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IID00653
 UniprotP24394
ProteinInterleukin-4 receptor subunit alpha
GeneIL4R
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
825
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 26-228 Hetero trimer : P35225,P78552
 Evidence X-RAY 5e4e B Reference
       Region 5e4e B 26-48 order
       Region 5e4e B 49-49 disorder
       Region 5e4e B 50-132 order
       Region 5e4e B 133-135 disorder
       Region 5e4e B 136-165 order
       Region 5e4e B 166-168 disorder
       Region 5e4e B 169-189 order
       Region 5e4e B 190-195 disorder
       Region 5e4e B 196-221 order
       Region 5e4e B 222-228 disorder
 Evidence X-RAY 3bpo B Reference
       Region 3bpo B 27-221 order
       Region 3bpo B 222-227 disorder
Seq 26-232 Hetero dimer : P05112
 Evidence X-RAY 1iar B Reference
       Region 1iar B 26-132 order
       Region 1iar B 133-136 disorder
       Region 1iar B 137-188 order
       Region 1iar B 189-193 disorder
       Region 1iar B 194-222 order
       Region 1iar B 223-232 disorder
Seq 27-227 Hetero trimer : P05112,P78552
 Evidence X-RAY 3bpn B Reference
       Region 3bpn B 27-223 order
       Region 3bpn B 224-227 disorder
Seq 27-227 Hetero trimer : P05112,P31785
 Evidence X-RAY 3bpl B Reference
       Region 3bpl B 27-224 order
       Region 3bpl B 225-227 disorder
Seq 489-499 Hetero dimer : IID00657Complex
 Evidence NMR 1irs B Reference
       Region 1irs B 489-499 order
Seqphosphorylation
    631-631 Phosphotyrosine
    603-603 Phosphotyrosine
    575-575 Phosphotyrosine
    497-497 Phosphotyrosine
 
Prediction
NeProc
Disorder 1-27,226-259,264-272,283-712,732-825
Order 28-225,260-263,273-282,713-731
ProS 1-27,226-259,264-272,283-288,297-311,326-368,393-418,428-434,481-485,494-502,512-520,548-559,574-580,601-607,628-639,651-660,676-686,700-712,732-751,781-787,812-825
AlphaFold
Disorder 1-11,16-24,226-232,265-400,405-405,408-548,550-551,554-555,557-720,722-825
Order 12-15,25-225,233-264,401-404,406-407,549-549,552-553,556-556,721-721
SEG 362-380 ,538-551 ,607-616 ,661-682 ,786-794
Function
Function in SwissProt
Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2.
Soluble IL4R (sIL4R) inhibits IL4-mediated cell proliferation and IL5 up-regulation by T-cells.