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IID00657
 UniprotP35568
ProteinInsulin receptor substrate 1
GeneIRS1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1242
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 4-267 Homo dimer :
 Evidence X-RAY 1qqg B Reference
       Region 1qqg B 4-10 disorder
       Region 1qqg B 11-114 order
       Region 1qqg B 115-158 disorder
       Region 1qqg B 159-264 order
       Region 1qqg B 265-267 disorder
 Evidence X-RAY 1qqg A Reference
       Region 1qqg A 4-11 disorder
       Region 1qqg A 12-114 order
       Region 1qqg A 115-158 disorder
       Region 1qqg A 159-262 order
       Region 1qqg A 263-267 disorder
Seq 157-267 Hetero dimer : IID00653Complex
 Evidence NMR 1irs A Reference
       Region 1irs A 157-267 order
Seq 161-265 Hetero dimer : P06213
 Evidence X-RAY 5u1m A Reference
       Region 5u1m A 161-265 order
Seq 731-736 Hetero dimer : P06213
 Evidence X-RAY 2z8c B Reference
       Region 2z8c B 731-736 order
Seq 891-902 Hetero dimer : P08069
 Evidence X-RAY 1k3a B Reference
       Region 1k3a B 891-893 disorder
       Region 1k3a B 894-901 order
       Region 1k3a B 902-902 disorder
Seqphosphorylation
    1229-1229 Phosphotyrosine; by INSR
    1179-1179 Phosphotyrosine; by INSR
    1101-1101 Phosphoserine; by RPS6KB1 and PKC/PRKCQ
    989-989 Phosphotyrosine; by INSR
    1100-1100 Phosphoserine
    941-941 Phosphotyrosine; by INSR
    892-892 Phosphoserine
    896-896 Phosphotyrosine; by INSR
    794-794 Phosphoserine; by AMPK and SIK2
    662-662 Phosphotyrosine
    636-636 Phosphoserine; by RPS6KB1
    632-632 Phosphotyrosine; by INSR
    616-616 Phosphoserine
    629-629 Phosphoserine
    612-612 Phosphotyrosine; by INSR
    527-527 Phosphoserine; by RPS6KB1
    453-453 Phosphothreonine
    465-465 Phosphotyrosine; by INSR
    446-446 Phosphothreonine
    419-419 Phosphoserine
    348-348 Phosphoserine
    345-345 Phosphoserine
    323-323 Phosphoserine
    330-330 Phosphoserine
    312-312 Phosphoserine; by IKKB
    307-307 Phosphoserine; by RPS6KB1
    270-270 Phosphoserine; by RPS6KB1
    99-99 Phosphoserine; by CK2
    3-3 Phosphoserine
 
Prediction
NeProc
Disorder 1-9,116-146,259-1242
Order 10-56,61-115,147-258
ProS 116-123,143-146,300-303,369-375,421-440,463-467,516-520,549-555,582-591,729-735,854-870,892-902,1079-1098,1145-1150,1174-1186,1224-1242
AlphaFold
Disorder 1-9,117-158,263-1242
Order 10-116,159-262
Pfam Hmmer
PF00169 13-115 4.8e-18
PF02174 160-262 7.9e-63
SEG 119-150 ,268-281 ,383-404 ,412-424 ,505-518 ,560-574 ,666-694 ,801-815 ,829-842 ,877-882 ,1032-1043 ,1057-1068 ,1120-1135 ,1190-1227
Function
Function in SwissProt
May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity).