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IID00654
 UniprotP25963
ProteinNF-kappa-B inhibitor alpha
GeneNFKBIA
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
317
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 67-302 Hetero trimer : P25799,Q04207
 Evidence X-RAY 1ikn D Reference
       Region 1ikn D 67-72 disorder
       Region 1ikn D 73-95 order
       Region 1ikn D 96-100 disorder
       Region 1ikn D 101-292 order
       Region 1ikn D 293-302 disorder
Seq 70-282 Hetero trimer : IID00207Complex,IID00710Complex
 Evidence X-RAY 1nfi E Reference
       Region 1nfi E 70-282 order
 Evidence X-RAY 1nfi F Reference
       Region 1nfi F 70-282 order
Seqphosphorylation
    36-36 Phosphoserine; by IKKA
    32-32 Phosphoserine; by IKKA and IKKE
    42-42 Phosphotyrosine; by Tyr-kinases
    283-283 Phosphoserine; by CK2
    288-288 Phosphoserine; by CK2
    291-291 Phosphothreonine; by CK2
    293-293 Phosphoserine; by CK2
    299-299 Phosphothreonine; by CK2
 
Prediction
NeProc
Disorder 1-30,281-317
Order 31-167,173-280
ProS 1-30,281-284,298-317
AlphaFold
Disorder 1-37,53-63,283-317
Order 38-52,64-282
Pfam Hmmer
PF00023 110-142 2.6e-07
PF00023 182-214 9.8e-10
PF00023 216-248 1.2e-09
SEG 282-302
Function
Function in SwissProt
Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.