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IID00656
 UniprotP29074
ProteinTyrosine-protein phosphatase non-receptor type 4
GenePTPN4
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
926
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 499-604 Hetero dimer : P03524
 Evidence X-RAY 3nfk A Reference
       Region 3nfk A 499-512 disorder
       Region 3nfk A 513-604 order
Seq 499-604 Hetero dimer : B5MDL5
 Evidence X-RAY 5ez0 D Reference
       Region 5ez0 D 499-509 disorder
       Region 5ez0 D 510-604 order
 Evidence X-RAY 5ez0 C Reference
       Region 5ez0 C 499-510 disorder
       Region 5ez0 C 511-604 order
 Evidence X-RAY 5ez0 B Reference
       Region 5ez0 B 499-509 disorder
       Region 5ez0 B 510-590 order
       Region 5ez0 B 591-593 disorder
       Region 5ez0 B 594-604 order
 Evidence X-RAY 5ez0 A Reference
       Region 5ez0 A 499-510 disorder
       Region 5ez0 A 511-590 order
       Region 5ez0 A 591-594 disorder
       Region 5ez0 A 595-604 order
Seq 499-604 Hetero dimer :
 Evidence X-RAY 5eyz B Reference
       Region 5eyz B 499-510 disorder
       Region 5eyz B 511-604 order
Seq 499-604 Hetero dimer : IID00664Complex
 Evidence X-RAY 3nfl D Reference
       Region 3nfl D 499-512 disorder
       Region 3nfl D 513-591 order
       Region 3nfl D 592-594 disorder
       Region 3nfl D 595-604 order
 Evidence X-RAY 3nfl C Reference
       Region 3nfl C 499-510 disorder
       Region 3nfl C 511-590 order
       Region 3nfl C 591-595 disorder
       Region 3nfl C 596-604 order
 Evidence X-RAY 3nfl B Reference
       Region 3nfl B 499-511 disorder
       Region 3nfl B 512-590 order
       Region 3nfl B 591-593 disorder
       Region 3nfl B 594-603 order
       Region 3nfl B 604-604 disorder
 Evidence X-RAY 3nfl A Reference
       Region 3nfl A 499-511 disorder
       Region 3nfl A 512-603 order
       Region 3nfl A 604-604 disorder
Seq 499-604 Hetero dimer :
 Evidence X-RAY 5eyz A Reference
       Region 5eyz A 499-511 disorder
       Region 5eyz A 512-604 order
Seq 499-604 Hetero dimer :
 Evidence X-RAY 5eyz D Reference
       Region 5eyz D 499-512 disorder
       Region 5eyz D 513-604 order
Seq 499-604 Hetero dimer :
 Evidence X-RAY 5eyz C Reference
       Region 5eyz C 499-511 disorder
       Region 5eyz C 512-604 order
Seq 499-604 Hetero dimer : P03524
 Evidence X-RAY 3nfk B Reference
       Region 3nfk B 499-511 disorder
       Region 3nfk B 512-591 order
       Region 3nfk B 592-593 disorder
       Region 3nfk B 594-604 order
Seq 507-612 Monomer :
 Evidence NMR 2cs5 A Reference
       Region 2cs5 A 507-612 order
       Region 2cs5 A 507-512 high_rmsd
       Region 2cs5 A 606-612 high_rmsd
 Evidence X-RAY 2vph B Reference
       Region 2vph B 513-523 order
       Region 2vph B 524-524 disorder
       Region 2vph B 525-589 order
       Region 2vph B 590-595 disorder
       Region 2vph B 596-606 order
 Evidence X-RAY 2vph A Reference
       Region 2vph A 513-606 order
Seq 513-606 Homo dimer :
 Evidence X-RAY 2vph B Reference
       Region 2vph B 513-523 order
       Region 2vph B 524-524 disorder
       Region 2vph B 525-589 order
       Region 2vph B 590-595 disorder
       Region 2vph B 596-606 order
 Evidence X-RAY 2vph A Reference
       Region 2vph A 513-606 order
Seq 611-926 Monomer :
 Evidence X-RAY 2i75 A Reference
       Region 2i75 A 611-637 disorder
       Region 2i75 A 638-701 order
       Region 2i75 A 702-702 disorder
       Region 2i75 A 703-716 order
       Region 2i75 A 717-718 disorder
       Region 2i75 A 719-913 order
       Region 2i75 A 914-926 disorder
Seqphosphorylation
    474-474 Phosphoserine
 
Prediction
NeProc
Disorder 1-26,314-512,615-633,922-926
Order 27-313,513-614,634-921
ProS 1-19,319-367,377-385,392-416,423-435,441-455,465-512,615-625
AlphaFold
Disorder 1-26,76-81,276-281,315-330,359-513,591-594,604-636,820-821,921-926
Order 27-75,82-275,282-314,331-358,514-590,595-603,637-819,822-920
Pfam Hmmer
PF00373 31-222 6e-135
PF00595 517-602 4.6e-25
PF00102 679-910 6.5e-113
Function
Function in SwissProt
Phosphatase that plays a role in immunity, learning, synaptic plasticity or cell homeostasis (PubMed:25825441, PubMed:27246854). Regulates neuronal cell homeostasis by protecting neurons against apoptosis (PubMed:20086240). Negatively regulates TLR4-induced interferon beta production by dephosphorylating adapter TICAM2 and inhibiting subsequent TRAM-TRIF interaction (PubMed:25825441). Dephosphorylates also the immunoreceptor tyrosine-based activation motifs/ITAMs of the TCR zeta subunit and thereby negatively regulates TCR-mediated signaling pathway (By similarity). May act at junctions between the membrane and the cytoskeleton.