Evidence NMR 2ror A Reference
       Region 2ror A 629-641 high_rmsd
       Region 2ror A 629-638 order
       Region 2ror A 661-775 order
       Region 2ror A 750-753 high_rmsd
Seq 664-767 Hetero dimer : IID50282Complex
 Evidence NMR 2mc1 A Reference
       Region 2mc1 A 664-767 order
       Region 2mc1 A 700-701 high_rmsd
 Evidence NMR 2lct A Reference
       Region 2lct A 664-767 order
Seqphosphorylation
    844-844 Phosphotyrosine
    826-826 Phosphotyrosine
 
Prediction
NeProc
Disorder 138-188,560-651,770-773
Order 1-137,193-559,652-769,774-845
ProS 138-182,560-579,591-628,634-651
AlphaFold
Disorder 58-58,133-137,151-158,161-170,182-186,460-461,463-463,566-593,612-612,632-633,769-783,841-845
Order 1-57,59-132,138-150,159-160,171-181,187-459,462-462,464-565,594-611,613-631,634-768,784-840
Pfam Hmmer
PF00307 2-120 3.6e-18
PF00621 198-372 2.5e-81
PF00169 403-504 6.8e-16
PF00130 516-568 2e-15
PF07653 596-658 1.6e-05
PF00017 671-745 1.4e-23
PF00018 785-840 2.8e-24
SEG 42-51 ,356-367
Function
Function in SwissProt
Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation.